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Amritanshu Prasad 《Resonance》2010,15(12):1074-1083
This is the second of a two-part article where we discuss the relation between the Gaussian binomial and multinomial coefficients
and ordinary binomial and multinomial coefficients from a combinatorial viewpoint, based on expositions by Knuth, Stanley
and Butler. 相似文献
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Ch Surendhar Reddy A. Prasad Babu B. P. Mallikarjuna Swamy K. Kaladhar N. Sarla 《Journal of Zhejiang University. Science. B》2009,10(2):133-141
Drought,flood,salinity,or a combination of these limits rice production.Several rice varieties are well known for their tolerance to specific abiotic stresses.We determined genetic relationship among 12 rice varieties including 9 tolerant to drought,flood,or salinity using inter-simple sequence repeat (ISSR) markers.Based on all markers,the nine tolerant varieties formed one cluster distinct from the cluster of three control varieties.The salt-tolerant varieties were closest to two flood-tolerant varieties,and together they were distinct from the drought-tolerant varieties.(GA)8 YG was the most informative primer,showing the highest polymorphic information content (PIC) and resolving power (Rp).The drought-,flood-,and salt-tolerant varieties grouped in three distinct clusters within the group of tolerant varieties,when (GA)8 YG was used.Sabita was the only exception.The two aus varieties,Nagina22 and FR13A,were separated and grouped with the drought-and flood-tolerant varieties,respectively,but they were together in dendrograms based on other primers.The results show that ISSR markers associated with (GA)8 YG delineated the three groups of stress-tolerant varieties from each other and can be used to identify genes/new alleles associated with the three abiotic stresses in rice germplasm. 相似文献
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Drug metabolism involves the enzymatic conversion of therapeutically important chemical species to a new molecule inside the human body. The process may result in pharmacologically active, inactive, or toxic metabolite. Drug metabolic process involves two phases, the occurrence of which may vary from compound to compound. In this article, we discuss the basics of drug metabolism, the process, metabolising organs and enzymes (especially CYP450) involved, chemistry behind metabolic reactions, importance, and consequences with several interesting and significant examples to epitomize the same. We also cover the factors influencing the process of drug metabolism, structure-toxicity relationship, enzyme induction and inhibition. 相似文献
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Two modified minimal realization methods are suggested in this paper for getting reduced order models in time domain with the help of modified Hankel matrices. The methods are computationally simple, efficient and also applicable to Multiple-Input–Multiple-Output (MIMO) systems as well. The proposed methods are validated with the help of a few examples from literature. 相似文献
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Cystic fibrosis is a common autosomal recessive disorder usually found in population of white Caucasian descent. Now it is
well documented the presence of CF disease in India with the advancement of laboratory testing. As once it was thought non
existence of this disease in our population. Most of the phenotype of CF disease was in accordance of western population.
Genetic analysis of CFTR gene in Indian CF patients revealed that most common mutation was delta F508 mutation. However, it
was less than Caucasian population. CFTR mutations are also a causative factor in the pathogenesis of male infertility due
to obstructive azoospermia. There are two most common mutation viz. IVS8-T5 and delta F508 which are responsible for congenital
absence of vas deferens in male infertility patients. Elevated levels of sweat chloride at two occasions along with the presence
of two mutations in CFTR gene was gold standard method for diagnosis of CF disease. It is noteworthy here that due to magnitude
of Indian population, the total CF disease load would be more than many European countries. Clinical data demonstrate the
prevalence of both classical and genetic form of CF in India. 相似文献
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Jyoti Aggarwal Akansha Singh Sanjeev Gupta Rajendra Prasad 《Indian journal of clinical biochemistry : IJCB》2021,36(1):120
Psoriasis is a common and an inflammatory skin disease. Trace elements play an important role in the skin metabolism such as keratinisation and melanin formation as well as immunological and inflammatory reactions. Henceforth, the present study was aimed to evaluate the essential metals with special reference to Cu and Zn. In this study, 72 psoriatic patients and 50 controls were enrolled. On the basis of PASI score psoriatic group comprising of 48 mild and 24 severe psoriatic patients were grouped. The serum trace elements analysis in the subjects revealed that serum Cu levels and Cu/Zn ratio was significantly higher in the psoriatic patients as compared to controls. Interestingly, severity of the psoriasis was well correlated with the serum Cu levels. Taking together, all these findings suggest that Cu may be a major culprit in the pathogenesis as well as in the severity of the disease. 相似文献
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Priyanka Datta Anushre Prasad Vijetha Shenoy Shrikiran Hebbar Suneel C. Mundkur Pragna Rao 《Indian journal of clinical biochemistry : IJCB》2014,29(4):520-523
The mucopolysaccharidoses (MPSs) are a heterogeneous group of rare inherited disorders caused by deficiency of lysosomal enzyme necessary to break down mucopolysaccharides or glycosaminoglycans (GAGs). We had combined clinical findings and ophthalmological features. Biochemical test for urine glycosaminoglycans was done for confirmation of diagnosis in the patient. The case of Sanfillippo’s disease was characterized by delayed development, hyperactivity with aggressive behaviour. Coarse facial feature, hirsutism and sleep disorder. Urine GAG tests for MPS was positive in the case. Based on clinical findings and biochemical tests for MPS, this case was diagnosed as a type III mucopolysaccharidoses. Urinary GAG’s electrophoresis is an important screening test for MPS suspected cases. 相似文献
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