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81.
Aman Kumar Niti Kumari Vinny Gupta Rajendra Prasad 《Indian journal of clinical biochemistry : IJCB》2018,33(3):246-254
Renal cell carcinoma is the most common form of the kidney cancer accounting for more than 85% of the cases of which clear cell renal cell carcinoma (ccRCC) is the major histological subtype. The central molecular signature for ccRCC pathogenesis is the biallelic inactivation of VHL gene due to the presence of mutations/hyper-methylation/complete gene loss, which results in the downstream HIF activation. These events lead to increased tyrosine kinase receptor signalling pathways (RAS/MEK/ERK pathway, PI3K/AKT/mTOR pathway and NF-κB pathway), which through their downstream effector proteins causes the cell to proliferate and migrate. Recent studies have shown that VHL inactivation alone is not sufficient to induce the tumor. Mutations in numerous other genes that codes for chromatin modifiers (PBRM1, SETD2 and BAP1) and signalling proteins (PTEN and mTOR) have been identified along with activation of alternate signalling pathways like STAT and Sonic Hedgehog (SHH) pathway. It has also been shown that STAT pathway also works cooperatively with HIF to enhance the tumor progression. However, SHH pathway reactivation resulted in tumor regardless of the VHL status, indicating the complex nature of the tumor at the molecular level. Therefore, understanding the complete aetiology of ccRCC is important for future therapeutics. 相似文献
82.
83.
Wolff-Michael Roth’s In Search of Meaning and Coherence: A Life in Research, presents a selection of his previously published key works layered with current commentary and analysis. In this book review,
we explore themes that emerge through the text to trace Roth’s development as a theoretician and as a researcher. We recommend
this book for all those who are interested in Wolff-Michael Roth and the trajectory of his career, in particular those who
are just beginning their journey towards academic scholarship.
相似文献
Christina SiryEmail: |
84.
Sanjiv Gupta K. N. Singh V. Bapat V. Mishra D. K. Agarwal P. Gupta 《Indian journal of clinical biochemistry : IJCB》2008,23(1):89-91
The comparative diagnostic efficacy of two cardiac markers: CK-MB and cTn-T, has scarcely been investigated in Indian patients
of acute myocardial infarction. The present study was conducted for the same objective. The present study comprised of 59
patients. Males were 44 (75%) and females were 15 (25 %). The age of patients ranged from 32–84 years with mean age of 62.8
yrs. The mean age of males and females were 60 and 63 yrs respectively. All patients presented with history of chest pain
with a 12 leads ECG proven MI (ST Elevation, discordant T-waves). CK-MB was estimated in peripheral blood samples at 0,24,48
and 72 hours by an autoanalyzer. Following 12 hours of admission bed side Troponin-T test was done employing cTn-T marker
kit. Initially (0 hr), in 50% patients CK-MB was elevated. By end of 24 hours all the patients were CKMB positive and peak
level was attained at 24 hrs. Then it tended to decline over next 48 hrs. There were no false positive or negative results.
The cTn-T test was positive only in 22 % of ECG positive infarctions. However, the cTn-T positive cases were always accompanied
by a higher CK-MB levels. A significantly lower cTn-T positive cases in Indian patients can only be attributed to some difference
in amino acid sequence of Indian cTn-T and occidental cTn-T. A larger study from other Indian cardiac centers can either substantiate
or contradict our results. 相似文献
85.
A. P. Jain A. Mohan O. P. Gupta U. N. Jajoo S. P. Kalantri L. M. Srivastava 《Indian journal of clinical biochemistry : IJCB》1998,13(2):119-122
In view of sufficient body of evidence to substantiate the role of free radical mediated oxidative injury in myocardial infarction
(M.I.), the utility of exogenous supplementation with antioxidant substance, vitamin E was studied. Forty patients of acute
myocardial infarction were divided into two equal groups, one who received vitamin E and the other who did not. Plasma MDA
levels showed a reduction in patients of M.I. who received vitamin E as well as in those who did not, however, the decrease
was significantly more in the vitamin E treated subgroup. 相似文献
86.
Rupanwita Gupta John Fraser Christina Shane-Simpson Sharon Danoff-Burg Nezam Ardalan 《Environmental Education Research》2019,25(1):75-91
After decades of growth in environmental education (EE) in the US, the number of practitioners in the field remains unknown. A national study was conducted to estimate the field’s size through an online consumer survey panel stratified by race, ethnicity, and geographic region representing the US adult population. In addition to demographic data, three categorical questions assessed self-perceptions as environmental educators, the paid/unpaid nature of their work, and educational background in EE. Near one-fifth of the sample identified as environmental educators. Sample estimates of the overlap of environmental educators in formal education, non-formal, and unpaid (volunteer) work and their population numbers were used to calculate a conservative estimate of approximately 3.9 million environmental educators in the US Racial minority groups comprised 47% of the total number of environmental educators, indicating they were over-represented among those who consider themselves environmental educators compared to the general population. These results counter traditional assumptions that EE itself is not diverse, suggesting that inclusive practices may require more attention to who is currently excluded in organizations with low representation of minority communities. 相似文献
87.
Stavrulaki Euthemia Li Mingfei Gupta Juhi 《European Journal of Psychology of Education - EJPE》2021,36(3):693-717
European Journal of Psychology of Education - Using the perspective of self-determination theory, we examined college students’ motivation orientation as a mediator of the relationship... 相似文献
88.
Helen Chandler Yeo Susan Rickard Liow Anthea Fraser Gupta 《Asia Pacific Journal of Education》1994,14(2):1-10
Children with specific disorders of language have failed to develop normal means of spoken and written communication. International studies suggest that 5–10% of children enter school with a significant language disorder that puts them at risk educationally and also affects their social and emotional development.
The invisible nature of language disorders makes early detection and remediation difficult. In multilingual settings, such as Singapore, early detection may be particularly difficult, and remediation is complicated by the desirability of maintaining the range of languages used in the home and at school. Two case studies of specific spoken language disorder and two of written language disorder are presented to illustrate means of remediation and the importance of early intervention. 相似文献
89.
JAIN N.C. GUPTA P. 《浙江大学学报(A卷英文版)》2006,7(3):340-346
INTRODUCTION In recent years, the subject of free convection flow has attracted the attention of a number of scholars because of its possible applications to several geophysical problems. In view of these applications, a series of investigations were made to study the flow past a vertical wall. Transpiration cooling can very effectively pro-tect certain structural elements in turbojet and rocket engines, like combustion chamber walls, exhaust nozzles or gas turbine blades from hot gases. … 相似文献