Oxidative stress in cases of chronic fluoride intoxication

This study was conducted to find out the level of oxidative stress and effect of supplementation of vitamin C, D and Calcium on levels of SOD, serum and urinary fluoride in children residing in endemic fluorosis area. For this the fluoride belt of Jaipur district was selected. The parameters selected were Super oxide dismutase, serum fluoride and urinary fluoride. The study was conducted on one hundred children, selected from four areas (25 from each area) consuming water containing 1.2, 2.4, 5.6 and 13.6 mg/l of fluoride. Drinking water fluoride, serum and urinary fluoride were measured by Ion selective electrode method. Serum SOD by Xanthine oxidase method using kit of Ransod (kit cat. No. SD125). The post treatment values showed a significant reduction in serum fluoride and SOD. Urinary fluoride levels increased significantly in post treatment stage. The results revealed a normal SOD levels in all groups but an increasing trend was observed with increasing fluoride concentration. Treatment with Calcium, Vitamin D and Vitamin C showed a significant reduction in serum fluoride and SOD and increase in urinary fluoride. A high positive correlation between pretreatment and post treatment group was observed in serum fluoride, SOD and urinary fluoride (P < 0.05). The study indicated an increasing oxidative stress in cases of fluorosis with increasing drinking water fluoride concentration. Treatment with Calcium, Vitamin D and Vitamin C resulted a significant reduction in serum fluoride and SOD and increase in urinary fluoride.     

Memory training program for older adults

ABSTRACT

Objective: Memory loss affects a large proportion of older adults. Research indicates a positive association between memory training and better memory performance as people age. However, studies on specific memory training using an experimental design are limited. This study explored whether memory training has improved memory performance in a group of older adults.

Method: A convenience sample of 48 participants was recruited from two communities. Disregarding dropouts, this left 23 experimental (mean age = 65.4 ± 6.0, range = 56–80) and 19 control participants (mean age = 64.5 ± 4.9, range: 57–72). The intervention consisted of 60-min classes held on a weekly basis continuing for 8 weeks. The class session was held after a 1-h exercise class and before a 1-h session of cognitive games. The pre–post objective memory performances, including associative, list, text, place, grocery learning, and transfer-effect of daily event memory (ecology validity), were examined to determine whether the intervention was effective.

Results: Intragroup: With Wilcoxon test, the findings showed that the intervention of both the list and place learning had significant differences for the experimental group, but not for the control group. Intergroup: The main effects were found for the associative and text learning. The mixed design ANOVA indicated that there is an interaction (time x group) on the dependent variable of the place learning test. Daily events memory: We found within group that the pre–post differences were significant for the experimental group but not for the control group.

Conclusion: The study showed that memory training can help older adults to ameliorate memory loss problems and these findings deserve more attention.     

Emerging themes in Finnish archival science and records management education

The paper focuses on the convergence of Finnish research and education in archival science with information science in general and in records management with information management in particular. Two issues influencing this development are: the convergence of professionals previously worked in the archival and library sectors and in information management and services; and the wide-spread, extensive growth in the use of digital technology to manage internal and external organizational information. At the level of society the opportunities provided by digital technology to manage heritage information in memory organizations like archives, libraries and museums, are tremendous and the role of documentary heritage at the global, European and national levels is well recognized. These developments are changing the information and operating environments of memory organizations and public and private enterprises. These changes, in turn, are generating new requirements in archival science and records management education and research. This paper focuses on the implications of these changes for the planning, implementation and further development of an information studies curriculum. This curriculum development is considered crucial in order to respond to the new demands, and is also implicitly linked to the emerging Finnish information society. This article is based on Huotari, M.-L. and Valtonen, M.R., “Integrating Records and Archives Management with Information Studies in Finland”, in L. Ashcroft (ed.),Continuity, Culture, Competition—the Future of Library and Information Studies Education, Proceedings of the 4th British-Nordic Conference on Library and Information Studies 21–23 March 2001, Dublin, Ireland, pp. 249–254 (Dublin: MCB UP Limited, 2002).     

Role of Plasma MMP 9 levels in the Pathogenesis of Chronic Pancreatitis

Pancreatic fibrosis is a key pathological feature in the etiology of chronic pancreatitis that leads to obliteration of exocrine and endocrine pancreatic tissues and its replacement by fibrous tissue resulting in clinical manifestations. Matrix metalloproteinase 9 is a member of the MMP family that is also known as gelatinase B, degrades type IV collagen of extracellular matrix and basal membrane. The present study is aimed at evaluating the clinical significance of plasma concentration of MMP-9 in chronic pancreatitis. The samples were obtained from 112 chronic pancreatitis patients and an equal number of age and sex matched healthy controls. MMP-9 levels were quantitatively measured by ELISA assay. Statistical analysis was applied to test the significance of results. The present study revealed a significant increase of plasma MMP 9 levels in chronic pancreatitis patients compared to control subjects. Elevated levels were also observed in all the patient groups compared to control subjects with regard to sex, age, addictions etc. MMP-9 degrades the type IV collagens in normal basement membrane, which in turn activates the pancreatic stellate cells which promote the development of pancreatitic fibrosis. Thus, elevated plasma levels of MMP-9 may act as a susceptibility factor for the development of chronic pancreatitis.     

Cultural Endangerment and Education: Educational Analysis of Changes in Cultural Transmission of the Dongba Dance Tradition of the Naxi People in Lijiang,Yunnan, China

Many traditional ethnic cultural items are being endangered in China. Using the Dongba dance culture of the Naxi people as a case study, this paper seeks to analyze and interpret the endangerment of culture from an educational perspective, based on an analysis of the interaction between the cultural transmission mechanism of Dongba dance and the formal schooling of the Naxi people in Lijiang, China. By describing and comparing the traditional and current forms of Dongba dance transmission, the paper shows how the institution of formal education competes with older modes of cultural transmission, resulting in the endangerment of Dongba dance as a living cultural relic. So, in order to truly realize and improve the function of education in transmitting cultural heritage and to guarantee educational equity, we should prioritize sophisticated ethnic minority cultural items in the assessment and selection phases of education, grant them institutional cultural capital, and put greater effort into developing an appropriate school-based curriculum so that ethnic minority culture may be transmitted and inherited via formal schooling.     

hs-CRP and oxidative stress in young CAD patients: A pilot study

Premature coronary artery disease (CAD) is common in India. We, therefore, studied oxidative stress, dyslipidemia, and high sensitivity-C reactive protein (hs-CRP) levels in young CAD patients. Present study consisted of male CAD patients below 40 years and age and sex matched healthy controls (n=30 each). Fasting blood samples were analyzed for serum lipid profile, malondialdehyde, antioxidant enzymes and hs-CRP levels. Dyslipidemia was observed in 90% of the young CAD patients, of which 72.2% showed increased serum triglycerides and decreased HDL-cholesterol. LDL-cholesterol levels were high in 77.8%. Serum malondialdehyde and hs-CRP levels were increased significantly (p<0.0001) as compared to controls. hs-CRP levels were in high risk range in all the young patients. However, glutathione peroxidase activity was reduced significantly (p<0.05). Our data suggests that elevated hs-CRP levels along with dyslipidemia and oxidative stress adds to the predictive value of premature CAD in young Indians.     

Imagining transformative spaces: the personal–political sites of community archives

Although much has been written about formal archival spaces, little scholarship has addressed the physical spaces of community archives. This paper asks: How do community members imagine the physical spaces that steward identity-based community archives? Based on focus groups with more than 54 community archives users at five different community archives sites across Southern California, this paper examines how members of marginalized communities conceive of the physical space inhabited by community archives representing their communities. The sites explored range from a prominent location on a university campus, to storefronts, strip malls, and small cinderblock buildings. Yet across sites, users spoke about community archives spaces as symbolic and affectively moving locations. Many users described their community archives site as a “home-away-from-home,” marked by intergenerational dialog and a profound sense of belonging. For other users, community archives sites were described as “politically generative spaces” which foster dialog and debate about identity, representation, and activism and enable the community to envision its future. And yet, while the very existence of community archives is political, many participants felt that the full political potential of these sites is not yet realized. By listening to the voices of the communities represented and served by community archives, our research both indicates that a shift is warranted in archival metaphors of space and reveals how community archives are personally and politically transformative spaces for the communities they represent and serve.     

Traveling through: exploring doctoral demographics in archival studies

The growth of archival studies programs has prompted archival scholars to establish an international network for supporting collaborative research, curriculum development, and pedagogy. Doctoral education is key to the sustainability of such programs and the continuation of the network over time. We carried out longitudinal research to survey the population of doctoral students attending one or more Archival Education and Research Institutes (AERI), an annual meeting first held in 2009. Building on prior research on graduate archival education, we gathered demographic and qualitative data about doctoral students specializing in archival studies who are based in several countries including the USA. We sought to assess attendee motivations, guide conference planning, and help advance overall AERI objectives. Our study provides a baseline understanding of the disciplinary backgrounds, research directions, and specific professional development activities that doctoral students in archival studies pursued around the globe from 2013 to 2015. This paper argues that doctoral education should continue to be a particular subject of archival research and indicates how archival students’ range of academic interests is diversifying and strengthening the scholarly community.     

Integrating Undergraduate Peer Mentors into Liberal Arts Courses: A Pilot Study

This article presents research and narratives on the integration of course-based peer learning assistants into seven courses. A new curricular peer mentoring program was piloted in the 2005–2006 academic year in an interdisciplinary liberal arts college at a large Canadian research university. Undergraduate students enrolled in a practicum course which supported their learning while they collaborated with the “host instructor” of the course in which they served as peer mentor. Assistants’ roles varied and included individual tutoring, help via email, online discussion facilitation, small group facilitation, in-class presentation and discussion facilitation, and extracurricular study groups. Their integration into scheduled class activities resulted in participating students’ perception of enhanced learning. Data included peer mentors’ assignments, host instructor feedback, and student surveys.