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Tamara M. Nelson 《Medical reference services quarterly》2018,37(3):312-318
This column describes the development and implementation of a responsive library course designed to train third-year medical students as they begin their clerkships. The course design consisted of a brief face-to-face introduction during third-year orientation and an online course developed in Canvas, an online learning management system. The objective of the course was to not only introduce students to the resources but also to teach them how to effectively use those resources at the point-of-care. Students evaluated the course to assess the overall effectiveness of the instruction. Course development and content, feedback provided by students, as well as suggestions for improvement are discussed. 相似文献
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Altmetrics from Altmetric.com are widely used by publishers and researchers to give earlier evidence of attention than citation counts. This article assesses whether Altmetric.com scores are reliable early indicators of likely future impact and whether they may also reflect non-scholarly impacts. A preliminary factor analysis suggests that the main altmetric indicator of scholarly impact is Mendeley reader counts, with weaker news, informational and social network discussion/promotion dimensions in some fields. Based on a regression analysis of Altmetric.com data from November 2015 and Scopus citation counts from October 2017 for articles in 30 narrow fields, only Mendeley reader counts are consistent predictors of future citation impact. Most other Altmetric.com scores can help predict future impact in some fields. Overall, the results confirm that early Altmetric.com scores can predict later citation counts, although less well than journal impact factors, and the optimal strategy is to consider both Altmetric.com scores and journal impact factors. Altmetric.com scores can also reflect dimensions of non-scholarly impact in some fields. 相似文献
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Vandana Tiwari Jyotsna Agarwal Anumesh Kumar Pathak Shivani Singh 《Indian journal of clinical biochemistry : IJCB》2023,38(2):212
Immune dysregulation is a key feature of the coronavirus disease-2019 (COVID-19). However, disparities in responses across ethnic groups are underappreciated. This study aimed to determine the relationship between chemokines and cytokines and the severity of COVID-19. Multiplex magnetic bead-based Luminex-100 was used to assess chemokine and cytokine levels in COVID-19 patients at admission (day-1) and after 4 days. The mean age of the patients recruited was 54.3 years, with 19 (63.3%) males. COVID-19 patients had significantly lower lymphocyte, monocyte, hemoglobin and eosinophil levels than controls (p < 0.05). COVID-19 patients showed significantly higher neutrophil levels than controls (p < 0.05). The baseline levels of IL-2, IL-6, IL-8, IL-10, and IFN-α/γ significantly increased in COVID-19 patients (p < 0.05). Chemokine levels (IP-10, MCP-1, MIG, and CCL-5) were significantly in COVID-19 patients. IL-8, IP-10, and MIG levels were significantly higher in the patients with severe COVID-19 (p < 0.05). Individuals with mild COVID-19 showed significantly higher levels of INF-α, IL-2, IL-6, and IL-8, whereas IL-10 levels were significantly lower (p < 0.05). TNF-levels decreased significantly in individuals with severe COVID-19, whereas IL-6, IL-8, and MIG levels increased (p < 0.05). After 4 days, INFα-, IL-2, IL-6, IL-8, IP-10, and MIG levels were significantly higher in patients with mild disease, whereas IL-6, MIG, and TNF-αlevels were significantly higher in patients with severe disease (p < 0.05). Thus, we conclude that COVID-19 is characterized by INF-α/γ, IL-6, IL-10, IP-10, MCP-1, MIG, and CCL5 dysregulation. IL-8, MIG, and IP-10 levels distinguish between moderate and severe COVID-19. Changes in INF-α, IL-2, IL-6, IL-8, IP-10, and MIG levels can be used to monitor disease progression.Supplementary InformationThe online version contains supplementary material available at 10.1007/s12291-022-01108-x. 相似文献
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Tamara D. Afifi Walid A. Afifi Anne F. Merrill Najib Nimah 《Journal of Applied Communication Research》2016,44(4):343-361
This study examined how communal coping reveals itself in Palestinian refugee camps and the conditions that promote or prevent its occurrence. Individual and dyadic interviews were conducted with 40 mothers and one of their adolescent children living in Palestinian refugee camps in Lebanon. The results revealed that communal coping existed within the mother–adolescent dyad to a certain extent, but was rare within the larger context of the refugee camps. While families and neighbors did not typically verbalize their hardships and actively cope with them as a group, there was often an implicit recognition that they were all experiencing the same uncertainty and stress. Acting upon their uncertainty as a collective, however, was greatly hampered by mistrust within and outside the camps, due to widespread violence, privacy violations, vying for scarce resources, and disloyalty. Parents and adolescents also engaged in protective buffering whereby they attempted to reduce the stress of the family by keeping stress and fears to themselves rather than communicating about them. Even though protective buffering helped the refugees cope with chronic uncertainty and maintain a sense of normalcy, it prevented them from acting upon the problem as a group. Finally, parents emphasized that the child’s education provided hope for the future. Practical implications are discussed. 相似文献
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Objective: A natural cyclic peptide previously isolated from Citrus medica was synthesized by coupling oftetrapep-tide units Boc-Leu-Pro-Trp-Leu-Ome and Boc-Ile-Ala-Ala-Gly-Ome after proper deprotection at carboxyl and amino terminals followed by cyclization of linear octapeptide segment.Methods: Solution phase technique was adopted for the synthesis of cyclooctapeptide--sarcodactylamide.Required tetrapeptide units were prepared by coupling of Boc-protected dipeptides viz.Boc-Leu-Pro-OH and Boc-Ile-Ala-OH with respective dipeptide methyl esters Trp-Leu-Ome and Ala-Gly-Ome.Cyclization of linear octapeptide unit was done by p-nitrophenyl ester method.The structure of synthesized cyclopolypeptide was elucidated by FTIR,1H NMR,13C NMR,FABMS spectral data and elemental analysis.The newly synthesized peptide was evaluated for dif-ferent pharmacological activities including antimicrobial,anthelmintic and cytotoxic activities.Results: Synthesis of sarcodac-tylamide was accomplished with >78% yield utilizing dicyclohexylcarbodiimide (DCC) as coupling agent.Newly synthesized peptide possessed potent cytotoxic activity against Dalton's lymphoma ascites (DLA) and Ehrlich's ascites carcinoma (EAC) cell lines,in addition to moderate anthelmintic activity against earthworms Megascoplex konkanensis,Pontoscotex corethruses and Eudrilus sp.Moreover,cyclopolypeptide displayed good antimicrobial activity against pathogenic fungi Candida albicans and Gram-negative bacteria Pseudomonas aeruginosa,in comparison to standard drugs griseofulvin and ciprofloxacin.Conclusion: Solution phase technique employing DCC and triethylamine (TEA) as base proved to be effective for the synthesis of natural cyclooctapeptide.N-methyl morpholine (NMM) was found to be a better base for the cyclization of linear octapeptide unit in comparison to TEA and pyridine. 相似文献
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Pradeep Kumar 《Resonance》2017,22(4):399-405
Richard Feynman once said: “nobody understands quantum mechanics”. Still, those who devised it are perhaps the ones closest to understanding their creation. It suggests that whenever the weirdness of quantum mechanics haunts you, it is better to go back to its creators in terms of their original publications. In the present article, the author has tried to seek help from Heisenberg’s 1925 paper, in order to reduce the weirdness of going from classical observables to quantum operators. 相似文献
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Very few empirical studies have investigated programmes in which doctoral students act as peer facilitators in faculty writing groups. We report on the development of a centrally delivered doctoral student writing programme in which twenty student participants were mentored and provided with the resources to initiate their own faculty-based doctoral writing groups. ‘Legitimate peripheral participation’ was used as a conceptual lens to interpret the data collected during the establishment and evaluation of the programme. All student participants in the preparatory training course, which was developed in consultation with postgraduate students and research supervisors, went on to become doctoral writing peer facilitators of peer writing groups. Insights from seven of these showed how a well-structured and supportive programme harnessed the benefits of peer learning by bringing personal rewards to participants and building institutional capacity around doctoral research writing literacies. 相似文献