Utility of P-SEP,sTREM-1 and suPAR as Novel Sepsis Biomarkers in SARS-CoV-2 Infection

The coronavirus disease 2019 is a highly contagious viral infection caused by SARS-CoV-2 virus, member of coronaviridae family. It causes life threatening complications due to complexity and rapid onset course of the disease. Early identification of high-risk patients who require close monitoring and aggressive treatment remains challengeable till date. Novel biomarkers which help to identify high risk patients at the early stage is high priority. Objective of this review to find utility of P-SEP, sTREM-1 and suPAR for diagnosis, risk stratification and prognosis of SARS-CoV-2 infected cases. Soluble receptors like, P-SEP, sTREM-1 and suPAR have been involved in immune regulation in SARS-CoV-2 infection and elevate more in severe cases. A comprehensive research of databases like PubMed, EMBASE, CNKI and Web of Science was performed for relevant studies. A total of nine out of fifteen research literature in initial screening were included for this review. Interestingly all studies have reported high levels of P-SEP, sTREM-1 and suPAR in SARS-CoV-2 infected cases and the biomarkers positively correlated with severity of infection. This implies that P-SEP, sTREM-1 and suPAR can be implemented as surrogate marker in blood profile for early diagnosis, risk stratification and prognosis in SARS-CoV-2 for better management in Indian population at the current situation.     

Teachers in regular classrooms: An applied setting for successful behavior programming

An operant-based program was established to study the effectiveness of regular classroom teachers as mediators for behavior change in regular classroom settings. Fifty-nine first and second graders were matched on several measures and randomly assigned to an experimental condition or a control condition. Experimental children were addressed through teacher-generatedlconsultant-supported behavior intervention strategies. Changes in behavior were examined by assessing differences from initial baseline and from first to second administration of the Child Behavior Checklist. In- class behavior change was significantly greater for the experimental condition than for the control condition, although behavior change from first to second administration of the Child Behavior Checklist was significant for all groups. A moderate to high rate of compliance to the intervention program was maintained by teachers, and moderate to high ratings of satisfaction were obtained for the program from all participants. The effectiveness, feasibility, and applicability of the program are discussed.     

How the reason for a school move relates to school adjustment

Several authors have suggested reasons for children transferring to new schools, and they have hypothesized that the reasons may affect the nature and tenure of the transition process. The present study investigated the reasons parents of 451 elementary school children gave for changing schools and demonstrated that the reasons influenced children's ability to adjust to their new schools. Specifically, children transferring because their old school closed were more competent academically and had a higher average socioeconomic status than did the other groups. On the other hand, those transferring because of changing households had poorer academic performance and more stressful life events on average than the other groups. Finally, reasons for moving not only vary according to race, but the effects of the reasons are different for each racial group. Implications for school personnel seeking to integrate transfer students into their schools effectively are discussed.     

The individual family service plan: Unresolved problems

The federal requirement to develop an Individual Family Service Plan (IFSP) for all infants and toddlers with special needs has a major conceptual difficulty that has, to date, been inadequately addressed in the literature. That problem stems from the linkage of family service to family assessment. Many authorities, attracted to parental “empowerment” theory, advocate that parents should be the authors rather than (or as well as) the objects of assessment, and that professionals and parents should be partners in assessing needs and planning services. When there is disagreement, professionals should defer to parents, who are in the best position to assess their own needs. We question the wisdom of conducting assessments with, or on, families of targeted children. But, if there are to be assessments, we argue that families are better served, and mutual respect better preserved, by a traditional complementary relationship: The professional controls the evaluation process, determines the problems (with the input of the family), and makes recommendations, which parents are then free to reject.     

Validity of the parenting inventory: Young children

The Parenting Inventory: Young Children (PI) is a rating scale that measures the developmental expectations and behaviors of parents of children who are between the ages of 1 and 4 years, 11 months. Using a representative urban sample of 1,056 mothers, the PI was found to discriminate successfully between parents with children of different ages and to have substantial item-construct correlations (content validity). The PI was not strongly related to the Adult-Adolescent Parenting Inventory, a measure of parenting attitudes (discriminant validity). Reasons for this latter finding are discussed. Potential uses of the PI for practitioners working with parents in the schools are described.