Electronic detection of dielectrophoretic forces exerted on particles flowing over interdigitated electrodes

Dielectric particles flowing through a microfluidic channel over a set of coplanar electrodes can be simultaneously capacitively detected and dielectrophoretically (DEP) actuated when the high (1.45 GHz) and low (100 kHz–20 MHz) frequency electromagnetic fields are concurrently applied through the same set of electrodes. Assuming a simple model in which the only forces acting upon the particles are apparent gravity, hydrodynamic lift, DEP force, and fluid drag, actuated particle trajectories can be obtained as numerical solutions of the equations of motion. Numerically calculated changes of particle elevations resulting from the actuation simulated in this way agree with the corresponding elevation changes estimated from the electronic signatures generated by the experimentally actuated particles. This verifies the model and confirms the correlation between the DEP force and the electronic signature profile. It follows that the electronic signatures can be used to quantify the actuation that the dielectric particle experiences as it traverses the electrode region. Using this principle, particles with different dielectric properties can be effectively identified based exclusively on their signature profile. This approach was used to differentiate viable from non-viable yeast cells (Saccharomyces cerevisiae).     

Designed by the pupils,for the pupils: an autism‐friendly school

There is growing interest in promoting autism‐friendly environments, especially in a school setting. Findings to date have generally advocated an accepted reductionist or generalist approach when providing an autism‐friendly built environment. However, previous studies, while very well intentioned, have rarely involved those with autism spectrum condition (ASC) to comment on and then instruct designers on what, for them, constitutes an autism‐friendly learning environment. If going to be truly inclusive, the authors contend that those who are most knowledgeable about ASC, those with ASC, should, whenever possible, be given the opportunity to comment on the design of our shared built environment. Hence this article first introduces some of the challenges faced by those with ASC in trying to cope with their surroundings, before proceeding to outline the development of a simple school design ‘jigsaw’ kit that helped pupils with ASC to communicate ideas for their perfect school. Used in four design workshops, secondary school aged pupils (aged 13 to 18) with ASC imparted their likes, dislikes and what was most important to them within the school environment. This facilitated comparison with current autism‐friendly guidelines and provides a valuable insight into the mind of the secondary pupil with ASC. It is hoped that by increasing awareness and then including those with ASC in describing what might constitute an autism‐friendly learning environment, it will help facilitate greater inclusion of the child with ASC into mainstream education and society at large.     

Teaching Statistics – Despite Its Applications

Evidence‐based policy requires sophisticated modelling and reasoning about complex social data. The current UK statistics curricula do not equip tomorrow's citizens to understand such reasoning. We advocate radical curriculum reform, designed to require students to reason from complex data.     

Cytokine responses to resistance training in people with multiple sclerosis

Exercise for individuals with multiple sclerosis (MS) has been shown to improve cardiovascular function, increase strength and endurance, and reduce fatigue. The impact of exercise on immune function in the disease, however, remains mostly unexplored. Ten female MS patients participated in an 8 week programme of twice-weekly progressive resistance training, with pre- and post-training assessment of serum concentrations of cytokines IL-2, IL-4, IL-6, IL-10, CRP, TNF-alpha and IFN-gamma. After training, IL-4, IL-10, CRP and IFN-gamma showed statistically reduced resting concentrations in blood, while TNF-alpha showed non-significant reductions and IL-2 and IL-6 remained unchanged. These results suggest that progressive resistance training may have an impact on cytokine concentrations in individuals with MS and should be confirmed in studies with stronger statistical power. The impact of these changes on overall immune function in MS and on disease status and prognosis remains to be determined.     

Influence of starting position on finishing position in World Cup 500 m short track speed skating

Top short track speed skaters and their coaches have suspected that starting positions influence finishing positions, especially in the 500 m racing distance. The objective of this study was to examine systematically the influence of starting position on finishing position in 500 m short track speed skating. The data analysed included results from World Cup 500 m races ranging from the 1999-2000 season through to the end of the 2003-2004 season. All 500 m men's and women's races with four skaters starting and finishing (preliminaries, heats, quarter-finals, semi-finals and finals) were included in the data set. The association between starting position and finishing position was examined using Kendall's tau. Results show that for both sexes, there is a significant positive correlation between starting position and finishing position (P<0.001). This effect is generally more pronounced in semi-finals and finals than it is in preliminaries, heats and quarter-finals. Strategies to counter this inequity are proposed, drawing upon similar experiences in other sports.     

Developing tests of impaired coordination for Paralympic classification: normative values and test–retest reliability

Current methods of assessing coordination in Paralympic classification are non-instrumented and are based on ordinal scales of measurement and therefore impede the development of evidence-based methods of classification. This paper describes an instrumented battery of tests that measure impaired coordination in a way that will permit evidence-based classification. Test–retest reliability and normative values for each of the tests are reported. Twenty participants visited the laboratory on two occasions, each time completing 11 tests: three running-specific, lower-limb reciprocal tapping tests (yielding five outcome measures); four throwing-specific, upper-limb discrete tapping tests (yielding four outcome measures); and four wheelchair-specific, upper-limb reciprocal tapping tests yielding seven outcome measures. Reliability was evaluated using Intra-class Correlation Coefficients (ICCs), Standard Error of Measurement, Limits of Agreement and Paired t-tests. ICCs for fourteen of the 16 outcome measures were excellent (ICC ≥ 0.80), although systematic bias was evident in two of these—a unilateral, running-specific lower-limb tests on the non-dominant side, and a unilateral wheelchair-specific upper limb test on the dominant side. ICCs for two tests—a bilateral wheelchair-specific upper limb test (0.74), and a unilateral wheelchair-specific upper limb test on the non-dominant side (0.54)—were good and fair respectively. Results indicate that 12 of the measures evaluated have measurement properties that will facilitate the development of evidence-based methods of Paralympic classification in athletics. Positional adjustment and increased familiarization may improve reliability in the other four. Studies evaluating reliability of this test battery in people with coordination impairments are warranted.     

Maturity-associated variation in sport-specific skills of youth soccer players aged 13-15 years

The aim of this study was to estimate the contribution of experience, body size and maturity status to variation in sport-specific skills of adolescent soccer players. The participants were 69 players aged 13.2-15.1 years from three clubs that competed in the highest division for their age group. Height and body mass were measured and stage of pubic hair development was assessed at clinical examination. Years of experience in football was obtained at interview. Six football skill tests were administered: ball control with the body, ball control with the head, dribbling with a pass, dribbling speed, shooting accuracy and passing accuracy. Multiple linear regression analysis was used to estimate the relative contributions of age, stage of sexual maturity, height, body mass and years of formal training in soccer to the six skill tests. Age, experience, body size and stage of puberty contributed significantly but in different combinations to the variance in four of the six skill tests: dribbling with a pass (21%; age, stage of maturity), ball control with the head (14%; stage of maturity, height, body height x body mass interaction), ball control with the body (13%; stage of maturity, years of training) and shooting accuracy (8%; stage of maturity, height; borderline significance, P = 0.06). There were no significant predictors for the tests of dribbling speed and passing accuracy. In conclusion, age, experience, body size and stage of puberty contributed relatively little to variation in performance in four of the six soccer-specific skill tests in adolescent footballers aged 13-15 years.