Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.     

Performance improvement of a crumb rubber modified bitumen using recycled glass powder

In this study, the efficiency of bitumen and asphalt mixtures modified with crumb rubber （CR） and recycled glass powder （RGP） is evaluated. From an environmental point of view, the application of RGP in asphalt mixtures is considered beneficial since it prevents accumulation of waste glass in the natural environment. Rheological and mechanical properties of modified bitumen samples were investigated by laboratory methods such as bitumen conventional tests and dynamic shear rheometer （DSR）, and also by asphalt mixture performance tests including Marshall stability, indirect tensile strength （ITS）, compressive strength, and indirect tensile stiffness modulus. The results showed that the application of RGP in place of CR has no negative impact on the efficiency of bitumen and asphalt mixtures and even improves their engineering properties except for the toughness index （TI）. Moreover, a modification with 5% CR and 5% RGP in asphalt mixtures results in the best overall performance.     

Engendering a culture of thinking in a culture of performativity: the challenge of mediating tensions in the Singaporean educational system

Among the major policies that have been implemented to ensure its continued success, Thinking Schools, Learning Nation (TSLN) has been described as the ‘big bang of educational reforms’ in Singapore. However, while the policy aims to develop critical thinkers in school leavers, the corporatisation of education in the shape of structures such as the school excellence model seems to be at odds with TSLN. This paper argues that these structures unwittingly engender a culture of performativity among schools, marginalising the central outcome of its initiative that entails developing a culture of thinking and thinkers. The tension is further exacerbated by the larger rationalities that have shaped Singapore and the pragmatic and instrumental philosophy which underpins its educational system. The tensions generated by the clash between intended (culture of thinking) and engendered culture (culture of performativity) present the challenge of mediation for the system on its path to realising TSLN.     

H∞ dynamic observer-based fuzzy integral sliding mode control with input magnitude and rate constraints

This paper focuses on a systematic constrained fuzzy integral sliding mode controller design for a class of uncertain discrete-time nonlinear systems which can be represented as Takagi-Sugeno (T-S) fuzzy models. The contributions are to consider constraints on the control input amplitude and control input amplitude rate and to extend the existing pole-placement design technique for designing gain matrices of the fuzzy sliding surface. Moreover, a dynamic-gain observer along with ${\mathit{H}}_{\infty }$ performance is proposed for attenuating disturbance, which generalizes the existing results on the Proportional Observer (PO), the Proportional Integral Observer (PIO) and the dynamic observer (DO). Finally, the dynamic-observer-based constrained fuzzy integral sliding mode controller is designed. All the proposed design conditions are represented in terms of LMIs-based ones. The methods are studied for not only single-input single-output (SISO) but also multi-input multi-output (MIMO) systems. In the end, the proposed approaches are evaluated on practical and numerical systems to illustrate the superiority of the proposed control scheme.     

An interdisciplinary overview and intelligent control of human prosthetic eye movements system for the emotional support by a huggable pet-type robot from a biomechatronical viewpoint

Despite active research and significant progress in the last three decades on control of human eye movements, it remains challenging issue due to its applications in prosthetic eyes and robotics. Till now, no considerable investigation of this subject is presented in the interdisciplinary sciences. The goal of this paper is to present a distinguished survey of existing literature on the intelligent control of the human eye movements system applied in a huggable pet-type robot as a biomechatronic system.In this study, the basic knowledge of human eye movements control is explained to show how the neural networks in the brainstem control the human eye movements. The geometry and model of human eye movements system are investigated and this system is considered as a nonlinear control system. The specified model may only be an academic exercise. It can have scientific importance in understanding of the human movement system in general. Also, it can be useful for robotics.Intelligent methods such as artificial neural networks and fuzzy neural networks are proposed to control the human eye movements and numerical simulations are presented. It is discussed that the intelligent controls applied to control of human eye movements system are emulated from the neural controls in biological system.     

Rorty's Approach to Cultural Difference: The Conflict between Solidarity and Procedural Liberalism

Although Richard Rorty's controversial thought has been the subject of many works, there has not been much discussion about his approach to cultural difference. The purpose of this article is to examine how Rorty sees cultural differences philosophically and how he deals with them politically. For him, rationality, morality and even the scope of moral responsibility towards others are defined in terms of solidarity with a particular community and ‘ethnocentrism’, rather than in terms of a universal and metaphysically derived set of criteria. It can be argued that since language, language games and values are mainly components of culture, the latter is one of the most significant communities with which Rorty is concerned, though he is not explicit about it. Nevertheless, Rorty does not think that the moral and philosophical significance of communities, particularly cultural communities, should be reflected in politics. The main argument of the article is that there is an unresolved tension in Rorty's thought between philosophical, moral and emotional attribution of significance to communities and arguably cultural communities, and a disregard for them in the political sphere. This paves the way for outlining an approach to cultural difference that is more just and even more in harmony with Rorty's own philosophy.     

Thyroid hormones status during pregnancy in normal Iranian women

Pregnancy is associated with significant, but reversible changes in thyroid function studies, which are among the most profound seen as a result of a normal physiologic state. The present study was carried out to find out alterations in thyroid function tests in each trimester in normal pregnant women as compared to non-pregnant women in Tabriz-Iran. A case-control study designed with 229 normal pregnant women that randomly selected from the first (64 samples), the second (92 samples), and the third (73 samples) trimesters and 250 randomly selected non-pregnant healthy female controls. Age range in both groups was 16–40 years. Thyroid function tests carried out by measuring serum levels of thyroid stimulating hormone (TSH), free and total thyroxin (FT₄, TT₄), and free and total triiodothyronine (FT₃, TT₃) by commercially available radio immunoassay kits. We found that mean TT₄ increased progressively during pregnancy. Our study showed increasing in serum levels of TT₃ in the second trimester and then declining during the third trimester compared with non-pregnant women. We showed that FT₄ strongly decreased during the third trimester. Free T₃ showed declining in the second and third trimesters. Mean TSH did not show significant difference in each trimester compared with non-pregnant women. The thyroid function tests in pregnancy should be interpreted against gestational age-related reference intervals to avoid mis-interpretation of thyroid function during pregnancy.     

Restrictions of the derivatives of positive real functions

Dissipative operators appear in abundance in the study of dynamical systems. In the classical circuit theory they are presented as Positive Real Functions. The coefficients of the Taylor expansion of PRF (driving-point impedance or admittance) must satisfy certain derived inequalities. A method is suggested for obtaining restrictions of the derivative of Positive Real Functions (Dissipative Operators).