Microfluidic devices for studying heterotypic cell-cell interactions and tissue specimen cultures under controlled microenvironments

Microfluidic devices allow for precise control of the cellular and noncellular microenvironment at physiologically relevant length- and time-scales. These devices have been shown to mimic the complex in vivo microenvironment better than conventional in vitro assays, and allow real-time monitoring of homotypic or heterotypic cellular interactions. Microfluidic culture platforms enable new assay designs for culturing multiple different cell populations and∕or tissue specimens under controlled user-defined conditions. Applications include fundamental studies of cell population behaviors, high-throughput drug screening, and tissue engineering. In this review, we summarize recent developments in this field along with studies of heterotypic cell-cell interactions and tissue specimen culture in microfluidic devices from our own laboratory.     

The influence of red on perceptions of relative dominance and threat in a competitive context

Recent research has revealed that a person or team wearing red is more likely to win a physical contest than a person or team wearing another color. In the present research, we examined whether red influences perceptions of relative dominance and threat in an imagined same-sex competitive context, and did so attending to the distinction between wearing red oneself and viewing red on an opponent. Results revealed a bidirectional effect: wearing red enhanced perceptions of one's relative dominance and threat, and viewing an opponent in red enhanced perceptions of the opponent's relative dominance and threat. These effects were observed across sex, and participants seemed unaware of the influence of red on their responses. Our findings lead to practical suggestions regarding the use of colored attire in sport contexts, and add to an emerging, provocative literature indicating that red has a subtle but important influence on psychological functioning.     

Crafting Legitimate Identities: Promotional Strategies in the Ontario Non-Elite Private School Sector

Conventional wisdom within the sociology of education and organizations posits that schools achieve legitimacy by conforming to institutionalized norms and mimicking the actions of successful peers. Recent work on non-elite private schools (NEPS) shows that this institutional type may serve as an exception to this logic, generally adopting what can be perceived as illegitimate forms and practices. We conduct a mixed-methods analysis of the promotional profiles of 204 NEPS located within Ontario, Canada. We ask: How does this unorthodox organizational population carve a space for itself within a fiercely competitive and centuries-old market? Our findings illustrate that these schools engage in niche-seeking behavior, specifically catering to changing parental preferences for a caring consumer ethos with more holistic forms of child development. More broadly, they employ rhetorical strategies (e.g., fostering confidence and global-mindedness) that render their efficiency beyond the scope of verification by potential consumers. We interpret these empirical findings through the lens of contemporary theorizing within organizational sociology.     

Salivary cortisol mediates effects of poverty and parenting on executive functions in early childhood

In a predominantly low-income population-based longitudinal sample of 1,292 children followed from birth, higher level of salivary cortisol assessed at ages 7, 15, and 24 months was uniquely associated with lower executive function ability and to a lesser extent IQ at age 3 years. Measures of positive and negative aspects of parenting and household risk were also uniquely related to both executive functions and IQ. The effect of positive parenting on executive functions was partially mediated through cortisol. Typical or resting level of cortisol was increased in African American relative to White participants. In combination with positive and negative parenting and household risk, cortisol mediated effects of income-to-need, maternal education, and African American ethnicity on child cognitive ability.     

The Progression Guidance 2009–2010: a caution about the achievement targets

The article welcomes the publication of the Progression Guidance 2009–2010 as an important milestone in the government’s attempt to provide data to schools on how well children with special educational needs (SEN) are progressing. The materials hold the potential to enable school improvement partners, inspectors and educational psychologists to help schools become more accountable for the progress children with SEN make. However, they are based upon generic norms, which intentionally do not acknowledge category of need. Whilst there are strong inclusive principles underpinning this rationale, doubt is raised about their ability to help special schools set appropriate learning targets for pupils.     

Self-guided field trips for students of environments

In many learning institutions around the world, there is a trend towards larger classes, more flexible learning pathways and reduced teaching resources. Experiential learning is often used in the form of site visits or field trips for students studying engineering, natural resource management, geography and similar disciplines. Providing opportunities for students to undertake field trips without the traditional support mechanism is one of the more challenging issues for subject designers. How can large cohorts of students gain practical exposure to various aspects of the natural or built environment? Although this is typically done using traditional site visits and fieldwork with a high staff/student ratio, the goal has been to use action research to design and develop resources to enable small groups (three or four) to make self-guided visits to sites close to campus. Multimedia resources to examine and interpret aspects of the site that relate to their on-campus learning guide the students. One critical issue in the success of these activities has been proper risk assessment and control procedures. The outcome of this research is a framework to provide a safe, active learning experience by way of self-guided field trips that is suitable for implementation with large classes.     

A Qualitative Study of Juvenile Offenders,Student Engagement,and Interpersonal Relationships: Implications for Research Directions and Preventionist Approaches

Background factors that correlate with juvenile delinquency are consistent across the interdisciplinary literature base. Yet, information about the process of how risks relate to outcomes, especially within school settings, is limited. Researchers used qualitative methods to examine school and interpersonal experiences from the perspective of juvenile offenders and their families. Sixteen families were recruited from juvenile probation facilities in 2 different geographic regions. Consensual Qualitative Research methods yielded consistent themes, including the central role of advocacy to obtain appropriate school services, the importance of flexibility in discipline policies, classroom experiences that shaped outcomes, and the importance of nonjudgmental social support for the adolescents and their parents. The findings and recommendations for school consultants are presented from a preventionist standpoint, and self-determination theory is discussed in relation to future juvenile delinquency research.     

Detecting Violations of Factorial Invariance Using Data-Based Specification Searches: A Monte Carlo Study

In testing factorial invariance, researchers have often used a reference variable strategy in which the factor loading for a variable (i.e., reference variable) is fixed to 1 for identification. This commonly used method can be misleading if the chosen reference variable is actually a noninvariant item. This simulation study suggests an alternative method for testing factorial invariance and evaluates the performance of the method in specification searches based on the modification index. The results of the study showed that the proposed specification searches performed well when the number of noninvariant variables was relatively small and this performance improved as sample size increased and the size of group differences increased. When the number of noninvariant variables was relatively large, however, the method rarely succeeded in detecting the noninvariant items in the specification searches. Implications of the findings are discussed along with the limitations of the study.