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Shuang LIANG Xue-lai WANG Ming-yang ZOU Han WANG Xue ZHOU Cai-hong SUN Wei XIA Li-jie WU Takashi X. FUJISAWA Akemi TOMODA 《Journal of Zhejiang University. Science. B》2014,(3)
研究目的:ZNF533、DOCK4和IMMP2L在大脑发育过程中起到非常重要的作用,是孤独症研究的候选基因。高加索人群的研究结果发现,ZNF533、DOCK4和IMMP2L基因的5个单核苷酸多态性(SNP)位点与孤独症高度相关。为了探讨上述位点是否与中国孤独症发生相关,我们开展了东北汉族孤独症的核心家系研究。创新要点:孤独症候选基因多态位点的研究结果通常很难得到重复。本研究首次在中国东北汉族人群中验证了与高加索人群孤独症密切相关的候选位点。这一结果对孤独症的研究具有重要指导意义。研究方法:利用SNaPshot的方法,检测了中国东北汉族370个核心家系中ZNF533(rs11885327、rs1964081)、DOCK4(rs2217262)和IMMP2L(rs12537269、rs1528039)的分布情况,利用传递不平衡检验(TDT)分析了这些多态位点与孤独症发生的相关性。重要结论:ZNF533和DOCK4基因多态性与中国北方汉族孤独症发生存在显著关联。 相似文献
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Takashi Maeda Yoshio Momouchi Hajime Sawamura 《Information processing & management》1980,16(3):119-127
A new method is described to extract significant phrases in the title and the abstract of scientific or technical documents. The method is based upon a text structure analysis and uses a relatively small dictionary. The dictionary has been constructed based on the knowledge about concepts in the field of science or technology and some lexical knowledge, for significant phrases and their component items may be used in different meanings among the fields. A text analysis approach has been applied to select significant phrases as substantial and semantic information carriers of the contents of the abstract.The results of the experiment for five sets of documents have shown that the significant phrases are effectively extracted in all cases, and the number of them for every document and the processing time is fairly satisfactory. The information representation of the document, partly using the method, is discussed with relation to the construction of the document information retrieval system. 相似文献
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青藏铁路是举世瞩目的工程,环境保护在青藏铁路施工建设中是最为关键的环节,也是一项艰巨的工作。在没有任何施工经验可以借鉴的情况下,要保证青藏铁路达到国家环保要求,做好路基边坡植被种植技术的试验是非常重要的。试验可以成为技术的基础,然而现实的施工存在诸多影响环保的因素,因此在完成实验之后,进入实际的施工,仍然需要不断的技术总结。 相似文献
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长三角大都市圈创新要素整合 总被引:1,自引:0,他引:1
被称为世界第六大都市圈的长三角地区是我国经济实力最强的地区之一,要建立长三角创新体系,内部资源配置是关键。要提高长三角的区域创新能力,必须尽快实现区域内创新要素的统一市场体系。对大都市圈创新要素构成和长三角大都市圈创新要素现状进行了分析,提出了长三角大都市圈创新要素整合模型及整合对策。 相似文献
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侨、港、台人士对图书馆建设的贡献陈福季,陈之珩(山东潍坊医学院)陈嘉庚先生1871年出生在福建省同安县集美的一个华侨世家,少年时期就离家到南洋谋生。抗日战争爆发后,陈嘉庚先生不计个人安危得失,挺身而出为国难奔走呼号,赢得了海内外同胞的尊敬。当时毛泽东... 相似文献
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Takashi Yamashita Erick B. López Jennifer R. Keene Jennifer M. Kinney 《Educational gerontology》2015,41(11):825-838
Lifelong learning is receiving greater attention due to population aging in modern societies. Lifelong learning benefits individuals by supporting their physical, psychological, social, and economic well-being. However, older adults generally have lower motivation for learning than younger adults, and facilitating long-term participation in learning activities is still challenging. Previous studies mainly identified negative factors such as barriers and obstacles to individuals’ initial participation in lifelong learning programs. As such, less is known about positive factors that promote long-term participation. To address this gap, data were collected from 330 older adults who participated in the Osher Lifelong Learning Institute program in an urban community in the United States. Results from proportional odds ordinal logistic regression analysis demonstrated that gender, number of household members, income, religious affiliation, self-rated health, and number of courses taken were associated with satisfaction with the program. In hopes to promote true lifelong learning, possible explanations about the findings are explored and several recommendations for existing lifelong learning programs are derived in this study. 相似文献
19.
Ayako Higashihara Yasuharu Nagano Takashi Ono Toru Fukubayashi 《Journal of sports sciences》2018,36(12):1313-1318
This study aimed to investigate activation characteristics of the biceps femoris long head (BFlh) and semitendinosus (ST) muscles during the acceleration and maximum-speed phases of sprinting. Lower-extremity kinematics and electromyographic (EMG) activities of the BFlh and ST muscles were examined during the acceleration sprint and maximum-speed sprint in 13 male sprinters during an overground sprinting. Differences in hamstring activation during each divided phases and in the hip and knee joint angles and torques at each time point of the sprinting gait cycle were determined between two sprints. During the early stance of the acceleration sprint, the hip extension torque was significantly greater than during the maximum-speed sprint, and the relative EMG activation of the BFlh muscle was significantly higher than that of the ST muscle. During the late stance and terminal mid-swing of maximum-speed sprint, the knee was more extended and a higher knee flexion moment was observed compared to the acceleration sprint, and the ST muscle showed higher activation than that of the BFlh. These results indicate that the functional demands of the medial and lateral hamstring muscles differ between two different sprint performances. 相似文献
20.
Takashi Umeda Kazuhiro Suzukawa Ippei Takahashi Yousuke Yamamoto Masaru Tanabe Arata Kojima 《Journal of sports sciences》2013,31(9):897-904
Abstract To clarify the physical and mental fatigue caused by intense exercise and the relationship between the two types of fatigue, we examined changes in anthropometric and biochemical variables, neutrophil function, and the Profile of Mood States (POMS) questionnaire in 13 female university judoists attending a one-week training camp. Blood glucose, total cholesterol, haemoglobin, leukocyte count, IgG, and phagocytic activity all decreased after the training camp compared with baseline (P ≤ 0.046). Aspartate aminotransferase, lactate dehydrogenase, creatine kinase, and neutrophil oxidative burst activity increased after the training camp (P ≤ 0.007). Of the POMS scores, that for Fatigue increased after the training camp (P = 0.041) and that for Vigour decreased (P = 0.042). The changes in several POMS scores correlated with the changes in blood biochemical variables. In particular, the change in Total mood disturbance was negatively associated with changes in myogenic enzymes (P ≤ 0.032). Our results suggest that intense exercise during training camps for female judoists leads to the appearance and accumulation of mental and physical fatigue, which are related to each other. 相似文献