Effect of Resveratrol and Nicotine on PON1 Gene Expression: In Vitro Study

Dietary and lifestyle factors have been shown to have a profound effect on paraoxonase-1 (PON1) activity. Cigarette smoke has been shown to inhibit its mass and activity where as resveratrol has been shown to enhance it. We exposed hepatoma derived cell line (HepG2) to resveratrol and nicotine in varying doses and measured PON1 enzymatic activity and PON1 gene expression. In addition, total protein content of HepG2 cells was also measured. Resveratrol in a dose of 15 μmol/l or above significantly increased the PON1 enzyme activity (p > 0.001) where as nicotine in a dose of 1 μmol/l or higher significantly reduced it (p < 0.05). The resveratrol in this dose also enhanced the PON1 gene expression whereas nicotine decreased it as compared to controls. However, the protein conent of cells was not changed suggesting that they were not cytotoxic in the doses used. Till date the antioxidant vitamins have shown disappointing results against LDL oxidation and cardiovascular protection. However, the effect of resveratrol on PON1 gene expression and activity was significant, suggesting increase in PON1 activity and enhanced gene expression may be its alternative mechanism for offering protection against cardiovascular disease and may be an potential pharmacological agent which can be used for this.     

Modifying vocational education curricula to accommodate handicapped learners: combining the efforts of special and vocational teachers

A systems approach to modifying existing vocational curricula to meet the needs of handicapped learners is presented. The roles of both special and vocational educators at each level of the modification process are discussed, together with the process as it is applied to a component of agricultural education. A significant amount of instructional technology is necessary to successfully integrate many handicapped learners into the regular vocational education environment: vocational education for handicapped persons needs to move from the stage of awareness to that of implementation.     

Managing and leveraging knowledge for organisational advantage

This paper focuses on two elements of process knowledge that we call sticky and fluid knowledge. Process knowledge, we argue, differs from the more commonly described tacit or explicit knowledge due to its domain specificity. Process knowledge is a potential source of competitive advantage for an organisation and is key to the development of intellectual capital for an organisation. Knowledge management is the operational means of delivering this intellectual capital value. From empirical research conducted, two cases are presented that illustrate process knowledge and its value and exploitation for the development of intellectual capital. The findings emphasise the necessity for a multiplicity of means for process knowledge transfer in order to ensure the widest possible distribution. In particular, in order to ensure that sticky process knowledge is transformed into fluid process knowledge, it is recommended that, communities and face2face discussions supplement knowledge exchanges via electronic networks.     

A study of thyroid status in hyperemesis gravidarum

Study was undertaken to assess thyroid status in hyperemesis gravidarum. 150 women pregnant with <20 weeks of gestation were selected randomly and out of these 100 women presenting with hyperemesis formed study group while 50 normal pregnant women served as controls. 53% of hyperemetic pregnant women were primigravidae and 82% of pregnant women presented with vomiting at less than 12 weeks of gestation. Statistically significant, 22% of hyperemetic women had increased serum T₃ levels while T₄ levels were increased in 67% of women in study group as compared to 8% and 16% respectively in control group. TSH levels were decreased in 18% of hyperemetic women as compared to 8% in control group with decrease in mean TSH level statistically significant. 22% of hyperemetic women had electrolyte disturbances and 7% were ketonuric. In clinically euthyroid women, biochemically altered thyroid function can attribute to vomiting and its prolongation to second trimester     

I still wanna be an engineer! Women,education and the engineering profession

Women's low enrolment in post-school engineering degrees continues to be a problem for engineering faculties and the profession generally. A qualitative interview-based study of Australian women engineers across the range of engineering disciplines showed the relevance of success in math and science at school to their enrolling in engineering at university. However, for a significant number of the women the positive self-image connected with school success was not maintained by their workplace experience. Using a mixed methods approach, further investigations of the attitudes and experiences of working engineers at three large firms suggest that engineering workplaces continue to be uneasy environments for professional women. Particular issues for women working as professional engineers are identified in this paper and some educational strategies are suggested in order to better prepare engineers for an inclusive and participatory professional life.     

Education as humanisation: a theoretical review on the role of dialogic pedagogy in peacebuilding education

In this literature review, we explore the potential role of education in supporting peacebuilding and societal transformation after violent conflict. Following a critical analysis of the literature published by academics and practitioners, we identify the notion of humanisation (as in the seminal works of Paulo Freire and others) as a unifying conceptual core. Peacebuilding education as humanisation is realised by critical reflection and dialogue in most curricular initiatives reviewed, an approach aimed at overcoming the contextual educational constraints often rooted in societal division and segregation, strained community relations and past traumas. We argue that education as humanisation and critical dialogue can offer pedagogical strategies and provide a compelling conceptual framework for peacebuilding education. Such a conceptual framework can serve as a basis for research in the area, especially in contexts where educational institutions tend to be structured to dehumanise.     

Research on interventions for children and young people on the autistic spectrum: a critical perspective

Developing, implementing and evaluating programmes of intervention for children and young people on the autistic spectrum are challenging endeavours. In this paper, we adopt a critical approach to research in this area, and attempt to offer an alternative perspective for understanding and interpreting empirical evaluations. We outline and discuss theoretical, methodological and practical issues and limitations associated with the current research body, and provide illustrative examples of gaps in the current literature.     

Boys: Getting it right: The ‘New’ disadvantaged or ‘disadvantage’ redefined?

Over recent years there has been widespread concern for masculinity and the education of boys in Australia. In the policy arena, this has involved a federal parliamentary inquiry into the education of boys (Boys: Getting it Right: Report on the inquiry into the education of boys, October 2002) and a federal government response to this inquiry (June 2003). This was followed by a review of the current education policy directed at gender, the Gender Equity Framework, and the development of strategies to increase the number of men going into teacher training. The way in whichGetting it Right and the federal government talk about boys and disadvantage is important. This paper argues that there is a particular understanding of disadvantage at work in this policy arena. It is an understanding of disadvantage extracted from a wider gendered power order.     

Infant educators’ beliefs about infant language development in long day care settings

This study examined infant educators’ beliefs about infant language development in the context of early childhood classrooms. Participants were 59 educators who were employed to work directly with under-two-year-old children. Educators were interviewed to determine their understandings of infant language development and Grounded Theory qualitative techniques were used to develop a conceptual model which illustrates their perceptions of the relationships between contextual, personal and teaching and learning components of their classroom contexts. The model provides a means of conceptualising ‘insider’ practitioner voices on how, as a dynamic system, contextual, individual and pedagogical components mutually interact to bring about the kinds of experiences and interactions that can shape language development. Findings have implications for understanding educators’ perspectives on infant room quality, suggesting that issues related to educator-infant ratios, staff consistency, qualifications and professional knowledge about language development processes may impact efforts to provide intentional language development support.