Social and intellectual dimensions of entrepreneurship

Entrepreneurship is above all the ability to perceive opportunities and to tap resources necessary to exploit them. In defining entrepreneurship as ability, one accentuates the fact that it does not have to be equally distributed among people. It can be both learned and taught. However, it should be learned and taught because what is intended is the development of a special capacity. Not only is the skill to see opportunities (in other words to recognize possibilities unseen by others) developed, but so too is the competence (or power) to tap resources necessary to exploit them. A successful entrepreneur not only needs sufficient skill to recognize emerging future patterns (which is the essence of opportunity detection), but also the aptitude to figure out whether or not and how he or she is able to tap the necessary resources. None of these factors can be absent—neither opportunity nor resources. They should be observed and reflected upon simultaneously.     

Development and validation of a low cost blood filtration element separating plasma from undiluted whole blood

Clinical point of care testing often needs plasma instead of whole blood. As centrifugation is labor intensive and not always accessible, filtration is a more appropriate separation technique. The complexity of whole blood is such that there is still no commercially available filtration system capable of separating small sample volumes (10-100 μl) at the point of care. The microfluidics research in blood filtration is very active but to date nobody has validated a low cost device that simultaneously filtrates small samples of whole blood and reproducibly recovers clinically relevant biomarkers, and all this in a limited amount of time with undiluted raw samples. In this paper, we show first that plasma filtration from undiluted whole blood is feasible and reproducible in a low-cost microfluidic device. This novel microfluidic blood filtration element (BFE) extracts 12 μl of plasma from 100 μl of whole blood in less than 10 min. Then, we demonstrate that our device is valid for clinical studies by measuring the adsorption of interleukins through our system. This adsorption is reproducible for interleukins IL6, IL8, and IL10 but not for TNFα. Hence, our BFE is valid for clinical diagnostics with simple calibration prior to performing any measurement.