Towards new molecular sensory devices: charged guest recognition by redox responsive ligand systems

This year marks the 25th anniversary of the discovery of crown ethers by C. J. Pedersen (see Mary R. Truter and C. J. Pedersen Endeavour, 30, 142, 1971). This article reviews some new developments in this important field. New crown ether and related ligand systems that contain organometallic redoxactive groups can complex and electrochemically detect cations (metals, ammonium) and anions (halide, nitrate) in polar solvents. Thus, they represent prototypes of novel molecular sensory devices of the future.     

Privacy,speech, and values: what we have no business knowing

In the United States the ascendancy of speech protection is due to an expansive and unjustified view of the value or primacy of free expression and access to information. This is perhaps understandable, given that privacy has been understood as a mere interest, whereas speech rights have been seen as more fundamental. I have argued elsewhere that the “mere interest” view of privacy is false. Privacy, properly defined, is a necessary condition for human well-being or flourishing. The opening section of this article will provide an overview of this theory. Next, after a few remarks on speech absolutism, privacy absolutism, and balancing theories, I will sketch several of the dominant argument strands that have been offered in support of presumptively weighty speech rights. While these arguments, taken together, establish that free speech is important, they do not support the view that speech should nearly always trump privacy. In final section I will present and defend a way to balance free speech and privacy claims.     

A small-gain theorem with applications to input/output systems, incremental stability, detectability, and interconnections

A general input-to-state stability (ISS)-type small-gain result is presented. It specializes to a small-gain theorem for ISS operators, and it also recovers the classical statement for ISS systems in state-space form. In addition, we highlight applications to incrementally stable systems, detectable systems, and to interconnections of stable systems.     

Patent data as a guide to industrial activity

In this paper the patenting activity of the international pharmaceutical industry in London between 1900 and 1966 is analysed. Although patent data as a measure of industrial activity is not without defects it can be used both as an adjunct to and as a surrogate for more conventional yardsticks such as concentration ratios, sales statistics and so on. The results indicate that patenting activity can be used as both an absolute and relative indicator of an industry's pace of technological change. They help pinpoint the international distribution of pharmaceutical research and development. If analysed by product or process they can aid in the understanding of why an industry's competitive behaviour is or is not primarily one of price rivalry. Finally, they illustrate the continuing role of the individual inventor.     

Probability Disassembled

While there is no universal logic of induction, the probabilitycalculus succeeds as a logic of induction in many contexts throughits use of several notions concerning inductive inference. Theyinclude Addition, through which low probabilities representdisbelief as opposed to ignorance; and Bayes property, whichcommits the calculus to a ‘refute and rescale’ dynamicsfor incorporating new evidence. These notions are independentand it is urged that they be employed selectively accordingto needs of the problem at hand. It is shown that neither isadapted to inductive inference concerning some indeterministicsystems.

1 Introduction

2 Failure of demonstrations of universality

2.1 Working backwards

2.2 The surface logic

3 Framework

3.1 The properties

3.2 Boundaries

3.2.1 Universalcomparability

3.2.2 Transitivity

3.2.3 Monotonicity

4 Addition

4.1 The property: disbelief versus ignorance

4.2Boundaries

5 Bayes property

5.1 The property

5.2 Bayes' theorem

5.3Boundaries

5.3.1 Dogmatism of the priors

5.3.2 Impossibilityof prior ignorance

5.3.3 Accommodation of virtues

6Real values

7 Sufficiency and independence

8 Illustrations

8.1 All properties retained

8.2 Bayes propertyonly retained

8.3 Induction without additivity and Bayes property

9Conclusion

     

Medicinal plants for treatment of diabetes mellitus

Many plants have been used for the treatment of diabetes mellitus in Indian system of medicine and in other ancient systems of the world. Out of these only a few have been evaluated as per modern system of medicine. From many such plants only extracts have been prepared and their usefulness evaluated in experimental diabetes in animals. In some plants likeAllium cepa, Allium sativum, Ficus bengalensis, Gymnema sylvestre, Pterocarpus marsupium etc. active hypoglycemic principles have been isolated and their mechanism of action studied. Most of them seem to act directly on pancreas (pancreatic effect) and stimulate insulin level in blood. Some have extra pancreatic effect also by acting directly on tissues like liver, muscle etc. and alter favourably the activities of the regulatory enzymes of glycolysis, gluconeogenesis and other pathways. Since the plant products have less side effects, they have the potential as good hypoglycemic drugs. They may also provide clues for the development of new and better oral drugs for diabetes.     

Leveraging global markets: Lessons from Alcoa Alumina

Globalization has contributed to the dismantling of national boundaries, which have enabled firms to compete and conduct business on a wider scale [Held, D., McGrew, A., Goldblatt, D., & Perraton, J. (1999). Global transformations. Politics, economics and culture. Cambridge: Polity Press]. Firms can move freely between different markets using Internet-based technology. While access to such markets can provide firms with greater choice of suppliers and cost efficiencies, they need to be aware of challenges that can influence their business performance. With this in mind, we examine how these factors influenced Alcoa Alumina's drive to a global procurement platform through a global marketplace. The staged adoption process experienced at Alcoa Alumina offers a learning opportunity for other firms considering the transition to global marketplace.     

Association of plasma level of thiobarbituric acid reactive substances with extent of hepatocellular injury in preterm infants with cholestatic jaundice

The present study was designed to determine the association between extent of hepatocellular injury and plasma level of thiobarbituric acid reactive substances (TBARS) in pre term infants with cholestasis. Preterm infants (<35 weeks gestation) admitted to the neonatal intensive care unit were enrolled (with their parents informed consent) in either the ‘cholestasis’ group (if their direct bilirubin was >2 mg/dl) (n=25) or in the control group (n=16). Blood samples for measurement of TBARS, direct bilirubin and transaminases were obtained with-in 24 hours of enrollment. The cholestasis and control groups were comparable with respect to gestational age, birth weight and Apgar score. Serum direct bilirubin, SGOT (EC 2.6.1.1) and SGPT (EC 2.6.1.2) levels were significantly high in the cholestasis group. Plasma levels of TBARS in cholestasis group were correlated with SGOT (F=276.92; P<0.0001) and SGPT (F=355.17; P<0.0001) and differed significantly between cholestatic and control infants. Our findings suggest that oxidative stress in preterm infants with cholestasis is associated with hepatocellular injury.     

<Emphasis Type="Italic">Enteromorpha compressa (L.) Greville</Emphasis> an edible green alga as a source of antiallergic principle (S)

Enteromorpha compressa a marine green algal species grows extensively in North coastal Andhra Pradesh. Besides its nutritional importance it has also been identified as source of anti-anaphylactic compound(s).E. compressa extracts alleviated the IgE levels raised against ovalbumin and other allergens in mice. Further,Enteromorpha extract also significantly down regulated the serum IgE levels in different murine models irrespective of their genetic background. The results obtained in this study suggest thatE. compressa extract has compound(s), which inhibit IgE immune response and may have potential in curing various types of allergies.