Molecularly imprinted polymers as the extracted sorbents of clenbuterol ahead of liquid chromatographic determination

A pre-treatment methodology for clenbuterol hydrochloride (CLEN) isolation and enrichment in a complex matrix environment was developed through exploiting molecularly imprinted polymers (MIPs). CLEN-imprinted polymers were synthesized by the combined use of ally-β-cyclodextrin (ally-β-CD) and methacrylic acid (MAA), allyl-β-CD and acrylonitrile (AN), and allyl-β-CD and methyl methacrylate (MMA) as the binary functional monomers. MAA-linked allyl-β-CD MIPs (M-MAA) were characterized by Fourier transform-infrared (FT-IR) spectroscopy and a scanning electron microscope (SEM). Based upon the results, M-MAA polymers generally proved to be an excellent selective extraction compared to its references: AN-linked allyl-β-CD MIPs (M-AN) and MMA-linked allyl-β-CD MIPs (M-MMA). M-MAA polymers were eventually chosen to run through a molecularly imprinted solid-phase extraction (MISPE) micro-column to enrich CLEN residues spiked in pig livers. A high recovery was achieved, ranging from 91.03% to 96.76% with relative standard deviation (RSD) ≤4.45%.     

In vitro remineralization of hybrid layers using biomimetic analogs

Resin-dentin bond degradation is a major cause of restoration failures. The major aim of the current study was to evaluate the impact of a remineralization medium on collagen matrices of hybrid layers of three different adhesive resins using nanotechnology methods. Coronal dentin surfaces were prepared from freshly extracted premolars and bonded to composite resin using three adhesive resins (FluoroBond II, Xeno-III-Bond, and iBond). From each tooth, two central slabs were selected for the study. The slabs used as controls were immersed in a simulated body fluid (SBF). The experimental slabs were immersed in a Portland cement-based remineralization medium that contained two biomimetic analogs (biomineralization medium (BRM)). Eight slabs per group were retrieved after 1, 2, 3, and 4 months, respectively and immersed in Rhodamine B for 24 h. Confocal laser scanning microscopy was used to evaluate the permeability of hybrid layers to Rhodamine B. Data were analyzed by analysis of variance (ANOVA) and Tukey’s honest significant difference (HSD) tests. After four months, all BRM specimens exhibited a significantly smaller fluorescent area than SBF specimens, indicating a remineralization of the hybrid layer (P≤0.05). A clinically applicable biomimetic remineralization delivery system could potentially slow down bond degradation.     

Ideology or reality? The awareness of educational aims and activities amongst German and Norwegian participants of the first summer and winter Youth Olympic Games

This paper explores the awareness of the young German and Norwegian participants in the Youth Olympic Games (YOG) of the additional educational mission of this new event, implemented by the International Olympic Committee. Among the questions considered are whether the nature of the event contradicts its claimed intention to focus on both competition and education. Data were collected through a set of interviews with young German and Norwegian athletes at the Singapore YOG in the summer of 2010 and the Innsbruck YOG in the winter of 2012. The findings revealed (1) a focus on elite sport by athletes and their coaches, while the educational aims were considered secondary; (2) that it was problematic for the young participants to focus on education in a high-performance event. The overall conclusion was that the YOG have had only limited success in achieving the educational ambitions of the Olympic Movement.     

A study of airfoil parameterization,modeling, and optimization based on the computational fluid dynamics method

An excellent airfoil with a high lift-to-drag ratio may decrease oil consumption and enhance the voyage. Based on NACA 0012, an improved airfoil is explored in this paper. The class/shape function transformation has been proved to be a good method for airfoil parameterization, and in this paper it is modified to improve imitation accuracy. The computational fluid dynamics method is applied to obtain numerically the aerodynamic parameters of the parameterized airfoil, and the result is proved credible by comparison with available experimental data in the open literature. A polynomial-based response surface model and the uniform Latin hypercube sampling method are employed to decrease computational cost. Finally, the nonlinear programming by quadratic Lagrangian method is utilized to modify the multi-island genetic algorithm, which has an improved optimization effect than the method used on its own. The obtained result shows that the modified class/shape function transformation method produces a better imitation of an airfoil in the nose and tail regions than the original method, and that it will satisfy the tolerance zone of the model in a wind tunnel. The response surface model based on the uniform Latin hypercube sampling method gives an accurate prediction of the lift-to-drag ratio with changes in the design variables. The numerical result of the flow around the airfoil shows reasonable agreement with the experimental data graphically and quantitatively. Ultimately, an airfoil with better capacity than the original one is acquired using the multi-island genetic algorithm based nonlinear programming by quadratic Lagrangian optimization method. The pressure contours and lift-to-drag ratio along with the attack angle have been compared with those of the original airfoil, and the results demonstrate the strength of the optimized airfoil. The process for exploring an improved airfoil through parameterization to optimization is worth referencing in future work.     

Chinese middle school teachers’ preferences regarding performance evaluation measures

Teacher performance evaluation currently is receiving unprecedented attention from policy makers, scholars, and practitioners worldwide. This study is one of the few studies of teacher perceptions regarding teacher performance measures that focus on China. We employed a quantitative dominant mixed research design to investigate Chinese teachers’ preferences for teacher performance measures and the possible reasons for their preferences. Considering the quantitative results, the surveyed Chinese teachers identified fulfillment of additional roles, collaboration with faculty and staff, and students’ test scores as the most important measures for performance evaluation. Qualitatively, the most important measures that the surveyed teachers reported were the teacher’s morality, workload, and students’ test scores.     

A topography of free kicks in soccer

ABSTRACT

This study investigates the spatial relationship of performance variables for soccer free kicks. In order to suggest ways in which players might optimise their performance, we collected data from free kicks (<35 m to goal line) of two German Bundesliga seasons (2013/14, 2014/15) (n = 1624). In the analysis, we applied the ISO-map approach using colour gradients to visualise the mean values of a variable on a 2D-map of the pitch. Additionally, variograms were used to describe the degree of spatial dependence of the free kick variables. Results show that DENSITY, TYPE OF PLAY, PLAYERS IN WALL, DISTANCE TO WALL and RULE VIOLATION were strongly spatially dependent. Centrality and proximity to the goal increased the variables PLAYERS IN WALL, RULE VIOLATIONS and INTERRUPTION TIME, and the ratio of goals scored increased from 5.9% (central far) to 10.9% (central near). In 70.9% of the shots, players preferred a switched laterality, which did not result in a higher success rate. Furthermore, there was no statistical advantage for the defensive team when DISTANCE TO WALL was below 9.15 m or when there was a RULE VIOLATION. Crosses had a success rate (i.e., first controlled ball contact after the cross) of 20.8%. Played with natural laterality, they were 5% more successful than with switched laterality. Crosses from the right side outside the penalty box were 10% more successful than from the left side. Therefore, it might be worthwhile practising the defence of balls coming from this side.     

Konsumverhalten von Eventbesuchern der Olympischen Jugend-Winterspiele am Beispiel Innsbruck 2012

The aim of this article is to gain insights into the economic impacts of the Winter Youth Olympic Games (YOG). Taking the example of Innsbruck 2012 (YOG 2012)—the first ever Winter YOG—the economic dimension of the event is comprised by calculating the primary economic impulse as well as the induced economic impulse (total economic effect). For the purpose of this study the region (Tirol) and the period of time (13^th to 22^th January 2012) were chosen.     

‘The Sole Anti-Democratic Federation in the Entire Olympic Movement’: Early International Association of Athletics Federations Development Initiatives Between Commercialization and Democratization, 1974–1987

Abstract

Studies on the development of Olympic Solidarity as a tool of the International Olympic Committee (IOC) to enable National Olympic Committees of developing countries access to resources and influence in the Olympic Movement exist. However, historical scholarship has relatively neglected the development of aid programs by International Federations to explain how they made use of resources to gain influence in international sport politics. Based on extensive multi-national and multi-lingual archival research in the archives of the International Association of Athletics Federation (IAAF) and the German Sport University Cologne, this article explores the establishment and development of the IAAF‘s Technical Aid Program, which had been installed in 1974. Referencing a large amount of previously unknown protocols and written correspondence, the paper critically discusses the IAAF‘s development activities in light of two parallel occurring processes that shaped the federation’s character in the 1970s and 1980s decisively: its increasing commercialization and its path towards democratization in its voting system. It is argued that the IAAF development programs served as a tool to enforce commercial and sport political interests whilst the nature of support remained without clear guidance until the mid-1980s.     

Motorische Leistungsfähigkeit von Kindern und Jugendlichen in Deutschland

Motor performance is an important health resource. Review articles revealed a decline of motor performance of approximately 10?% between 1975 and 2006. In the past most of the data available for such comparisons came from ad hoc studies with non-standardized methods. Within the framework of the ”Motorik-Modul“ (MoMo) study as part of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS), it is possible for the first time to directly compare two cohorts in the ages of 4–17 years in a nationally representative database for Germany. The aim of this article is to report changes in motor performance of children and adolescents in the time period 2003–2006 (cohort baseline n = 4528) compared to 2009–2012 (cohort wave 1, n = 2820). Overall, it is clearly shown that the motor performance of children and adolescents in Germany did not decrease within the observational period of 6 years. The comparison of mean values of the baseline cohort compared to those of wave 1 showed that 28 out of 52 mean values of the two cohorts with a high probability did not differ based on 95?% confidence intervals (CI). In 24 out of the 52 mean values positive changes could be noted based on the individual 95?% CI values. There were more positive changes in primary school aged children than in other age groups. Within these positive changes, most effect sizes were small to medium. The results indicate that recent activities aiming at elevating motor performance levels may have started to make an impact and should be expanded, also in secondary schools. The comparative cohort study presented in this article is currently being checked by the ongoing MoMo wave 2 survey of 2014–2017.