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We re-conceptualize the role of science policy makers, envisioning and illustrating their move from being simple investors in scientific projects to entrepreneurs who create the conditions for entrepreneurial experiments and initiate them. We argue that reframing science policy around the notion of conducting entrepreneurial experiments - experiments that increase the diversity of technical, organizational and institutional arrangements in which scientific research is conducted - can provide policy makers with a wider repertoire of effective interventions. To illustrate the power of this approach, we analyze the Human Genome Project (HGP) as a set of successful, entrepreneurial experiments in organizational and institutional innovation. While not designed as such, the HGP was an experiment in funding a science project across a variety of organizational settings, including seven public and one private (Celera) research centers. We assess the major characteristics and differences between these organizational choices, using a mix of qualitative and econometric analyses to examine their impact on scientific progress. The planning and direction of the Human Genome Project show that policy makers can use the levers of entrepreneurial experimentation to transform scientific progress, much as entrepreneurs have transformed economic progress. 相似文献
423.
Alexandre Vexliard Gordon Bishop Sinai Ucko Ingvar Werdelin Eric Hoyle Horst Magdeburg W. D. Halls Oskar Anweiler William W. Brickman R. Murray Thomas Edmund King Robert F. Lawson Anton Bemmerlein Gilbert L. de Landsheere H. H. Stern Klaus Schüttler-Janikulla Ben Morris Sherman D. Spector David A. Walker Robert J. Meeker Franklin Parker Joseph Majault Nigel Grant Rolland G. Paulston John B. Biggs Klaus Meyer 《International Review of Education/Internationale Zeitschrift für Erziehungswissenschaft/Revue internationale l'éducation》1971,17(3):343-380
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Although the validity of knowledge is critical to scientific progress, substantial concerns exist regarding the governance of knowledge production. While research errors are as relevant to the knowledge economy as defects are to the manufacturing economy, mechanisms to identify and signal “defective” or false knowledge are poorly understood. In this paper, we investigate one such institution - the system of scientific retractions. We analyze the universe of peer-reviewed scientific articles retracted from the biomedical literature between 1972-2006 and comparing with a matched control sample in order to identify the correlates, timing, and causal impact of scientific retractions. This effort provides insight into the workings of a distributed, peer-based system for the governance of validity in scientific knowledge. Our findings suggest that attention is a key predictor of retraction - retracted articles arise most frequently among highly-cited articles. The retraction system is expeditious in uncovering knowledge that is ever determined to be false (the mean time to retraction is less than two years) and democratic (retraction is not systematically affected by author prominence). Lastly, retraction causes an immediate, severe, and long-lived decline in future citations. Conditional on the obvious limitation that we cannot measure the absolute amount of false science in circulation, these results support the view that distributed governance systems can be designed to uncover false knowledge relatively swiftly and to mitigate the costs that false knowledge for future generations of producers. 相似文献
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Michael B. Adinortey Ben A. Gyan Jonathan P. Adjimani Philomena E. Nyarko Charity Sarpong Francis Y. Tsikata Alexander K. Nyarko 《Indian journal of clinical biochemistry : IJCB》2011,26(4):366-372
There is scanty information on the role of genetic factors, especially those relating to haptoglobin (Hp) phenotypes in the
expression of complications among diabetes mellitus patients in Ghana. In this study, we investigated whether there is any
association between Hp phenotypes and diabetic complications and to determine if association of the Hp phenotypes with diabetic
complications in Ghanaian diabetics differ from those in Caucasians. A total of 398 participants were randomly recruited into
the study. These comprised diabetic patients numbering 290 attending a diabetes Clinic in Ghana and 108 non-diabetic controls
from the same community. Analyses of the results indicate that most of the diabetics with complications were of the Hp 2–2
(35%) and Hp 2–1 (23.9%) phenotypes. Fewer diabetics were found to be of the Hp 2–1 M phenotype. The controls were mostly
of Hp 1–1 and Hp 2–1 M phenotypes. The odds ratio of having complications in a diabetic with an Hp 2–2 phenotype was 18.27
times greater than that for Hp 0–0. Hp 2–2 phenotype with its poor antioxidant activity may therefore be a useful predictor
for the propensity of an individual to develop diabetes complications. 相似文献
430.
David C. Murray 《资料收集管理》2018,43(1):3-27
Subject specialists seek to understand humanists' perceptions of e-books. The investigator conducted an online survey of humanities faculty at The College of New Jersey (TCNJ) to find out. The survey uncovered information about the e-book collections humanist scholars benefit from most. Respondents used and valued e-books but felt printed books were more important in their disciplines. The major disadvantages of e-books outnumbered the major advantages in scholars' estimation, but the desire for ready access to book content largely eclipsed their affinity for print and any perceived disadvantages of the e-book format. The investigator considers implications for local humanities collection development. 相似文献