Effect of vitamin E supplementation on oxidative stress in hemodialysis patients

Hemodialysis represents a chronic stress status for its recipients. Many hypotheses state that this may be associated with oxidative stress. Thus, there may be deficiency of antioxidants like erythrocytic superoxide dismutase, catalase, vitamin E or increased generation of free radicals like superoxide anions. A study was carried out to investigate oxidant and antioxidant status in chronic renal failure patients undergoing hemodialysis and effect of vitamin E supplementation on these two status. Blood samples were collected from patients before and after hemodialysis and from controls. The samples were analyzed for quantitation of MDA as index of lipid peroxide, nitric oxide, vitamin E, vitamin C and enzymatic antioxidants namely erythrocyte SOD and catalase. As compared to controls, the levels of serum MDA were significantly increased and activities of erythrocyte SOD and catalase, levels of serum nitric oxide, serum vitamin E and plasma vitamin C were significantly decreased both before and after hemodialysis. The efficiency of vitamin E therapy in hemodialysis patients was assessed by re-evaluating oxidant and antioxidant status of same patients after supplementation of vitamin E. Vitamin E supplementation caused decrease in serum MDA and increase in levels of serum nitric oxide, vitamin E, vitamin C and activities of erythrocytic SOD and catalase. Our results suggest the presence of oxidative stress and the possible preventive role of vitamin E therapy in hemodialysis patients.     

Optimum calibration of a parallel kinematic manipulator using digital indicators

This paper presents a calibration method for parallel manipulators using a measurement system specially installed on an external fixed frame. The external fixed frame is important as an error reference for calibration in certain operations, such as in the configuration of a parallel manip- ulator functioning as a machine tool where the workpiece is fixed to a worktable. The pose of the end-effector is mea- sured using three digital indicators installed on the external fixed frame. To enable measurement, the end-effector is assumed to be a plane large enough that all digital indicators could touch. The error is defined as the difference between the theoretical and actual readings of the digital indicators. The geometric parameters of the parallel manipulator are optimized to minimize this error. This calibration method is low cost and feasible for compensating geometric parameter errors for a parallel manipulator. Optimal pose selection for the calibration is achieved using a swarm intelligence search algorithm. The method is implemented on a prototype of a six degrees-of-freedom （DOFs） Gough-Stewart platform constructed to function as a machine tool.     

Drugs and the Brain: Learning the impact of methamphetamine abuse on the brain through a virtual brain exhibit in the museum

Drugs and the Brain: A Serious Game, a prototype museum exhibit, was designed to employ virtual models of the brain into a video game format. It was done to create a fun and engaging way of conveying knowledge and concepts about neuroscience, as well as the impact of methamphetamine abuse on the brain. The purpose of this study is to evaluate this prototype exhibit that promises to educate participants from various age, ethnicity, and gender backgrounds, and to establish a stronger concept of drug abuse prevention among children. A quantitative methodology using the pre‐ and post‐experimental designs was conducted on 175 museum visitors. A series of two‐sample paired t‐tests and subsequent ANOVAs were performed to examine the difference between pre‐ and post‐tests and to determine if there was a difference in the results in age, gender, ethnicity, and race. Results showed that both the understanding and attitudes of the participants toward the impact of methamphetamine abuse on the brain improved significantly (p < 0.01).     

Effects of adding a preceding run-up on performance, blood lactate concentration and heart rate during maximal intermittent vertical jumping

In this study, we examined the effects of a prior run-up on intermittent maximal vertical jump performance. Seven regionally ranked male volleyball players volunteered to participate in the study. They performed three randomized tests: (1) six repeated intermittent maximal jumps (jump condition), (2) six repeated intermittent run-ups (run-up condition), and (3) six repeated run-ups followed by maximal jumps (run-up plus jump condition). All performances were assessed and blood lactate concentration and heart rate were measured before and after each of the tests. Mean ( +/- ) jump performance (64.7 +/- 2.3 cm) increased significantly (P = 0.02) over the course of the jump condition and was significantly higher (P < 0.001) than for the run-up plus jump condition (58.0 +/- 3.2 cm), which tended to decrease with repetition. Blood lactate concentration was significantly higher in the run-up plus jump condition (3.73 +/- 0.24 mmol . l(-1)) than in the jump (2.61 +/- 0.26 mmol . l(-1), P = 0.02) and run-up (2.86 +/- 0.18 mmol . l(-1), P = 0.03) conditions. The increase in heart rate was significantly higher both in the run-up plus jump condition (33 +/- 6 beats . min(-1), P = 0.05) and run-up condition (33 +/- 4 beats . min(-1), P = 0.02) than in the jump condition (21 +/- 3 beats . min(-1)). The results indicate that the addition of run-ups probably impeded performance in the repetition of vertical jumps.