Creatine kinase,myosin heavy chains and magnetic resonance imaging after eccentric exercise

The aim of this study was to examine the relationship between myosin heavy chain (MHC) release as a specific marker of slow-twitch muscle fibre breakdown and magnetic resonance imaging (MRI) of skeletal muscle injury after eccentric exercise. The effects of a single series of 70 high-intensity eccentric contractions of the quadriceps femoris muscle group (single leg) on plasma concentrations of creatine kinase and MHC fragments were assessed in 10 young male sport education trainees before and 1 and 4 days after exercise. To visualize muscle injury, MRI of the loaded thigh was performed before and 4 days after the eccentric exercise. All participants recorded an increase ( P ? 0.05) in creatine kinase after exercise. In five participants, T2 signal intensity was unchanged post-exercise compared with pre-exercise and MHC plasma concentration was normal; however, they showed an increase ( P ? 0.05) in creatine kinase after exercise. For the remaining five participants, there was an increase in T2 signal intensity of the loaded vastus intermedius and vastus lateralis. These changes in MRI were accompanied by an increase in MHC plasma concentration ( P ? 0.01) as well as an increase in creatine kinase ( P ? 0.01). We suggest that changes in MRI T2 signal intensity after muscle damage induced by eccentric exercise are closely related to damage to structurally bound contractile filaments of some muscle fibres. Additionally, MHC plasma release indicates that this damage affects not only fast-twitch fibres but also some slow-twitch fibres.     

The public understanding of nanotechnology in the food domain: the hidden role of views on science, technology, and nature

In spite of great expectations about the potential of nanotechnology, this study shows that people are rather ambiguous and pessimistic about nanotechnology applications in the food domain. Our findings are drawn from a survey of public perceptions about nanotechnology food and nanotechnology food packaging (N = 752). Multinomial logistic regression analyses further reveal that knowledge about food risks and nanotechnology significantly influences people's views about nanotechnology food packaging. However, knowledge variables were unrelated to support for nanofood, suggesting that an increase in people's knowledge might not be sufficient to bridge the gap between the excitement some business leaders in the food sector have and the restraint of the public. Additionally, opposition to nanofood was not related to the use of heuristics but to trust in governmental agencies. Furthermore, the results indicate that public perceptions of nanoscience in the food domain significantly relate to views on science, technology, and nature.     

Resilience to adult psychopathology following childhood maltreatment: evidence from a community sample

OBJECTIVE: Child abuse is an important risk for adult psychiatric morbidity. However, not all maltreated children experience mental health problems as adults. The aims of the present study were to address the extent of resilience to adult psychopathology in a representative community sample, and to explore predictors of a good prognosis. METHODS: Data are drawn from a follow-up of the Isle of Wight study, an epidemiological sample assessed in adolescence and at midlife. Ratings of psychiatric disorder, peer relationships and family functioning were made in adolescence; adult assessments included a lifetime psychiatric history, personality and social functioning assessments, and retrospective reports of childhood sexual and physical abuse. RESULTS: Ten percent of individuals reported repeated or severe physical or sexual abuse in childhood. Prospective measures revealed increased rates of adolescent psychiatric disorders in this group. Rates of adult psychopathology were also high. A substantial minority of abused individuals reported no mental health problems in adult life. Resilience of this kind was related to perceived parental care, adolescent peer relationships, the quality of adult love relationships, and personality style. CONCLUSION: Good quality relationships across childhood, adolescence and adulthood appear especially important for adult psychological well being in the context of childhood abuse.     

Reports on Books

OfSTED's criteria for inspection are published and available to all. However, it is quite possible that there will be a mismatch between schools' interpretations of what OfSTED means by good practice in primary mathematics and those of the inspectors who come to inspect them. The research reported here focuses on the responses of a small set of primary schools to the inspection of their mathematics: their anticipation of issues, their expectations of what would be found and their views of how the inspection would contribute to the development of good practice. Inspectors' reports seemed frequently to match the expectations of the schools. Interpretations appeared to coincide, but in some cases there appeared to be mismatch and disagreement which raised questions about expertise or interpretations of both inspector and mathematics co-ordinator and might, in turn, affect the development of mathematics following inspection.     

Metacognitive monitoring in university classes: anticipating a graded vs. a pass-fail test affects monitoring accuracy

Three field studies tested the hypothesis that anticipating a graded test as opposed to a pass-fail test enhances metacognitive monitoring. Participants were teacher candidates who completed a mid-term and a final test in psychology courses. Each participant chose whether the result of the final test should be evaluated with one of five grades or with a pass-fail decision. In both tests, participants answered true–false inference items about the contents of the course and indicated their confidence in the correctness of each answer. When a graded test was expected, confidence and the absolute accuracy of the confidence judgments increased and bias decreased to a greater extent than when a pass-fail decision was expected. However, expecting a grade increased participants’ confidence not only in correct answers but also in incorrect answers (Study 1). Feedback and instructions emphasizing the importance of accurate discrimination between correct and incorrect answers did not weaken this effect (Study 2). The generalizability of the findings was investigated by reanalyzing the test results of participants in eight other psychology courses (Study 3). The results are discussed in terms of the motivational consequences of grading.     

A high resolution laser scanning model of the Roman theater in Pinara,Turkey – comparison to previous measurements and search for the causes of damage

The archaeological site Pinara, southwest Turkey, which includes several remarkable objects of cultural heritage, has been the focus of several previous archaeoseismic studies. One of these examined the setting of the Roman theater in the east of Pinara by a lidar survey. A gross inclination of the stone rows of the auditorium of 0.81° towards N 314°E was interpreted as a consequence of recent coseismic tectonic movements. A new survey of the theater with a terrestrial phase laser scanner is the basis for a model with 15 times higher resolution and 28 times more data points. Parallel to the fieldwork in this study, the process and accuracy of the leveling of the 3D point clouds produced by the scanner was tested in a series of experiments. Based on the orientation of the blocks forming the seats of the theater, we suggest six sections with changing average inclination of the seats and a fault line separating a northern and a southern section. While the previously found overall inclination of the auditorium is confirmed by the new model and the dip direction agrees, the inclination is 0.58° compared to previously determined 0.81°. The almost perfect increase of inclination with the height of the first 10 entire seating rows and the nearly constant inclination from row 11 onward, makes systematic measurement errors during the construction a possible cause. This is an alternative scenario to the interpretation of a coseismic displacement of the conglomerate block on which the theater was built.     

Does Touching Real Objects Affect Learning?

Educational Psychology Review - Based on theories of multimedia learning, the present study investigated whether the haptic sense serves as an additional channel to enhance the learning experience...     

Cinematic Rendering in Anatomy: A Crossover Study Comparing a Novel 3D Reconstruction Technique to Conventional Computed Tomography

Integration of medical imaging into preclinical anatomy courses is already underway in many medical schools. However, interpretation of two-dimensional grayscale images is difficult and conventional volume rendering techniques provide only images of limited quality. In this regard, a more photorealistic visualization provided by Cinematic Rendering (CR) may be more suitable for anatomical education. A randomized, two-period crossover study was conducted from July to December 2018, at the University Hospital of Erlangen, Germany to compare CR and conventional computed tomography (CT) imaging for speed and comprehension of anatomy. Sixteen students were randomized into two assessment sequences. During each assessment period, participants had to answer 15 anatomy-related questions that were divided into three categories: parenchymal, musculoskeletal, and vascular anatomy. After a washout period of 14 days, assessments were crossed over to the respective second reconstruction technique. The mean interperiod differences for the time to answer differed significantly between the CR–CT sequence (−204.21 ± 156.0 seconds) and the CT–CR sequence (243.33 ± 113.83 seconds; P < 0.001). Overall time reduction by CR was 65.56%. Cinematic Rendering visualization of musculoskeletal and vascular anatomy was higher rated compared to CT visualization (P < 0.001 and P = 0.003), whereas CT visualization of parenchymal anatomy received a higher scoring than CR visualization (P < 0.001). No carryover effects were observed. A questionnaire revealed that students consider CR to be beneficial for medical education. These results suggest that CR has a potential to enhance knowledge acquisition and transfer from medical imaging data in medical education.