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81.
Serap ?uhadar Mehmet K?seo?lu Yasemin ?inpolat Güler Bu?dayc? Murat Usta Tuna Semerci 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2016,26(1):53-60
Introduction
Extremely high glucose concentrations have been shown to interfere with creatinine assays especially with Jaffe method in peritoneal dialysate. Because diabetes is the fastest growing chronic disease in the world, laboratories study with varying glucose concentrations. We investigated whether different levels of glucose spiked in serum interfere with 21 routine chemistry and thyroid assays at glucose concentrations between 17-51 mmol/L.Materials and methods
Baseline (group I) serum pool with glucose concentration of 5.55 (5.44-5.61) mmol/L was prepared from patient sera. Spiking with 20% dextrose solution, sample groups were obtained with glucose concentrations: 17.09, 34.52, and 50.95 mmol/L (group II, III, IV, respectively). Total of 21 biochemistry analytes and thyroid tests were studied on Abbott c8000 and i2000sr with commercial reagents. Bias from baseline value was checked statistically and clinically.Results
Creatinine increased significantly by 8.74%, 31.66%, 55.31% at groups II, III, IV, respectively with P values of < 0.001. At the median glucose concentration of 50.95 mmol/L, calcium, albumin, chloride and FT4 biased significantly clinically (-0.85%, 1.63%, 0.65%, 7.4% with P values 0.138, 0.214, 0.004, < 0.001, respectively). Remaining assays were free of interference.Conclusion
Among the numerous biochemical parameters studied, only a few parameters are affected by dramatically increased glucose concentration. The creatinine measurements obtained in human sera with the Jaffe alkaline method at high glucose concentrations should be interpreted with caution. Other tests that were affected with extremely high glucose concentrations were calcium, albumin, chloride and FT4, hence results should be taken into consideration in patients with poor diabetic control.Key words: assay interference, glucose interference, preanalytical phase, creatinine, Jaffe kinetic assay, thyroid function tests 相似文献82.
83.
Evrikleia?Tsagala Maria?KordakiEmail author 《Education and Information Technologies》2007,12(4):281-295
This paper aims to determine the factors affecting the decisions of both male and female secondary school pupils whether or
not to pursue undergraduate studies in Computing. It is based on research conducted in Greece, on a sample of 248 pupils,
135 of whom were female. All were aged 17 and about to decide on their future undergraduate studies. Questionnaires were used,
addressing issues in the following four main categories: a) the reasons pupils chose/rejected Computing, b) how family and
friends, the media and the school environment contribute to their decision, c) how pupils perceived their future after studying
Computing and d) how pupils perceived the profile of a computer professional in terms of gender.
相似文献
Maria KordakiEmail: |
84.
85.
IPv4, the workhorse protocol of the currently popular TCP/ IP protocol suite, is fast becoming obsolete. The exponential growth
of the Internet is the main reason that has required the creation of the next generation of Internet Protocol-IPv6. IPv6 is
much more flexible and promises to take care of the address space and security issues in the foreseeable future.
Part 1 of the paper lays the foundation of the various issues involved in designing the Internet Protocol and motivates the
need for an upgraded version of this protocol. 相似文献
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87.
In many Western science systems, funding structures increasingly stimulate academic research to contribute to practical applications,
but at the same time the rise of bibliometric performance assessments have strengthened the pressure on academics to conduct
excellent basic research that can be published in scholarly literature. We analyze the interplay between these two developments
in a set of three case studies of fields of chemistry in the Netherlands. First, we describe how the conditions under which
academic chemists work have changed since 1975. Second, we investigate whether practical applications have become a source
of credibility for individual researchers. Indeed, this turns out to be the case in catalysis, where connecting with industrial
applications helps in many steps of the credibility cycle. Practical applications yield much less credibility in environmental
chemistry, where application-oriented research agendas help to acquire funding, but not to publish prestigious papers or to
earn peer recognition. In biochemistry practical applications hardly help in gaining credibility, as this field is still strongly
oriented at fundamental questions. The differences between the fields can be explained by the presence or absence of powerful
upstream end-users, who can afford to invest in academic research with promising long term benefits. 相似文献
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90.
Andreas Bauer Jan Romberg Bernhard Sch?tz 《Informatik - Forschung und Entwicklung》2005,49(3):194-205
Zur Beherrschung der komplexen vernetzten und verteilten Funktionen von Automotive-Software ist eine Beschreibung des zu erstellenden
Systems auf verschiedenen Abstraktionsebenen und schrittweise überg?nge zwischen diesen Ebenen notwendig. Neben der Definition
geeigneter Ebenen werden zur Unterstützung echtzeitkritischer Systemanteile ein einheitliches Berechnungsmodell, ebenenspezifische
Beschreibungstechniken, sowie methodische Regeln für diese Abstraktionsebenen eingeführt und in den Werkzeugprototypen AutoFocus integriert. 相似文献