Munchausen syndrome by proxy

Munchausen syndrome by proxy is a form of child abuse in which a disorder of the child is fabricated by a parent. Although often considered rare, it may have been overlooked frequently in the past. The reported cases of children with Munchausen syndrome by proxy range in age from infancy to 8 years. Their "illnesses" consist of fabricated histories, inflicted physical findings, altered laboratory specimens, and induced disorders. The perpetrator usually is the child's mother, who may have Munchausen syndrome. Consequences of the syndrome may include painful tests, frequent hospitalizations, potentially harmful treatment, and death. The diagnosis can be made when medical and social histories are characteristic of the syndrome and clinical findings are absent, suggestive of induced illness, or resolve upon separation of the child and parent. Suspicion of the syndrome should be discussed with the family once the safety of the child is insured, and the case should be reported under the child abuse reporting law of the state. Social, family, and medical histories must be obtained and verified, and court intervention should be considered. Four patients who illustrate typical features of the syndrome are described.     

Stereotype attribution in two ethnic groups

The cross-cultural generality of previously observed stereotype attribution processes was investigated. European and Maori New Zealanders, similar in age but differing in occupational status from previous American samples, rated stimulus persons varying along three dimensions: Ethnicity (European, Maori, Samoan); Origin (Urban-Rural); and Occupation/Education (manager, skilled tradesman, laborer). Response traits were 26 adjectives found in previous research to comprise ethnic stereotypes. Factor analysis of these 26 traits showed that 5 factors were plausible in each sample, although the factor structures in the two samples were not identical. Separate between- subjects ANOV As in each sample showed that stimulus occupation accounted for most of the systematic variance in the attribution of the trait factors. This was interpreted as evidence for possible occupational stereotyping. Methodological and theoretical issues relevant to this conclusion were discussed, including the likelihood that different processes may characterize attribution in different cultures and situations.     

Measuring knowledge of natural selection: A comparison of the CINS,an open‐response instrument,and an oral interview

Growing recognition of the central importance of fostering an in‐depth understanding of natural selection has, surprisingly, failed to stimulate work on the development and rigorous evaluation of instruments that measure knowledge of it. We used three different methodological tools, the Conceptual Inventory of Natural Selection (CINS), a modified version of Bishop and Anderson's (Bishop and Anderson [1990] Journal of Research in Science Teaching 27: 415–427) open‐response test that we call the Open Response Instrument (ORI), and an oral interview derived from both instruments, to measure biology majors' understanding of and alternative conceptions about natural selection. We explored how these instruments differentially inform science educators about the knowledge and alternative conceptions their students harbor. Overall, both the CINS and ORI provided excellent replacements for the time‐consuming process of oral interviews and produced comparable measures of key concept diversity and, to a lesser extent, key concept frequency. In contrast, the ORI and CINS produced significantly different measures of both alternative conception diversity and frequency, with the ORI results completely concordant with oral interview results. Our study indicated that revisions of both the CINS and ORI are necessary because of numerous instrument items characterized by low discriminability, high and/or overlapping difficulty, and mismatches with the sample. While our results revealed that both instruments are valid and generally reliable measures of knowledge and alternative conceptions about natural selection, a test combining particular components of both instruments—a modified version of the CINS to test for key concepts, and a modified version of the ORI to assess student alternative conceptions—should be used until a more approprite instrument is developed and rigorously evaluated. © 2008 Wiley Periodicals, Inc. J Res Sci Teach 45: 1131–1160, 2008     

Inhibitory effect of Jeju endemic seaweeds on the production of pro-inflammatory mediators in mouse macrophage cell line RAW 264.7

Seaweed has been used in traditional cosmetics and as a herbal medicine in treatments for cough,boils,goiters,stomach ailments,and urinary diseases,and for reducing the incidence of tumors,ulcers,and headaches.Despite the fact that seaweeds are frequently used in the practice of human health,little is known about the role of seaweed in the context of inflammation.This study aimed to investigate the influence of Jeju endemic seaweed on a mouse macrophage cell line(RAW 264.7) under the stimulation of lipopolysaccharide(LPS).Ethyl acetate extracts obtained from 14 different kinds of Jeju seaweeds were screened for inhibitory effects on pro-inflammatory mediators.Our results revealed that extracts from five seaweeds,Laurencia okamurae,Grateloupia elliptica,Sargassum thun-bergii,Gloiopeltis furcata,and Hizikia fusiformis,were potent inhibitors of the production of pro-inflammatory mediators such as nitric oxide(NO),prostaglandin E2(PGE2),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α).Based on these results,the anti-inflammatory effects and low cell toxicity of these seaweed extracts suggest potential thera-peutic applications in the regulation of the inflammatory response.     

Improving educational assessment： A computer-adaptive multiple choice assessment using NRET as the scoring method

Assessment is central to any educational process. Number Right （NR） scoring method is a conventional scoring method for multiple choice items, where students need to pick one option as the correct answer. One point is awarded for the correct response and zero for any other responses. However, it has been heavily criticized for guessing and failure to credit partial knowledge. Despite continued research in scoring methods, conventional NR scoring method remains the most popular and widely used procedure. Thus, the problem of crediting partial knowledge and guessing still exist. In addition, the current assessment practices do not take students＇ misconceptions into consideration. Thus, there is a need to propose a new scoring method that is able to minimize guessing, credit partial knowledge, yet able to diagnose misconceptions. This study proposed the development of a Computer-Adaptive Assessment Software （CAAS） for MC items using the new Number Right Elimination Testing （NRET） which take into consideration these three elements. This paper described the rational for using the NRET, the design and development of CAAS and the results of the pilot study carried out in three secondary schools in Malaysia.     

The Design of Learning Software: Principles Learned from the Computer as Learning Partner Project

This paper describes general curriculum design principles and specific software design implementations resulting from an ongoing collaboration between software designers and programmers, researchers, and a classroom teacher and his students. Research and observations in the classroom setting led to both the emergence of useful learning principles as well as the design of a specific piece of software, E-LabBook. The paper traces the development of the software in the context of the principles that emerged during the design process.     

The rise and fall of choice in Richmond, California

The public school choice plan implemented in Richmond, California in 1987 through 1990 received much favorable publicity at the time, but in 1991 the school district filed for bankruptcy. This paper describes the choice plan and the events leading up to the financial collapse. It also presents trend data on student absenteeism, dropout rates, test scores and school desegregation. There is no evidence that the choice plan produced any improvement in these outcomes. At the same time, the district's financial failure is not necessarily attributable to the choice plan itself, but rather to the imprudent manner in which it was implemented.     

Clinical Evidence diagnosis: Developing a sensitive search strategy to retrieve diagnostic studies on deep vein thrombosis: a pragmatic approach

Objectives: To devise and evaluate a sensitive search strategy to retrieve diagnostic studies on specific diagnostic tests for deep vein thrombosis (DVT). Methods: Systematic reviews on diagnostic tests for DVT were identified and the studies cited by them used to produce a reference set of search results (to be used to evaluate different search strategies). Five existing diagnosis search filters were combined to produce a sensitive search. This combined search was then refined to produce a more specific strategy, which was run on medline and the results were checked against the reference set. This search was too specific and was modified to produce a more balanced final strategy, which was again tested and the results compared with the reference set. The sensitivity of this newly created strategy was compared with the existing diagnosis searches already found. Finally, studies identified by the final search strategy were critically appraised for validity and relevance and the selected articles were compared with those found in the reference set. Results: The final filter retrieved 124 out of 126 references from the reference set. From the search result, 227 cohort studies were selected and 147 of these were not cited in any of the systematic reviews on diagnostic tests for DVT. Conclusions: The search strategy had 98.8% sensitivity. The precision of 8.8%, although low, compares well with other strategies with high sensitivity. Most of the systematic reviews on diagnosing a DVT have omitted a number of high quality articles.