新时代中国特色社会主义文化自信提升过程中的问题研究

“文化自信是更基础、更广泛、更深厚的自信”,能赐予新时代中国特色社会主义事业发展更基本、更深沉、更持久的动力。本文通过阐释新时代中国特色社会主义文化自信的多维内涵,梳理坚定新时代中国特色社会主义文化自信的重要意义,探寻提升新时代中国特色社会主义文化自信过程中存在的问题,希望能为提升文化自信做出些有益探索。     

Anisotropic fluoride nanocrystals modulated by facet-specific passivation and their disordered surfaces

Rutile-type fluorides have been proven to be active components in the context of emerging antiferr-omagnetic devices. However, controlled synthesis of low-dimensional, in particular two-dimensional (2D), fluorides in a predictable and deterministic manner remains unrealized because of a lack of efficient anisotropic control, which impedes their further development in reduced dimensions. We report here that altered passivation of {110} growing facets can direct the synthesis of rutile-type fluoride nanocrystals into well-defined zero-dimensional (0D) particulates, one-dimensional (1D) rods and 2D sheets in a colloidal approach. The obtained nanocrystals show positive exchange bias and enhanced magnetic transition temperature from the coexistence of long-range antiferromagnetic order and disordered surface spins, making them strong alternatives for flexible magnetic devices and sensors.     

Understanding divergent domestication traits from the whole-genome sequencing of swamp- and river-buffalo populations

Domesticated buffaloes have been integral to rice-paddy agro-ecosystems for millennia, yet relatively little is known about the buffalo genomics. Here, we sequenced and assembled reference genomes for both swamp and river buffaloes and we re-sequenced 230 individuals (132 swamp buffaloes and 98 river buffaloes) sampled from across Asia and Europe. Beyond the many actionable insights that our study revealed about the domestication, basic physiology and breeding of buffalo, we made the striking discovery that the divergent domestication traits between swamp and river buffaloes can be explained with recent selections of genes on social behavior, digestion metabolism, strengths and milk production.     

Rapid phenotypic evolution with shallow genomic differentiation during early stages of high elevation adaptation in Eurasian Tree Sparrows

Known as the ‘third polar region’, the Qinghai-Tibet Plateau represents one of the harshest highland environments in the world and yet a number of organisms thrive there. Previous studies of birds, animals and humans have focused on well-differentiated populations in later stages of phenotypic divergence. The adaptive processes during the initial phase of highland adaptation remain poorly understood. We studied a human commensal, the Eurasian Tree Sparrow, which has followed human agriculture to the Qinghai-Tibet Plateau. Despite strong phenotypic differentiation at multiple levels, in particular in muscle-related phenotypes, highland and lowland populations show shallow genomic divergence and the colonization event occurred within the past few thousand years. In a one-month acclimation experiment investigating phenotypic plasticity, we exposed adult lowland tree sparrows to a hypoxic environment and did not observe muscle changes. Through population genetic analyses, we identified a signature of polygenic adaptation, whereby shifts in allele frequencies are spread across multiple loci, many of which are associated with muscle-related processes. Our results reveal a case of positive selection in which polygenic adaptation appears to drive rapid phenotypic evolution, shedding light on early stages of adaptive evolution to a novel environment.     

Matlab在《运筹学》教学中的应用

本文分析了高校《运筹学》教学方法中的不足,指出了在《运筹学》教学中加入Matlab语言,并且通过实例验证了利用Matlab教学比传统的教学法更有优势,在实际教学中有些具体的指导意义。     

学分制条件下实行本科生导师制的探究

本科生导师制是学分制教学管理的一个重要组成部分,是实施学分制的保证。文章阐述了学分制条件下本科生导师制的主要职责、特点和作用以及所面临的问题,提出了如何推行和完善本科生导师制的对策和建议。     

例谈高考历史学科改革类材料分析题解答方法

改革类材料分析题在高考文综试卷中一般属于选做题,并且每年基本都不缺席.因为改革类材料分析题考查的知识点不在学生日常重点复习的改革知识范围之内,所以说很多考生拿到试卷时会有无所适从之感,不知道从哪个方向回答,也不知道如何与课本知识联系.这就需要历史教师充分分析改革类材料分析题开放性、多样性等特点,并且通过带领学生研究历年...     

间歇运动激活心梗大鼠心肌NRG1-PI3K/Akt通路抑制心肌细胞凋亡

摘要：目的: 探讨心脏NRG1在间歇运动激活心梗(myocardial infarction,MI)大鼠心肌NRG1-PI3K/Akt通路抑制心肌细胞凋亡的作用。方法：雄性SD大鼠48只,随机分为假手术组(S),心梗安静组(MI),心梗+间歇运动组(ME),心梗+间歇运动+抑制剂组(MEA),每组12只。采用左冠脉前降支结扎法建立MI模型。S组手术仅穿线不结扎。ME组和MEA组在MI术后1wk进行跑台间歇运动。运动开始速度为10m/min运动10min后,速度逐渐增至25m/min×7 min,再以15 m/min×3min运动,之后依次交替进行。60min×1次/d,5d/1wk×8wk。训练结束后次日,腹腔麻醉,颈动脉插管测定LVSP、LVEDP及±dp/dtmax。之后开胸摘取心脏,进行组织学制片,Masson染色。荧光实时定量PCR测定心肌NRG1及其受体ErbB2/4表达。Western Blot法检测心肌NRG1、ErbB2/4、PI3K/Akt、Bcl-2和Bax蛋白含量。Caspase3表达及TUNEL检测观察分析心肌细胞凋亡情况。结果: MI组胶原容积百分比(CVF)和LVEDP较S组显著升高(P<0.01,P<0.01),LVSP和±dp/dtmax显著降低(P<0.01,P<0.01)。且MI后心肌ErbB4 mRNA表达显著降低(P<0.01),心肌NRG1、ErbB2和ErbB4蛋白表达显著降低(P<0.05,P<0.01,P<0.01),PI3K/Akt蛋白表达及Bcl-2/Bax比值显著降低(P<0.01,P<0.01),TUNEL阳性细胞数和Caspase3活力显著增加(P<0.01,P<0.01)。ME组CVF和LVEDP较MI组显著降低(P<0.01,P<0.01),LVSP和±dp/dtmax显著升高(P<0.01,P<0.01),心肌NRG1、ErbB2和ErbB4 mRNA及蛋白表达均显著增加(P<0.01,P<0.01,P<0.01),PI3K/Akt蛋白表达和Bcl-2/Bax比值显著增加(P<0.01,P<0.01),TUNEL阳性细胞数和Caspase3活力显著降低(P<0.01,P<0.01),且运动效应被抑制剂AG1478显著减弱。结论:间歇运动可通过激活心肌NRG1及其受体表达,上调PI3K/Akt蛋白表达,抑制心肌细胞凋亡和胶原过度增生,改善心功能。     

数字资源采购合约核心条款量化研究

本研究从数字资源采购合约的结构入手,分析当前数字资源采购中图书馆存在的偏好和盲区.进一步论述了学科包条款的成因和重要性,指出"学科包"购买实质上是数据库商的高销售额策略和图书馆追求低成本选择在利益共赢上达成的一个特定的合约结果.研究分析了11个高校图书馆数字资源采购联盟联合采购的期刊类数据库的合约结构,研究了学科包条款...     

公办学校中流动少年儿童阅读状况的调查报告

导言“一个民族的精神境界取决于公民整体阅读水平。”阅读为精神打底,为人生奠基!阅读不仅是最好的提高语文素养的方法,也是增进儿童创造力、奠定终身学习能力、提高国民人文素养的好方法。在公办学校学习的流动少年儿童的阅读现状如何?在构建和谐社会的背景下,对此做深入的调查,为有关部门更好地解决问题提供参考,无疑有积极意义。