Sickle Cell Trait Presenting as Chronic Calcific Pancreatitis with Pseudocyst- A Case Report

Sickle cell disease is known to cause acute pancreatitis either due to gall stones obstructing the pancreatic duct or by vaso-occlusive mechanism. However chronic pancreatitis is a very rare complication in sickle cell anemia. We report a case of sickle cell trait presenting with chronic pancreatitis with pseudo cyst. USG abdomen and CT abdomen confirmed the diagnosis of chronic calcific pancreatitis with pseudocyst. Etiological work up for other causes did not reveal anything except sickle cell trait. This case represents a rare association between chronic calcific pancreatitis and sickle cell trait.     

Combined Analysis of Anti SARS-CoV-2 IgG and IgM Responses in COVID19 Patients in India

Coronavirus disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a global health problem, India being the second most affected country. The kinetics of antibody response to SARS-CoV-2 in Indian population is not studied yet. To understand serological response in relation to age, gender, time period and severity of disease, Roche Elecsys anti-SARS-CoV-2 test was used which analysed both IgM and IgG. One hundred and three COVID-19 patients were enrolled. Seropositivity was seen in 64% of patients, with 33% at ≤ 7 days, 62% between 8 and 15 days and 81% at ≥ 16 days from the time of admission. Men (65%) showed higher antibody response than women (59%), whereas no difference was observed in seropositivity with respect to age of the patients. Dynamics of antibody responses revealed individual variations. Patients in ICU had higher antibody reactivity with 67% positivity as compared to 60% positivity in non-ICU patients. Kinetics of antibody response during COVID-19 disease varied in relation to gender, age, time period and severity and these factors might play an important role in treatment and control of COVID-19.     

An easy, rapid and cost-effective method of microtitration

An economical and less time consuming microtitration method is presented. The method has been applied to two types of titration, viz., neutralization and complexometric. The results obtained by the new method are comparable to those obtained by conventional method using burette and pipette. It is proposed that this method can be implemented in high school and undergraduate classes as the quantities of chemicals consumed are far less and the experiment can be completed within the given laboratory period.     

Space allocation to academic departments in a high rise building of an Australian educational institution

This study examines an important aspect of the college space planning problem for an institution which has a high density development on the campus site. A model is developed which minimizes the vertical student pedestrian movements within the building. The optimal solution obtained from the model was adjusted marginally to alleviate space dispersal problems which tend to militate against departmental coordination and interaction. The resulting assignment of space was found to be better than the existing deployment of teaching department accommodation from the perspective of minimization of student pedestrian traffic and intradepartmental interaction and administration. The study is concluded by suggesting that future investigators should consider a multiobjective approach to the resolution of space allocation problems. It indicates that academic interaction should be maximized whilst costs of relocation of occupants from existing building floors should be minimized. The consideration of these goals, together with the objectives examined in this study, appear to be central to the solution of the college space allocation problem.     

Evaluation of polymerase chain reaction for rapid diagnosis of clinically suspected tuberculous pleurisy

Pleural effusion is one of the commonest presentations of tuberculosis, the clinical manifestations being typically abrupt resembling bacterial pneumonia. Since delayed hypersensitivity is the underlying immune response, bacterial load is very low. Owing to these facts, tuberculous pleurisy as an extra-pulmonary disease poses a diagnostic dilemma. The conventional bacteriological methods rarely detect Mycobacterium tuberculosis in pleural fluid and are of limited use in diagnosis of tuberculous pleurisy. We evaluated the efficacy of polymerase chain reaction (PCR) in the diagnosis of tuberculous pleurisy by targeting the gene segment coding for MPB64 protein specific forMycobacterium tuberculosis. Based on the clinical criteria, 82 patients with lymphocytic exudative pleural effusion were included in the study. Patients were analyzed in two groups; one group consisting of 48 patients of tubercular pleural effusion confimed by various diagnostic procedures and another group of 34 patients comprising of non-tubercular pleural effusion. There were no false positive results by PCR and the specificity worked out to be 100%. Twenty two patients tested positive for Mantoux with a sensitivity of 45%. ZN-staining for AFB was found in samples from 15 patients (20% sensitivity). ADA was positive for 28 patients with a sensitivity of 53%. PCR was positive for 32/48 patients (67% sensitivity). Thus, PCR was found to be more sensitive than any other conventional method in diagnosis of clinically suspected tubercular pleurisy.     

A methodological framework for understanding and describing discipline‐based scholarship of teaching in higher education through design‐based research

Since their inception in 1993 at an Australian university, the workshop tutorials in physics have evolved and grown beyond the initiating department. In this paper, we adopt an interpretive perspective to: (i) reflect on why the tutorials continue to be successful; (ii) use models from literature to understand that success; and (iii) abstract key features that can inform scholarly inquiry into teaching and learning in higher education in other contexts and discipline areas. Practitioner (action) research and design‐based research not only provide useful methodological frameworks that support the success of the workshop tutorials, but they also offer a worthwhile methodological strategy for fostering scholarly inquiry into university teaching and student learning.     

Students' Understandings of Gravity in an Orbiting Space-Ship

We report on an investigation of students' ideas about gravity after a semester of instruction in physics at university. There are two aspects to the study which was concerned with students' answers to a carefully designed qualitative examination question on gravity. The first aspect is a classification of the answers and a comparative study of the ways the problem was tackled by two large groups of students who had different backgrounds in physics and were exposed to different teaching styles. The second aspect is to investigate how students link concepts to solve the problem. We used a phenomenographic analysis of student responses to extract patterns of reasoning and alternative conceptions behind the solutions. We found no differences between the classes of answers given by students in the two courses. Our analysis also identifies a hierarchy in the complexity of the hypothetical reasoning pathways, which we interpret as reflecting the ways in which students may link concepts and resolve conflicts as they solve the problem. The hypothetical reasoning pathways may help educators to develop instructional material or lecture room dialogue in order to tease out key issues. An unexpected finding is that there is a discrepancy between our conclusion that the two groups of answers are similar and the distribution of marks awarded by the examiner – which implies that the quality of the answers is different for the two groups.