The biochemical womb of schizophrenia: A review

The conclusive identification of specific etiological factors or pathogenic processes in the illness of schizophrenia has remained elusive despite great technological progress. The convergence of state-of-art scientific studies in molecular genetics, molecular neuropathophysiology, in vivo brain imaging and psychopharmacology, however, indicates that we may be coming much closer to understanding the genesis of schizophrenia. In near future, the diagnosis and assessment of schizophrenia using biochemical markers may become a “dream come true” for the medical community as well as for the general population. An understanding of the biochemistry/ visa vis pathophysiology of schizophrenia is essential to the discovery of preventive measures and therapeutic intervention.     

Preliminary studies on serum lipids, apolipoprotein-B and oxidative stress in xanthelasma

Serum lipid profile, apolipoprotein-B (apo-B), malondialdehyde levels(MDA) and superoxide dismutase (SOD) activity were assessed in 12 cases of xanthelasma with and without coronary artery disease (CAD)/hypertension (HTN) and results are compared with healthy controls. Dyslipidemia was found in 65% cases of xanthelasma as compared to 20% healthy controls. Xanthelasma patients had significantly high malondialdehyde (MDA) levels (p<0.01) and significantly decreased (p<0.05) SOD activity as compared to controls. Among xanthelasma patients, xanthelasma with CAD/HTN showed higher total cholesterol (236±32.7 vs 188±24.7 mg/dl), low density lipoprotein cholesterol (157±35.5 vs 113±16 mg/dl) and Apo-B (120.5±9.4 vs 114±19.2 mg/dl) levels as compared to xanthelasma without CAD/HTN. Results of our study indicate that xanthelasma patients with increased apo-B, MDA and decreased SOD need cardiovascular monitoring.     

Medicare Reimbursement for Counselors: Counseling Professionals’ Advocacy Beliefs and Behavior

The authors analyzed data from 5,528 American Counseling Association members to examine advocacy beliefs and behavior regarding Medicare reimbursement and advocacy for counselors. Nearly half (49.3%) of the respondents had participated in one or more forms of Medicare reimbursement advocacy. Advocacy participation differed significantly by professional status.     

Molecular Basis of Cystic Fibrosis Disease: An Indian Perspective

Cystic fibrosis is a common autosomal recessive disorder usually found in population of white Caucasian descent. Now it is well documented the presence of CF disease in India with the advancement of laboratory testing. As once it was thought non existence of this disease in our population. Most of the phenotype of CF disease was in accordance of western population. Genetic analysis of CFTR gene in Indian CF patients revealed that most common mutation was delta F508 mutation. However, it was less than Caucasian population. CFTR mutations are also a causative factor in the pathogenesis of male infertility due to obstructive azoospermia. There are two most common mutation viz. IVS8-T5 and delta F508 which are responsible for congenital absence of vas deferens in male infertility patients. Elevated levels of sweat chloride at two occasions along with the presence of two mutations in CFTR gene was gold standard method for diagnosis of CF disease. It is noteworthy here that due to magnitude of Indian population, the total CF disease load would be more than many European countries. Clinical data demonstrate the prevalence of both classical and genetic form of CF in India.     

Inherited Memories

ABSTRACT

This article explores the creation and transmission of second generation memories concerning the 1947 Partition of British India. The research is based on oral interviews with Punjabi families who migrated because of Partition and now live in Lahore and Delhi. It explores how Partition memories have been transmitted across generations within these families, and also examines similarities and differences between how the second generation interviewees from Delhi and Lahore remember Partition. It demonstrates that the second generation have not passively accepted everything that the first generation, or the state, has told them about Partition. The second generation's memories are also shaped by their age, nationality, religion and class, and the nature of contemporary politics.     

A University-Based Literacy Service-Learning Program for Youthful Offenders on Probation: A Preliminary Study of the Program’s Development,Implementation and Feasibility

This article reports on the development, implementation and feasibility of a mid-Atlantic university-community service-learning literacy program for youth on probation. Undergraduate teacher candidates served as literacy instructors for the youth. We focus on benefits and administrative challenges of developing and implementing a preliminary service-learning program for probated youth living in the community. We analyzed focus group data collected from special education undergraduate instructors, interview data collected from probated youth and their case managers, pre-post literacy assessments administered to the youth, the youths’ court files and data maintained by the community-based agency. We conclude that our model of a university-community literacy partnership has the potential to raise reading performance of youth, motivation, and promote prosocial behaviors. Addressing the educational needs of youth on probation, however, is complex and multifaceted. We find that success requires consistent communication among all stakeholders, adequate funding for leadership, organization and curricula, and ongoing assessment and evaluation.     

Using indicators as a catalyst for inclusive education in the Pacific Islands

The Pacific Island countries are committed to promoting disability-inclusive education through enactment of the Pacific Education Development Framework. To support this move, key stakeholders have identified the need for developing local and contextually appropriate indicators for measuring progress of disability-inclusive education. This paper reports on the usefulness of a newly developed tool (Pacific Indicators for Disability-Inclusive Education – Pacific-INDIE) as a catalyst in implementing inclusive education in the Pacific. Data were collected from a range of stakeholders who have used the Pacific-INDIE in three countries (Fiji, Samoa and Solomon Islands). Thematic analysis was used to identify the key themes relating to the usefulness of the tool. The key themes that emerged from the data included, positive outcomes, challenges, planned future directions, and process issues. The findings discussed are related to how the indicators can best support future policy development and implementation of disability-inclusive education across the region.