图书馆学科服务知识整合情境分析

知识整合是图书馆学科服务创新活动的先决条件,然而情境因素对图书馆学科服务知识整合影响深远.在分析情境、图书馆学科服务及其知识整合相关概念基础上,构建了图书馆学科服务知识整合情境分析模型,具体探讨该模型中诸要素相互之间的作用机理,认为情境因素对图书馆学科服务知识整合能力存在显著正相关关系,而学科服务知识整合能力在情境和学科服务知识整合新绩效之间起到有效的调节作用,将为提升图书馆学科服务创新绩效理论研究与实践活动提供一个新思路、新方法.     

Quantitative detection of cells expressing BlaC using droplet-based microfluidics for use in the diagnosis of tuberculosis

This paper describes a method for the quantitative detection of cells expressing BlaC, a β-lactamase naturally expressed by Mycobacterium tuberculosis, intended for the diagnosis of tuberculosis. The method is based on the compartmentalization of bacteria in picoliter droplets at limiting dilutions such that each drop contains one or no cells. The co-encapsulation of a fluorogenic substrate probe for BlaC allows the quantification of bacteria by enumerating the number of fluorescent drops. Quantification of 10 colony forming units per milliliter is demonstrated. Furthermore, the encapsulation of single cell in drops maintains the specificity of the detection scheme even when the concentration of bacteria that do not express BlaC exceeds that expressing BlaC by one million-fold.     

Web3.O环境下高校图书馆文献检索课教学创新研究

Web3.0环境下蕴含的理念和技术改变了读者的信息行为,深刻地影响了高校图书馆读者教育培训工作,尤其是文献检索课.为此,结合Web3.0的理念和技术的内涵与特征及其对文献检索课的影响因素,构建了Web3.0环境下高校图书馆文献检索课教学创新模式,从利用3D视频再现学生学习真实情境、充分借助教育游戏服务激发学生的学习兴趣、强化泛在学习诱导学生学习的积极因素、Web3.0环境下文献检索课平台构建四方面详细地探讨了高校图书馆文献检索课教学改革的方略,以提升高校图书馆读者教育培训绩效的效果.     

省级科技文献服务平台特色资源建设调查分析

利用网络对27 个省级科技文献共享服务平台特色资源建设进行调查,结果显示：共享服务平台特色资源 平台与栏目称谓不规范、特色资源内容芜杂、获取方式参差不齐等问题。指出,可以从建立特色资源“大共享”体系、 突出区域或行业特色优势资源汇聚程度、构建以统一智慧检索平台为主的多元化获取方式等入手来提升省级科技文献 共享服务平台特色资源建设绩效,最大限度地为用户提供知识支持。     

A multiple-dose pharmacokinetics of polyethylene glycol recombinant human interleukin-6 (PEG-rhIL-6) in rats

Radiation therapy has been widely applied in cancer treatment. However, it often causes thrombocytopenia (deficiency of white blood cells) as an adverse effect. Recombinant human interleukin-6 (rhIL-6) has been found to be a very effective way against this thrombocytopenia, but IL-6 has low stability in blood, which reduces its efficacy. To increases the stability and half-life of rhIL-6, it was modified by polyethylene glycol (PEG). The pharmacokinetics and the tissue distribution of PEG-rhIL-6 labeled with ¹²⁵I were examined after subcutaneous injection in rats. The pharmacokinetic pattern of PEG-rhIL-6 was defined with linear-kinetics, and we fitted a one-compartment model with half-lives of 10.44–11.37 h (absorption, t _{1/2K a}) and 19.77–21.53 h (elimination, t _1/2Ke), and peak concentrations at 20.51–21.96 h (t _peak) in rats. Half-lives and t _peak of PEG-rhIL-6 were longer than those of rhIL-6 previously reported. In the present study, for deposition of PEG-rhIL-6 in rats, the tissue distribution examination showed that blood was the major organ involved, rather than liver. However, as to the elimination of PEG-rhIL-6, the major organ was the kidney. The excretion fraction of the injection dose recovered from urine was 23.32% at 192 h after subcutaneous administration. Less than 6% of PEG-rhIL-6 was eliminated via the feces at 192 h. These results indicate that PEG-rhIL-6 is a good candidate drug formulation for patients with cancer.     

新工科专业课程线上教学与线上考核的设计

疫情促使"新工科"专业人才培养的教学方法发生变革.如何在保证教学质量的前提下完成线上教学和线上考核,是对每位授课教师提出的挑战.本文以《焙烤食品工艺学》课程为例,设计线上理论教学和线上实践教学过程、线上考核内容和评价标准,并进行具体实施.教学实践证明,利用雨课堂合理设计教学各个环节,引导和督促学生线上学习,带动学生深入课堂,充分体现了以"学生为中心"的线上教学新模式,实现预期课程目标.     

Socioscientific Issues Thinking and Action in the Midst of Science-in-the-Making

Science & Education - Like all SSI, the COVID-19 pandemic requires decisions that are contentious, involve scientific thinking, and vary across social groups. This investigation determined how...