Rollback,scissor-like closure of the Mongol-Okhotsk Ocean and formation of an orocline:magmatic migration based on a large archive of age dataOA

Tracing the closure of oceans with irregular margins and the formation of an orocline are crucial for understanding plate reconstruction and continental assembly.The eastern Central Asian Orogenic Belt,where the Mongol-Okhotsk orocline is situated,is one of the world’s largest magmatic provinces.Using a large data set of U-Pb zircon ages,we updated the timing of many published igneous rocks,which allowed us to recognize tightly ’folded’ linear Carboniferous-Jurassic magmatic belts that wrap arou...     

谈高校图书馆采访工作与流通工作的协调

变革中的高校图书馆工作要求突破思维定势,馆内各部门的协调至关重要。采访部门宜经常与流通部门沟通,通过了解文献利用率变化调节文献采访,以维护读者权益,提高办馆效益。     

Effects of purposeful soccer heading on circulating small extracellular vesicle concentration and cargo

BackgroundConsidering the potential cumulative effects of repetitive head impact (HI) exposure, we need sensitive biomarkers to track short- and long-term effects. Circulating small extracellular vesicles (sEVs) (<200 nm) traffic biological molecules throughout the body and may have diagnostic value as biomarkers for disease. The purpose of this study was to identify the microRNA (miRNA) profile in circulating sEVs derived from human plasma following repetitive HI exposure.MethodsHealthy adult (aged 18–35 years) soccer players were randomly assigned to one of 3 groups: the HI group performed 10 standing headers, the leg impact group performed 10 soccer ball trapping maneuvers over 10 min, and the control group did not participate in any soccer drills. Plasma was collected before testing and 24 h afterward, and sEVs were isolated and characterized via nanoparticle tracking analysis. Next-generation sequencing was utilized to identify candidate miRNAs isolated from sEVs, and candidate microRNAs were analyzed via quantitative polymerase chain reaction. In silico target prediction was performed using TargetScan (Version 7.0; targetscan.org) and miRWalk (http://mirwalk.umm.uni-heidelberg.de/) programs, and target validation was performed using luciferase reporter vectors with a miR-7844-5p mimic in human embryonic kidney (HEK) 293T/17 cells.ResultsPlasma sEV concentration and size were not affected across time and group following repetitive HI exposure. After 24 h, the HI read count from next-generation sequencing showed a 4-fold or greater increase in miR-92b-5p, miR-423-5p, and miR-24-3p and a 3-fold or greater decrease in miR-7844-5p, miR-144-5p, miR-221-5p, and miR-22-3p. Analysis of quantitative polymerase chain reaction revealed that leg impact did not alter the candidate miRNA levels. To our knowledge, miR-7844-5p is a previously unknown miRNA. We identified 8 miR-7844-5p mRNA targets: protein phosphatase 1 regulatory inhibitor subunit 1B (PPP1R1B), LIM and senescent cell antigen-like domains 1 (LIMS1), autophagy-related 12 (ATG12), microtubule-associated protein 1 light chain 3 beta (MAP1LC3B), integrin subunit alpha-1 (ITGA1), mitogen-activated protein kinase 1 (MAPK1), glycogen synthase kinase 3β (GSK3β), and mitogen-activated protein kinase 8 (MAPK8).ConclusionCollectively, these data indicate repetitive HI exposure alters plasma sEV miRNA content, but not sEV size or number. Furthermore, for the first time we demonstrate that previously unknown miR-7844-5p targets mRNAs known to be involved in mitochondrial apoptosis, autophagy regulation, mood disorders, and neurodegenerative disease.     

基于超效率SBM模型的中国城市生态效率时空演变及影响因素

运用含有非期望产出的超效率SBM模型,研究2005-2017年中国285个地级以上城市生态效率的时空演变格局,并运用面板回归模型探析城市生态效率的影响因素.结果 表明:1)2005-2017年全国城市平均生态效率波动起伏较小,生态效率整体处于上升状态.2)尽管城市间生态效率的差异呈缩小态势,但全国地区间差异仍然较明显,...     

体裁、社会效应与学术竞争力——图书情报学科高被引论文内容结构考察

[目的/意义]学术竞争力被普遍认为是衡量学科可持续发展的关键要素;通过图书情报学(简称"图情")高被引论文的内容结构特征阐释图情学术竞争力不足的影响因素并揭示其成因。[方法/过程]融合社会分层理论、市场效率理论和资源基础理论提出学术竞争力模型,构建"体裁-学术规范-社会效应"内容分析框架,利用中国知网全文数据库图情重点期刊2009-2013年80篇高被引论文、6552条引文开展内容分析。[结果/结论]高被引论文之报导型、基础型、应用型和综述型的体裁分布依次为78.8%、3.75%、10%和7.5%,且报导型以图书馆职业研究为主;高被引论文职业实践效应明显,基础社会效应相对不足。上述发现表明,图情学科学术竞争力不足跟论文的体裁结构和社会效应水平紧密相关,职业化是导致学术竞争力不足的根源。因此,就教育层面而言,推进学科转型是一条必由之路。     

我国CI学位教育人才培养发展方向探寻——基于竞争情报研究方向（硕士点）的统计分析

立足于我国竞争情报学位教育的背景,在统计我国高等教育机构竞争情报研究方向（硕士点）的基础上,从机构数量、培养目标、设程设置、教学方式、职业资格认证几方面综合分析了我国CI人才培养的热点问题,最后提出了我国CI人才培养发展方向的几点思考。