对信息化教学设计的几点思考

信息化教学设计是伴随着信息技术在教学领域中的广泛应用而发展起来的一种新型的教学设计.本文着重对信息化教学设计的概念、策略和实践研究作一分析.     

新升格高职院校教育转型的基本路径

自中专升格的高职院校属于我国高职教育发展阵营中"三改一补"的"补"字类型,对于办学而言,其优势是深厚的办学积淀,其不足是根深蒂固的观念和行为惯性.文章提出,实现观念、管理、环境、水平、行为、模式等六大变革是新升格高职院校转型的基本路径.     

关于新建高职院校办学特色的思考

在高等教育走向大众化的今天,高职教育进入由外延型转向内涵型的重要战略转折期,新建高职院校将面临严峻的挑战.文章就新建高职院校如何尽快提高自身的办学质量和办学水平,创建自己的办学特色,在激烈竞争的教育市场中求得生存并不断发展等问题进行了分析与思考.     

机械结构对两轮移动足球机器人运动精度影响研究

以自行设计的两轮移动足球机器人的机械结构为对象,从理想情况和实际情况分别进行机器人小车的运动学分析与建模,进行比较并得出结论。分析了驱动轮半径对运动学模型的影响。最后从机械结构的设计上讨论了对小车运动精度的影响,并提出相关改进措施。     

三维散乱点的八叉树建模及程序实现

本文根据三维采样点的离散数据,用八叉树方法和与距离成反比加权法的数据插值方法重构地质体的三维模型,详细地论述了八叉树构模的程序算法,同时开发出基于VC 八叉树构模类,并嵌入电磁资料处理系统软件,为电磁资料处理的三维可视化提供了便利。     

基于空间的合理排课算法分析

针对人类学习的生理特点,从满足学生需要循序渐进地掌握知识和教师需要授课时间相对集中的需求上,分析了如何使课程表安排得更加合理,在课表空间分布角度上提出课时节次、工作日合理布局的解决方案,并依此提供了一个自动排课算法的流程图。     

一体化地籍空间数据库建设的关键问题研究

由于城乡土地建设的发展需要,建立一个能够统一分类、统一调查、统一统计的城乡一体化信息系统便成为了当务之急。本文从建立城乡一体化地籍空间数据库的几个关键问题展开论述,分析了城乡一体化地籍的管理模式,提出了采用SDE来实现空间信息和非空间信息的统一管理,研究了新旧地类的转换和转换方法。     

论如何提高教学质量来提升高校的竞争力

今天中国的高等教育已进入大众化阶段,在此阶段高等学校如何提升竞争力、提高教学质量是提升高等学校竞争力的重要途径。对如何通过提高教学质量来提升高等学校的竞争力,笔者从教学质量观、教学管理制度、师资队伍建设、教学改革、课程建设和教学质量监控等方面提出了具体措施。     

Sequence- and structure-selective mRNA m5C methylation by NSUN6 in animals

mRNA m⁵C, which has recently been implicated in the regulation of mRNA mobility, metabolism and translation, plays important regulatory roles in various biological events. Two types of m⁵C sites are found in mRNAs. Type I m⁵C sites, which contain a downstream G-rich triplet motif and are computationally predicted to be located at the 5^′ end of putative hairpin structures, are methylated by NSUN2. Type II m⁵C sites contain a downstream UCCA motif and are computationally predicted to be located in the loops of putative hairpin structures. However, their biogenesis remains unknown. Here we identified NSUN6, a methyltransferase that is known to methylate C72 of tRNA^Thr and tRNA^Cys, as an mRNA methyltransferase that targets Type II m⁵C sites. Combining the RNA secondary structure prediction, miCLIP, and results from a high-throughput mutagenesis analysis, we determined the RNA sequence and structural features governing the specificity of NSUN6-mediated mRNA methylation. Integrating these features into an NSUN6-RNA structural model, we identified an NSUN6 variant that largely loses tRNA methylation but retains mRNA methylation ability. Finally, we revealed a weak negative correlation between m⁵C methylation and translation efficiency. Our findings uncover that mRNA m⁵C is tightly controlled by an elaborate two-enzyme system, and the protein-RNA structure analysis strategy established may be applied to other RNA modification writers to distinguish the functions of different RNA substrates of a writer protein.     

ENSO and Southeast Asian biomass burning modulate subtropical trans-Pacific ozone transport

Trans-Pacific transport of enhanced ozone plumes has been mainly attributed to fossil fuel combustion in Asia in spring, but less attention has been paid to vegetation fires in Asia. Here we show that the El Niño-Southern Oscillation (ENSO)-modulated fires in Southeast Asia, rather than Asian fossil fuel plumes, dominate the interannual variability of springtime trans-Pacific transport of ozone across the entire North Pacific Ocean. During El Niño springs, the intensified fires from both the Indochinese Peninsula and Indonesia, together with large-scale circulation anomalies, result in enhanced ozone plumes that stretch over 15 000 km in both the lower-middle and upper troposphere. This enhancement is also observed in the in situ measurements of ozone concentration, with an almost 10% increase at Mauna Loa Observatory, Hawaii, a unique site to monitor the long-distance transport over the North Pacific. This study reports an unexpectedly strong influence of vegetation fires, linked with climate variability, on global tropospheric chemistry and proves once more how complex the interactions in the climate system are.