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Microfluidic devices for studying heterotypic cell-cell interactions and tissue specimen cultures under controlled microenvironments 总被引:1,自引:0,他引:1
Microfluidic devices allow for precise control of the cellular and noncellular microenvironment at physiologically relevant length- and time-scales. These devices have been shown to mimic the complex in vivo microenvironment better than conventional in vitro assays, and allow real-time monitoring of homotypic or heterotypic cellular interactions. Microfluidic culture platforms enable new assay designs for culturing multiple different cell populations and∕or tissue specimens under controlled user-defined conditions. Applications include fundamental studies of cell population behaviors, high-throughput drug screening, and tissue engineering. In this review, we summarize recent developments in this field along with studies of heterotypic cell-cell interactions and tissue specimen culture in microfluidic devices from our own laboratory. 相似文献
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Recent research has revealed that a person or team wearing red is more likely to win a physical contest than a person or team wearing another color. In the present research, we examined whether red influences perceptions of relative dominance and threat in an imagined same-sex competitive context, and did so attending to the distinction between wearing red oneself and viewing red on an opponent. Results revealed a bidirectional effect: wearing red enhanced perceptions of one's relative dominance and threat, and viewing an opponent in red enhanced perceptions of the opponent's relative dominance and threat. These effects were observed across sex, and participants seemed unaware of the influence of red on their responses. Our findings lead to practical suggestions regarding the use of colored attire in sport contexts, and add to an emerging, provocative literature indicating that red has a subtle but important influence on psychological functioning. 相似文献
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Jun-qiang Xia Peng Guo Mei-rong Zhou Roger A. Falconer Zeng-hui Wang Qian Chen 《浙江大学学报(A卷英文版)》2018,19(11):864-877
Extreme floods often occur in the middle Yangtze River. The Jingjiang flood diversion zone needs to be operated during these events to protect the safety of the levees along the Jingjiang Reach. Therefore, it is important to be able to predict the potential flood risks to people and property in such an area for the purpose of flood management. In this study, an integrated numerical model for estimating the flood risks in a flood diversion zone is proposed, including a module for predicting the 2D hydrodynamic processes of flood inundation in a study area with complex topography, and a special module for estimating the flood risks to people (children and adults) and property (vehicles, buildings, and crops) using newly developed safety criteria. The proposed model was used to predict the flood inundation process and variation in hazard degrees of people and property, based on a hypothetical discharge hydrograph during the operation of the Jingjiang flood diversion zone. The model predictions show high flood loss rates for various flooded objects such as people, vehicles, buildings, and crops, with a mean loss rate for these subjects of 75% after 140 h. This suggests that the operation of a flood diversion zone should be cautiously considered, as it would likely result in a huge loss of people and property. Furthermore, an investigation was conducted into the effects of different roughness coefficients and people stability criteria on the model predictions. The results show that variable Manning’s roughness coefficients need to be used in the hydrodynamic module according to different underlying surface conditions, and a mechanics-based criterion for the stability of people in floodwaters should be adopted to assess the potential hazard degrees. 相似文献
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Hollaback! is an international movement seeking to end street harassment. Its website invites women to share narratives of their experience of street harassment as well as photos of the men who harassed them. We treat Hollaback! as an exemplar of feminist online activism and aim to identify lessons for other feminist online activists and organizations. In particular, we argue that the site’s narrative-image posts provide a powerful means of enacting countervisuality in public spaces. After analyzing 26 narrative-image postings on the Hollaback! website, we identify three collective rhetorical effects of countervisuality: Altering the traditional dichotomy of male/observer and female/observed, enacting feminist rhetorical agency through mobility in public spaces, and generating women’s solidarity through shared experience. We then argue that Hollaback!’s strategy of countervisuality insufficiently enacted the core principles of feminist rhetorical resilience, especially the concept of mêtis. We conclude by offering recommendations for feminist online activists and scholars. 相似文献