Association between 11beta-hydroxysteroid dehydrogenase type 1 gene polymorphisms and metabolic syndrome in Bosnian population

Introduction:

The enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) catalyzes the conversion of the hormonally inactive cortisone to active cortisol, thus facilitating glucocorticoid receptor activation in target tissues. Increased expression of 11β-HSD1 in adipose tissue has been associated with obesity and insulin resistance. In this study, we investigated the association of two 11β-HSD1 gene (HSD11B1) polymorphisms with the metabolic syndrome (MetS) and its characteristics in the Bosnian population.

Materials and methods:

The study included 86 participants: 43 patients diagnosed with MetS and 43 healthy controls. Subjects were genotyped for two HSD11B1 gene polymorphisms: rs846910: G>A and rs45487298: insA, by the high resolution melting curve analysis. Genotype distribution and an influence of genotypes on clinical and biochemical parameters were assessed.

Results:

There was no significant difference in the mutated allele frequencies for the two HSD11B1 gene polymorphisms between MetS patients and controls. In MetS patients, no significant associations between disease-associated traits and rs45487298: insA were found. Regarding rs846910: G>A variant, heterozygous patients (G/A) had significantly lower systolic (P = 0.017) and diastolic blood pressure (P = 0.015), lower HOMA-IR index (P = 0.011) and higher LDL-cholesterol levels (P = 0.049), compared to the wild-type homozygotes. In the control group, rs45487298: insA polymorphism was associated with lower fasting plasma insulin levels (P = 0.041), lower homeostasis model assessment insulin resistance (HOMA-IR) index (P = 0.041) and lower diastolic blood pressure (P = 0.048). Significant differences between rs846910: G>A genotypes in controls were not detected. Haplotype analysis confirmed the association of rs45487298: insA with markers of insulin resistance in the control subjects.

Conclusions:

Our results indicate that a common rs45487298: insA polymorphism in HSD11B1 gene may have a protective effect against insulin resistance.     

A Systematic Review of Life Skill Development Through Sports Programs Serving Socially Vulnerable Youth

Purpose: Despite the strong belief in sports programs as a setting in which socially vulnerable youth can develop life skills, no overview exists of life skill development in sports programs serving this youth group. Therefore, the present systematic review provides an overview of the evidence on life skill development in sports programs serving socially vulnerable youth and, insofar as it was investigated in the included studies, of the conditions conducive to life skill development in these sports programs. Method: Potentially relevant studies published during 1990 to 2014 were identified by a search in 7 electronic databases. The search combined terms relating to (a) sport, (b) youth AND socially vulnerable, and (c) life skills. Eighteen of the 2,076 unique studies met the inclusion criteria. Results: Each included study reported that at least 1 life skill improved in youth who participated in the studied sports program. Improvements in cognitive and social life skills were more frequently reported than were improvements in emotional life skills. Only a few of the included studies investigated the conditions in the studied sports programs that made these programs conducive to life skill development. Conclusions: Sports programs have the potential to make a difference in the life skill development of socially vulnerable youth. This conclusion needs to be treated with some caution, because the studies experienced many challenges in reducing the risk for bias. Several alternative research strategies are suggested for future studies in this field.     

Arabidopsis, the botanical Drosophila: from mouse cress to model organism

The small flowering plant Arabidopsis thaliana is the best-studied model organism in plant biology. More resources are allocated to research on this little weed than to the study of well-known favourites such as worms, fruit flies and mice. Yet, up to the early 1980s plant biologists had every good reason to ignore Arabidopsis: neither did it seem to possess the characteristics of a good model organism, nor did it have any agricultural promise. The sudden prestige acquired by Arabidopsis research thus constitutes a remarkable historical puzzle. What made the mouse cress into the most successful model organism to date?     

Outsourcing in higher education: the known and unknown about the practice

Outsourcing or privatising services in higher education is a common practice, but what do we really know about it? Is outsourcing effective? It is imperative that these questions be addressed since outsourcing is becoming a norm in higher education institutions. Scholars, institutional administrators and policymakers need to understand the outsourcing phenomenon and whether it is beneficial. However, there has been little research documenting the cost-effectiveness or difference in the quality of service associated with outsourcing. This study reviews 30 empirical articles to find out whether outsourcing is effective, examines the knowns and unknowns about outsourcing, and the theories often used in outsourcing in higher education. The findings show that the effect of outsourcing varies across the institution, and ranges from the positive, negative, mixed, to no effect. Over time, outsourcing may become expensive for both institutions and students because of the profit factors intrinsic within private enterprises.     

Serum macrophage migration inhibitory factor as a potential biomarker to evaluate therapeutic response in patients with allergic asthma: an exploratory study

Background: Previous studies have shown that macrophage migration inhibitory factor(MIF) is involved in the pathogenesis of asthma. This study aimed to investigate whether serum MIF reflects a therapeutic response in allergic asthma.Methods: We enrolled 30 asthmatic patients with mild-to-moderate exacerbations and 20 healthy controls, analyzing the parameter levels of serum MIF, serum total immunoglobulin E(tIgE), peripheral blood eosinophil percentage(EOS%), and fractional exhaled nitric oxide(FeNO). Lung function indices were used to identify disease severity and therapeutic response.Results: Our study showed that all measured parameters in patients were at higher levels than those of controls. After one week of treatment, most parameter levels decreased significantly except for serum tIgE. Furthermore, we found that serum MIF positively correlated with EOS% as well as FeNO, but negatively correlated with lung function indices. Receiver operator characteristic(ROC) curve analysis indicated that among the parameters, serum MIF exhibited a higher capacity to evaluate therapeutic response. The area under the curve(AUC) of MIF was 0.931, with a sensitivity of 0.967 and a specificity of 0.800.Conclusions: Our results suggested that serum MIF may serve as a potential biomarker for evaluating therapeutic response in allergic asthma with mild-to-moderate exacerbations.     

The struggle for language: perspectives and practices of urban parents with children who are deaf or hard of hearing

Research is scarce on young children with hearing impairments growing up in urban environments. A qualitative study was used to explore and describe the perspectives and practices of these children's parents. An ethnographic approach enabled documentation of parents' routines, daily activities, thoughts (perceptions), and behaviors (practices). In-depth interviews and observations were the primary data sources. Data collection occurred within a 6-month period. Research questions focused on efforts parents make independently and with others (e.g., educational staff, family members) to facilitate and support their child's efforts to communicate and acquire language. Nine parents, two grandparents, and six staff members disclosed their perspectives and practices. While similarities and differences arose, universal perspectives and practices emerged among the parents that are discussed as prevailing themes. Results suggest that the parents' struggle, systemic barriers, and the urban environment are the greatest challenges facing families. Addressing these challenges will contribute to establishment of truly equitable and effective interventions for urban children, whether deaf or hard of hearing, their parents, and other family members.     

Detection of replay attacks in cyber-physical systems using a frequency-based signature

This paper proposes a frequency-based approach for the detection of replay attacks affecting cyber-physical systems (CPS). In particular, the method employs a sinusoidal signal with a time-varying frequency (authentication signal) into the closed-loop system and checks whether the time profile of the frequency components in the output signal are compatible with the authentication signal or not. In order to carry out this target, the couplings between inputs and outputs are eliminated using a dynamic decoupling technique based on vector fitting. In this way, a signature introduced on a specific input channel will affect only the output that is selected to be associated with that input, which is a property that can be exploited to determine which channels are being affected. A bank of band-pass filters is used to generate signals whose energies can be compared to reconstruct an estimation of the time-varying frequency profile. By matching the known frequency profile with its estimation, the detector can provide the information about whether a replay attack is being carried out or not. The design of the signal generator and the detector are thoroughly discussed, and an example based on a quadruple-tank process is used to show the application and effectiveness of the proposed method.     

Optimal Nash tuning rules for robust PID controllers

In this paper, we propose tuning rules for one degree-of-freedom proportional-integral-derivative controllers, by considering important aspects such as the trade-off in the performance in the servo and regulation operation modes and the control system robustness by constraining the maximum sensitivity peak. The different conflicting objectives are dealt with by using a multi-objective optimization algorithm to generate the trade-off optimal solutions. In this context, a simple tuning rule is determined by using the Nash solutions as a multi-criteria decision making technique. The Nash criteria is shown to provide convenient trade-off solutions for the controller tuning problem. Illustrative simulation examples show the effectiveness of the method.     

Welche Rolle spielt Kompetenzdiagnostik im Rahmen von Lehr-Lernprozessen?

Competence assessment can support evidence-based teaching and learning. Depending on its specific purpose, competence assessment can be applied at the individual, the classroom or school level as well as on a national level. Large-scale-assessments are typical examples for system monitoring. Competence assessment on the individual level can provide important information with respect to individual qualification and learning outcomes. Typically, competence assessment uses psychometric models from Item-Response-Theory (IRT). However, until present, competence assessment still struggles to tap its full potential regarding feedback and individual support. Teachers often have difficulties to interpret results from competence assessments that are based on IRT. Thus, it is crucial to support teachers in using these results to improve classroom teaching. One of the main challenges of educational measurement is to align everyday classroom teaching with formative and summative assessments and to establish competence models as a common ground. Process-orientated, formative assessment can inform criterion-based feedback and, consequently, promote teaching on the basis of educational standards that were defined on the system level. However, more work needs to be done with respect to research on assessments as well as their communication and implementation into teaching practice.