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911.
912.
Reema George Harikrishnan Sivadasanpillai Narayani Jayakumari Anugya Bhatt Jissa V. Thulaseedharan Jaganmohan A. Tharakan 《Indian journal of clinical biochemistry : IJCB》2016,31(3):302-309
Thrombotic risk factors may contribute to premature coronary artery disease (CAD), in addition to the conventional risk factors. There is paucity of data on studies evaluating the role of thrombotic factors in premature CAD in Indian patients. Thus a case–control study was performed to evaluate the role of thrombotic and atherogenic factors in young patients with angiographically proven CAD who are on treatment with statins and anti-platelet drugs. 152 patients (≤55 years) with angiographically proven CAD and 102 asymptomatic controls were recruited. Clinical and biochemical data were obtained in both groups. Blood levels of thrombotic factors-fibrinogen, antithrombin-III, tissue-plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1), von-Willebrand factor (v-WF), lipoprotein(a) [Lp(a)] and homocysteine were analyzed. Patients had high levels of conventional CAD risk factors (diabetes mellitus, smoking, hypertension, dyslipidemia and positive family history) compared to controls. Logistic regression analysis revealed that low antithrombin-III (odds ratio/OR 11.2; 95 % confidence interval/CI 2.29–54.01), high fibrinogen (OR 6.04; 95 % CI 1.09–33.21) and high Lp(a) (OR 4.54; 95 % CI 0.92–22.56), as important, independent risk factors in patients. PAI-1(OR 0.15; 95 % CI 0.03–0.69) levels were significantly lower in patients. But other thrombotic risk factors studied (t-PA, v-WF and homocysteine) were comparable among patients and controls. The treatment using statins and anti-platelet drugs might be contributing to the control of some of the thrombotic risk factors. The strategies aiming at lowering the levels of thrombotic risk factors along with conventional risk factors may be useful in primary and secondary prevention of CAD. 相似文献
913.
Dietary restriction (DR) also called dietary control or calorie restriction is reported to have many advantages with regard
to human health. It leads to suppression of obesity, mitigates free radicals and increases available antioxidants which are
accounted for extending the life span of individuals. DR is also reported to induce synthesis of heat shock proteins in animals
as a control mechanism against stress. Further, it is known to play a significant role in decreasing toxicity and lethality
due to a variety of toxic chemicals and drugs by stimulating tissue repair damaged by the toxicants leading to restoration
of intact organ and its functions. Moreover, extensive work done on animals indicate DR has an important role in suppressing
certain types of cancer. In this review an effort is made to highlight the various advantages of DR from the point of human
health perspective. 相似文献
914.
论面向提高组织绩效的知识管理 总被引:3,自引:0,他引:3
知识管理的根本目的是提高组织的绩效和竞争力。本文从有效的知识管理需要关注的问题、技术基础设施和内容基础设施等3个方面论述了面向提高组织绩效的知识管理问题。 相似文献
915.
916.
Ishrat Kareem S. A. Jaweed J. S. Bardapurkar V. P. Patil 《Indian journal of clinical biochemistry : IJCB》2004,19(2):124-127
The present study was undertaken in 100 subjects, 30 diabetics without complication (group I), 40 diabetics with retinopathy
(group II) and 30 non diabetic as normal control group (group III). Blood sugar levels, magnesium, cholesterol and triglyceride
were analyzed from plasma and serum. The results were correlated with degree of diabetic control from the levels of glycosylated
hemoglobin. Serum magnesium levels in group II were found to be significantly lowered than in group I. There was also significant
difference in magnesium levels of group I and group III. We found a significant correlation between the glycosylated hemoglobin
and magnesium levels in our study.
The results also indicate that the patients with diabetic retinopathy showed significant rise in serum cholesterol and triglyceride.
Probably hypomagnesemia and increased serum cholesterol and triglyceride levels are responsible for microvascular changes
in diabetes leading to retinopathy. The purpose of this study was thus to gather information about the degree of control of
diabetes and magnesium status. 相似文献
917.
918.
Curcumin is a natural anti-inflammatory and antioxidant with several potential health benefits. Although it has been examined in several metals toxicity studies, but its role in the protection against copper toxicity has not been investigated. In this study; the detoxification and antioxidant effect of curcumin were examined to determine its prophylactic/therapeutic role experimentally in rats. Forty albino rats were divided into five groups; control, CuSO4 (4 mg/kg body weight), curcumin (80 mg/kg body weight), curcumin post-treatment (CuSO4 for 15 days followed by curcumin for the next 15 days) and curcumin co-treatment (CuSO4 plus curcumin for 30 days). All rats were treated orally by stomach tube for 30 days/once a day. Changes were observed in hepatic marker enzymes such as: aspartate aminotransferase (AST), alanine transaminase-(ALT), alkaline phosphatase (ALP) and gamma-glutamyltransferase (GGT), besides the serum total protein, urea and creatinine. Concentration of liver and kidney antioxidants such as: catalase (CAT), superoxide dismutase (SOD), reduced glutathione-(GSH) and malondialdehyde (MDA) were measured. An increased in the activities of liver marker enzymes, urea, creatinine and the MDA contents were detected after exposure to CuSO4. Meanwhile, the activities of serum total protein, hepatic and renal antioxidants were decreased. Changes in all biochemical parameters were alleviated by the post-treatment and co-treatment of curcumin. Our finding suggests that the curcumin showed protective effects on CuSO4-induced hepatotoxicity and nephrotoxicity. 相似文献
919.
Mark Coeckelbergh 《Ethics and Information Technology》2007,9(3):219-231
Many philosophical and public discussions of the ethical aspects of violent computer games typically centre on the relation
between playing violent videogames and its supposed direct consequences on violent behaviour. But such an approach rests on
a controversial empirical claim, is often one-sided in the range of moral theories used, and remains on a general level with
its focus on content alone. In response to these problems, I pick up Matt McCormick’s thesis that potential harm from playing
computer games is best construed as harm to one’s character, and propose to redirect our attention to the question how violent
computer games influence the moral character of players. Inspired by the work of Martha Nussbaum, I sketch a positive account
of how computer games can stimulate an empathetic and cosmopolitan moral development. Moreover, rather than making a general
argument applicable to a wide spectrum of media, my concern is with specific features of violent computer games that make
them especially morally problematic in terms of empathy and cosmopolitanism, features that have to do with the connections
between content and medium, and between virtuality and reality. I also discuss some remaining problems. In this way I hope
contribute to a less polarised discussion about computer games that does justice to the complexity of their moral dimension,
and to offer an account that is helpful to designers, parents, and other stakeholders.
An earlier version of this paper was presented at the ACLA 2006 conference in Princeton, 25 March 2006. 相似文献
920.
M. Maneesh Sanjiba Dutta Amit Chakrabarti D M Vasudevan 《Indian journal of clinical biochemistry : IJCB》2007,22(1):138-142
Infertility is well-established harmful effect in chronic alcoholism and so far, there is no effective treatment for this
condition. The study was conducted to determine the effects of alpha tocopherol on ethanol induced testicular injuries in
male albino rats of Wistar strain. Five groups (n=6) of animals were used. Group I served as control. Group II received daily
1.6g ethanol/kg body weight/day for 4 weeks orally. Group III received 1.6g ethanol+80mg alpha tocopherol/kg body weight/day
for four weeks orally. Group IV received 1.6g ethanol/kg body weight for/day 4 weeks and followed by 80mg alpha tocopherol/kg
body weight/day for four weeks orally. Group V received 1.6g ethanol/kg body weight/day orally for 4 weeks, followed by 4
weeks abstinence. Twently-four hours after the last treatment the rats were sacrificed using anesthetic ether. Testes were
removed and used for the estimation of extent of lipid peroxidation and tissue levels of antioxidants and steroidogenic enzymes.
Alpha tocopherol treatment increased the activities of testicularΔ
5, 3β-HSD. Moreover, the treatment was also associated with significant decrease in testicular oxidative stress. Ethanol-induced
oxidative stress and decreased steroidogenesis can be reversed by treatment with alpha tocopherol. 相似文献