Myeloperoxidase in Chronic Kidney Disease

Numerous lines of evidence implicate a role of myeloperoxidase (MPO) in the pathogenesis of cardiovascular disease (CVD). It is a well accepted fact that patients with chronic kidney disease (CKD) are at an increased risk for CVD. MPO is a pro-oxidant enzyme which could be involved in the increased susceptibility of these patients to CVD. Hence, the levels of plasma MPO was determined in healthy controls as well as in patients with CKD [stratified with the level of their kidney failure as CKD stages II–V (end stage renal disease)]. Plasma MPO was assayed by a spectrophotometric method. Serum urea and creatinine were estimated on a clinical chemistry analyzer using standard laboratory procedures. The mean plasma MPO levels were significantly lower with advancing stages of renal failure (P < 0.001). There was a positive correlation between MPO and GFR (r = +0.89, P < 0.001) and a negative correlation with urea (r = −0.85, P < 0.001) and creatinine (r = −0.82, P < 0.001). While an inverse association was observed between plasma MPO and urea in CKD patients, such an association was not observed in control subjects (P = 0.43). In conclusion, the decline in plasma MPO levels may be due to the inhibitory effect of uraemic toxins on the enzyme.     

Burning,Fluttering, and Extinguishing of a Candle Flame in a Tube

In this article, we report some experimental results on the behaviour of the flame of a candle kept at the bottom of a glass tube, which is open at the top and closed at the bottom. Thus, the supply of oxygen for the continuous burning of the flame is possible only from the top open end of the tube. We find that the candle burns steadily below a critical tube height. Above this height, the flame oscillates in size, and a further increase in tube height leads to the flame extinguishing quickly.     

A Multilevel Analysis of Asian Immigrant Children’s Reading Achievement in the Early Years: Evidence from the ECLS-K Data

This study investigates 1.5 generation¹ Asian immigrant children’s (n = 264) early literacy achievement patterns, treating them as a heterogeneous group. Specifically, the within-group variances in reading achievement from kindergarten to third grade are examined, drawing on four waves of data from the ECLS-K class of 1998–1999. Our analysis shows that ethnicity plays a role in shaping the children’s initial reading readiness and later growth, but the effects of languages spoken at home are not significant. Our analysis also demonstrates a persistent achievement gap between low- and high-socioeconomic status (SES) Asian groups. However, gender difference in terms of children’s reading development is not found to be significant. There is also no interaction between SES and the other factors such as gender, ethnicity and language backgrounds.