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排序方式: 共有46条查询结果,搜索用时 15 毫秒
31.
Ramesh Chander Kavita Singh A K Khanna S M Kaul Anju Puri Rashmi Saxena Gitika Bhatia Farhan Rizvi A K. Rastogi 《Indian journal of clinical biochemistry : IJCB》2004,19(2):141-148
Terminalia arjuna (T. arjuna) stem bark was successively extracted with petroleum ether (A), solvent ether (B), ethanol (C) and water (D). The lipid lowering
activity of these four fractions A, B, C, and D was evaluatedin vivo in two models viz., triton WR-1339 induced hyperlipemia in rats as well as fructose rich high fat diet (HFD) fed diabetic-
dyslipidemic hamsters. Hyperlipidemia induced by triton caused marked increase in the plasma levels of total cholesterol (Tc),
triglyceride (Tg) and phospholipids (PL) in rats. After treament withT. arjuna fractions A, B, C, and D at the doses of 250 mg/kg per oral (p.o.),only the ethanolic fraction (C) exerted significant lipid
lowering effect as assessed by reversal of plasma levels of Tc, Tg and PL in hyperlipidemic rats. In another experiment, feeding
with HFD produced marked dyslipidemia as observed by increased levels of plasma Tc, Tg, glucose (Glu), glycerol (Gly) and
free fatty acids (FFA) in hamsters. After treatment withT. arjuna fractions at the doses of 250 mg/kg p.o. only two fraction (B and C) could exert significant lowering in the plasma levels
of lipids and Glu. in dyslipidemic hamsters.In vitro experimentT. arjuna fractions at tested concentrations (50–500 μg/ml) inhibited the oxidative degradation of lipids in human low density lipoprotein
and rat liver microsomes induced by metal ions. These fractions when tested against generation of oxygen free radicals at
the concentrations (50–500 μg/ml), counteracted the formation of superoxide anions (O−2) and hydrodyl radicals (OH) in non enzymic test systems. The efficacy ofT. arjuna fractions as antidyslipidemic and antioxidant agents was found, fraction C> fraction B> fraction A. 相似文献
32.
Prasheeda Chandran Pradeep Garg Chandra S. Pundir 《Indian journal of clinical biochemistry : IJCB》2005,20(2):81-85
Total cholesterol, total bilirubin, calcium, oxalate, inorganic phosphate, magnesium, iron, copper, sodium and potassium were
analyzed quantitatively in gallstones, bile of gall bladder and sera of 200 patients of cholelithiasis (52 cholesterol, 76
mixed and 72 pigment stone patients) and their contents were correlated between calculi and bile and sera and bile in these
three type of stone patients. A significant positive correlation was observed between total cholesterol, total bilirubin of
calculi and bile, copper of bile and sera of cholesterol stone patients, copper of calculi and bile, total bilirubin, oxalate,
magnesium, potassium of sera and bile of pigment stone patients and oxalate and iron of stone and bile, total bilirubin, oxalate,
sodium of sera and bile of mixed stone patients. A significant negative correlation was found between magnesium of serum and
bile of cholesterol stone patients, oxalate of calculi and bile of pigment stone patients and magnesium of serum and bile
of mixed stone patients. 相似文献
33.
Bone mineral content and bone density of 234 females were measured using single photon absorptiometry technique on Computerised
Bone Density Scanner-1100. The bone mineral content and bone density showed a decreasing trend with advancing age. There was
no significant decrease in bone mineral content and bone density during pregnancy. 相似文献
34.
J. P. Prasad Y. Madhu Arushi Mandhan Payal Garg Anu Prakash Varsha Singh Daud Ali Prdeep Kumar Surinder Singh G. R. Soni Varun Singh 《Indian journal of clinical biochemistry : IJCB》2017,32(2):243-245
Current study is conducted to evaluate method verification of two locally available kits manufactured by DSI & BIORAD for quantitative estimation of Hepatitis B virus antibodies in human normal immunoglobulin by using International standard of National Institute of Biological Standards and Control. Four analyst perform five sets of test in duplicate analysing accuracy, precision, and limit of detection, sensitivity and specificity. Our results suggest that both DSI and BIORAD kits fulfil the validation criteria and are sensitive to detect up to 10 mIU concentration precisely and accurately. DSI kit is more precise at concentration 100 mIU and economically 4–5 times cheaper in local market; on the other hand, BIORAD kits provide larger detection range up to 1000 mIU. 相似文献
35.
Jayanti Mania-Pramanik B. N. Mali Rashmi S. Shah U. M. Donde 《Indian journal of clinical biochemistry : IJCB》1999,14(2):229-236
Lactoferrin, an iron-binding protein, has been proposed to act as an anti-infective agent and has been used as a diagnostic
marker in several inflammatory disorders. A sensitive enzyme-linked immunosorbent assay developed earlier was used for lactoferrin
estimation in cervical mucus. A brief study was undertaken to observe if lactoferrin is detectable in cervical mucus and to
correlate its level with reproductive tract infection, if present. One hundred and twelve cervical mucus samples were collected
from healthy as well as infected females. Some of these females were using CuT-200 intrauterine copper devices for contraception.
Women were at different phases of their menstrual cycle. The presence of detectable amount of lactoferrin in cervical mucus
was confirmed. The average level of lactoferrin in cases either with clinical symptoms of cervicitis or with proven infection
by PAP smear was significantly (t=7.6, P<0.01) higher than the normal controls. CuT users have higher (P<0.01) mean level
of lactoferrin than corresponding non-users. 相似文献
36.
Nidhi Sharma Veena Garg Arpita Paul 《Indian journal of clinical biochemistry : IJCB》2010,25(2):193-200
Alloxan administration in male Swiss albino mice, induced diabetes by increasing blood glucose concentration and reducing
hepatic glycogen content as compared to normal control group. Besides, serum lipid profile parameters such as total-cholesterol,
triglyceride, low-density lipoprotein and very low-density lipoprotein-cholesterol were also elevated, whereas, the level
of high-density lipoprotein-cholesterol was reduced significantly (P<0.05) in diabetic mice. Treatment of diabetic animals
with crude ethanolic extract of bark of Prosopis cineraria (P. cineraria) for 45 days, significantly lowered blood glucose
level, elevated hepatic glycogen content and maintained body weight and lipid-profile parameters towards near normal range.
Declined activity of antioxidant enzymes and concentration of non-enzymatic antioxidants were also normalized by drug treatment,
thereby reducing the oxidative damage in the tissues of diabetic animals and hence indicating the anti-diabetic and antioxidant
efficacy of the extract. 相似文献
37.
Fluoride content was measured in 100 urinary stones retrieved by open surgery of stone formers admitted at PGIMS Rohtak and
their respective urine and serum and compared with those of healthy individuals. The concentration of fluoride was also measured
in the sources of drinking water of these stone formers. The concentration of fluoride was definitely significantly higher
in serum (p>0.01) and highly significantly higher in urine (p>−0.001) of stone formers compared to those of healthy individuals.
The content of oxalate in serum and 24 h urine of the stone formers was also measured, which was increased significantly (p<0.005
and p<0.001) compared to healthy individuals. The concentration of fluoride was probably significantly higher in drinking
water of these stone formers than the normal ones. There was a positive correlation between the content of fluoride of urinary
stones and urine of stone patients (r=.88); stone and serum (r=.62); drinking water and stone (r=.85) and their urine and
serum (r=.54); urine and drinking water (r=.83) and serum and water (r=.51). These results indicate a definite role of fluoride
in urinary stone formation. 相似文献
38.
Arun Garg Pankaj Abrol AD Tewari Rajiv Sen Harbans Lal 《Indian journal of clinical biochemistry : IJCB》2005,20(1):85-86
Fifty children (1–4 years age) presenting with microcytic hypochromic anemia (hemoglobin less than 10g/dl) were studied in
two groups of 25 each. Group I was supplemented with iron (ferrous sulphate 6 mg/kg/d) while group II in addition to iron
was also supplemented with vitamin A (5000 IU/d). Hemoglobin concentration was found to be significantly increased after 4
weeks of iron supplementation. Rise in hemoglobin was comparatively more in-group II, as compared to group I, after 8 and
12 weeks. Serum iron was significantly higher after 4 weeks in both the groups. Packed cell volume (PCV) and retinol levels
increased significantly in-group II only. The data suggests that supplementation of vitamin A improves hematopoiesis. 相似文献
39.
A Structural Model of Educational Aspirations 总被引:3,自引:0,他引:3
The purpose of this study was to develop and test a model to predict educational aspirations of Canadian adolescents. Participants were a national sample of 4,034 students from grades 8–13 (2,037 males, 1,973 females). Results of a modified structural model included three sets of influences: a) a background factor comprised of parental occupation and education; b) a family involvement factor consisting of parental personal and school-based involvement with adolescents; and c) a personal factor with school marks, school and course perceptions, extracurricular reading and parental educational expectations as indicator measures. Educational aspirations was the main outcome variable. Results indicated that the personal factor had a strong direct influence on educational aspirations ( = 1.17, p < .001, R2 = .76). The effects of the background and family involvement factors on educational aspirations were mediated through the personal factor. Additional analyses performed in order to test the relationships obtained in the model, revealed several significant interactions amongst the three predictor factors and educational aspirations. The findings emphasize the importance of efforts to enhance the educational aspirations of adolescents through targeted change of modifiable environmental and personal factors. 相似文献
40.
Upma Garg Anju Jain Parul Singla Sarita Beri Rajiv Garg Arvind Saili 《Indian journal of clinical biochemistry : IJCB》2012,27(2):196-199
Retinopathy of prematurity (ROP) is a major cause of blindness in children. Free radicals are implicated in the development of this retinopathy. We studied the role of free radicals in ROP and enrolled 60 preterm neonates at 30–32 weeks age. Thirty neonates predisposed to development of ROP, were placed in study group and 30 normal neonates in control group. Malondialdehyde and antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPX) were measured in blood spectrophotometrically. Both the groups were followed-up to 40–42 weeks age. Serum MDA levels, erythrocyte SOD and plasma GPX were significantly high in study group at 30–32 weeks as compared to control group. At follow up visit significant increase in MDA level and decrease in SOD and GPX level among the study group was seen. This disturbance in equilibrium of oxidant and antioxidant status initiates an inflammatory process in retinal tissue leading to development of ROP. 相似文献