Study of some common biochemical bone turnover markers in postmenopausal women

Markers of bone formation in serum include total and bone specific alkaline phosphatase, osteocalcin and Type 1 collagen carboxy terminal extension peptide. Bone resorption can be assessed by measuring plasma tartarate resistant acid phosphtase and urinary excretion of collagen degradation products: hydroxyproline, hydroxylysine glycosides and more recently the pyridinium crosslinks and associated peptides. We compared the excretion of hydroxyproline in women of reproductive age group to those of menopausal age group and found a significant difference in the two age groups. Urinary hydroxyproline was found to be significantly raised in post menopausal women. Thus hydroxyproline maybe used as the earliest indicator in the prognostic assessment of postmenopausal women of their risk of developing osteoporosis and fracture.     

Determining friction and effective loading for sled sprinting

Understanding the impact of friction in sled sprinting allows the quantification of kinetic outputs and the effective loading experienced by the athlete. This study assessed changes in the coefficient of friction (µ_k) of a sled sprint-training device with changing mass and speed to provide a means of quantifying effective loading for athletes. A common sled equipped with a load cell was towed across an athletics track using a motorised winch under variable sled mass (33.1–99.6 kg) with constant speeds (0.1 and 0.3 m · s^?1), and with constant sled mass (55.6 kg) and varying speeds (0.1–6.0 m · s^?1). Mean force data were analysed, with five trials performed for each condition to assess the reliability of measures. Variables were determined as reliable (ICC > 0.99, CV < 4.3%), with normal-force/friction-force and speed/coefficient of friction relationships well fitted with linear (R² = 0.994–0.995) and quadratic regressions (R² = 0.999), respectively (P < 0.001). The linearity of composite friction values determined at two speeds, and the range in values from the quadratic fit (µ_k = 0.35–0.47) suggested µ_k and effective loading were dependent on instantaneous speed on athletics track surfaces. This research provides a proof-of-concept for the assessment of friction characteristics during sled towing, with a practical example of its application in determining effective loading and sled-sprinting kinetics. The results clarify effects of friction during sled sprinting and improve the accuracy of loading applications in practice and transparency of reporting in research.     

The new organization and implications for training

In our work over the past 15 years, we have been guided by a premise, right or wrong, that fundamental changes in how organizations work require fundamental changes in how we think and interact. Changes in the “outer world” do not necessarily produce change in the “inner world”… I am skeptical of what can be accomplished by changes in structure alone.… What leads us to believe that lots of local managers, focused on their own profits, will be any more far‐sighted than a few corporate managers focused on corporate profits? Will they be any better at systems thinking? … What good is it to have more free movement of information if people cannot discuss the information that is most important, but that is also the most threatening? (Sugarman, 1997).     

Early life stress and perceived social isolation influence how children use value information to guide behavior

Learning the value of environmental signals and using that information to guide behavior is critical for survival. Stress in childhood may influence these processes, but how it does so is still unclear. This study examined how stressful event exposures and perceived social isolation affect the ability to learn value signals and use that information in 72 children (8–9 years; 29 girls; 65.3% White). Stressful event exposures and perceived social isolation did not influence how children learned value information. But, children with high stressful event exposures and perceived social isolation were worse at using that information. These data suggest alterations in how value information is used, rather than learned, may be one mechanism linking early experiences to later behaviors.     

In/Out: Hong Kong Tongzhi Creative Workshop and Exhibition

Abstract

Critics of postcolonial theory have provided this theory with a genealogy in which it appears as the poisoned fruit of a period when revolutionary energies were ebbing and in retreat. This essay seeks to provide an alternative genealogy, suggesting that the Subaltern Studies project, and postcolonial theory more generally, were enabled and in important ways shaped by the Maoist upsurge in some parts of India in the latter 1960s and early 1970s. The critiques of modernity, of nationalism and the nation‐state, and of homogenizing narratives of progress which mark, and in the eyes of its critics, mar these intellectual currents, far from being reflections of their disassociation from radical politics, are here presented as the indirect outcome of a profound cultural and intellectual shift, which has been the consequence of the Naxalite movement of this period. This alternative genealogy proceeds through an alternative reading of the Naxalite movement. This essay asks why this movement was so important, given that its ideology was naïve, and its political successes short‐lived. The Naxalite strategy of ‘annihilating’ feudal landlords, and the urban ‘statue‐smashing’ campaign of Naxalite youth in 1970 – commonly regarded and condemned as juvenile and ultra‐leftist – are here instead interpreted as an incipient critique of aspects of Marxist theory, a critique subsequently given more explicit and elaborate exposition in the writings of the Subaltern Studies group, and in postcolonial theory.     

Associations Between Early Life Stress and Gene Methylation in Children

Children exposed to extreme stress are at heightened risk for developing mental and physical disorders. However, little is known about mechanisms underlying these associations in humans. An emerging insight is that children's social environments change gene expression, which contributes to biological vulnerabilities for behavioral problems. Epigenetic changes in the glucocorticoid receptor gene, a critical component of stress regulation, were examined in whole blood from 56 children aged 11–14 years. Children exposed to physical maltreatment had greater methylation within exon 1_F in the NR3C1 promoter region of the gene compared to nonmaltreated children, including the putative NGFI‐A (nerve growth factor) binding site. These results highlight molecular mechanisms linking childhood stress with biological changes that may lead to mental and physical disorders.     

An Investigation of the Language Demands in Content Assessments for English Language Learners

The purpose of the present study is to examine the language characteristics of a few states' large-scale assessments of mathematics and science and investigate whether the language demands of the items are associated with the degree of differential item functioning (DIF) for English language learner (ELL) students. A total of 542 items from 11 assessments at Grades 4, 5, 7, and 8 from three states were rated for the linguistic complexity based on a developed linguistic coding scheme. The linguistic ratings were compared to each item's DIF statistics. The results yielded a stronger association between the linguistic rating and DIF statistics for ELL students in the “relatively easy” items than in the “not easy” items. Particularly, general academic vocabulary and the amount of language in an item were found to have the strongest association with the degrees of DIF, particularly for ELL students with low English language proficiency. Furthermore, the items were grouped into four bundles to closely look at the relationship between the varying degrees of language demands and ELL students' performance. Differential bundling functioning (DBF) results indicated that the exhibited DBF was more substantial as the language demands increased. By disentangling linguistic difficulty from content difficulty, the results of the study provide strong evidence of the impact of linguistic complexity on ELL students' performance on tests. The study discusses the implications for the validation of the tests and instructions for ELL students.