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Suparna Dhara Anindya Dasgupta Jayanta Kumar Rout Ushasi Banerjee Sayantan Dasgupta Arindam Ghosh 《Indian journal of clinical biochemistry : IJCB》2015,30(1):99-103
Psoriasis is a chronic inflammatory disease associated with an increased insulin resistance, obesity and cardiovascular risk. The present study was aimed to assess insulin resistance and pattern of body fat deposition in psoriasis. Body mass index (BMI) and waist circumference (WC) were measured in 40 psoriatic patients and 46 age- and sex-matched control subjects. Fasting blood glucose (FBG) and serum insulin level were measured by standard photometric method and ELISA respectively. HOMA-IR (homeostatic model of insulin resistance) was calculated by appropriate software. The results indicated that case and control groups were comparable in terms of age and sex (p = 0.934) with an increased prevalence of psoriasis among male subjects (60 %). FBG and mean WC between the two groups were statistically not significant (p value = 0.271 and 0.21 respectively). BMI was significantly higher in case group compared to the control group (p = 0.049). Serum insulin level and insulin resistance in the psoriatic patients were significantly higher (p value <0.001). Multiple regression analysis revealed that insulin resistance (measured by HOMA) was dependent on BMI and WC at a significance level of p < 0.001 and 0.043 respectively. Therefore, the psoriatic patients in this region have significantly high amount of fasting serum insulin level along with an increased IR though their FBG level remains normal. Furthermore, these abnormalities are significantly dependent on total body fat as well as abdominal fat deposits. We suggest that psoriatic patients need to be evaluated for metabolic syndrome and managed accordingly. 相似文献
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Krishan Kumar. 《Higher Education Quarterly》1976,30(4):381-382
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P.K. Kapur Hoang Pham Vijay Kumar Adarsh Anand 《The Journal of High Technology Management Research》2012,23(2):122-129
In this paper, a decision model is presented for the sales of software product to determine the profit and marketing policy under the influence of promotional efforts. The paper focuses on dependence of the optimal profit on the promotional efforts when there is diffusion effect of demand on the sales function. An elaborate optimization policy considering the dynamic nature of production cost function is proposed and numerical example is illustrated. The paper also studies the behavior of the future profit and its impact on profit maximization model by considering the constant price during the entire planning horizon. The experimental results greatly help us to identify the contributions of each selected parameter and its weight. Some conclusions, limitations of this study and future direction are also discussed. 相似文献
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Ipsita Choudhury R. Jothimalar Arun Kumar Patra 《Indian journal of clinical biochemistry : IJCB》2012,27(3):265-269
Hypertension, a well known risk factor for various cardiovascular, peripheral vascular and renal events is an important public health challenge. Renin angiotensin system (RAS) being the most vital pathogenic mechanism of hypertension is mediated by a key component; the angiotensin converting enzyme (ACE). The present study was aimed to know the relationship of ACE gene polymorphism and the possible risk of development of hypertension in south Indian population. The study included 101 clinically diagnosed hypertensive patients without any associated disease condition and 81 age and sex matched apparently healthy controls. Genotyping was performed using a polymerase chain reaction, (PCR) amplification of the intron 16 fragment harboring the 287 bp Alu repeat sequence. Three possible genotypes D/D, I/I homozygous and I/D heterozygous were analyzed where the D/D genotypes corresponds to higher ACE levels (D-Deletion, I-Insertion). The PCR products were separated on 2 % agarose gel. Statistical analysis was performed using SPSS.15 software program. We found a significance in frequency of D/D genotype in the hypertensive patients compared to the control group (p = 0.0005, odd’s ratio = 4.157). This suggested that ACE (D/D) genotypes are more prone for the development of hypertension. This is relatively a pilot study; but nevertheless may assist in identifying the pathophysiological cause of hypertension. 相似文献
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Tapas Kumar Ghosh K.C. Panda 《Library Collections, Acquisitions, and Technical Services》2010,34(2-3):45-50
The vital task of the libraries attached to the educational institutions of higher learning is the collection development of information resources as per the requirements of the users. The Central Library of IITs have long been recognized their responsibility to support the study and research of their parent institutions with the rich collection development of information resources both in print as well as electronic format to cater the needs of the academic communities as per the multi-disciplinary and diverse academic program of the respective institutions where greater emphasis on collection of serials, the essential and integral component of updated scholarly communication. The study provides a vivid picture about the current status of serials collection in the libraries attached to the Premier Institutions of India in the field of science and technology to boost up the academic performances. 相似文献
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