Unusually difficult clinical presentation of an infant suffering from congenital cytomegalovirus (CMV) infection combined with alpha 1-antitrypsin (A1AT) deficiency

Congenital Cytomegalovirus (CMV) infection and alpha 1-antitrypsin (A1AT) deficiency are separately well described entities, but their simultaneous occurrence can pose a special challenge to a clinician, especially dealing with optimal diagnostic as well as therapeutic approach. Congenital CMV infection is the most common vertically transmitted infection in developed countries. In 85–95% of newborns it runs asymptomatic, while in others it is presented with jaundice, petechias, hepatosplenomegaly and central nervous system damage. A1AT deficiency is on the other hand, the most common genetic liver disease in children, and the clinical spectrum varies from the accidentally detected increased levels of transaminases through to the severe infant cholestasis that can progress to cirrhosis. The following case report describes a two-month old male with severe clinical presentation of congenital CMV infection probably exacerbated due to A1AT deficiency comorbidity. The clinical manifestations and unusually difficult clinical signs this infant presented lead to assumption that the additional liver damage exists. Extensive laboratory analyses were performed, including PCR for CMV DNA, A1AT serum concentration, A1AT genotyping, followed and confirmed with phenotyping. Patient was treated parenteral with ganciclovir, what continued with oral valganciclovir and supportive therapy. Intensive and thorough supportive treatment of the infant resulted in satisfactory progress and excellent outcome. Patient was followed-up till the age of 18 months. The presented case provides excellent example about successful overcoming obstacles in differential diagnosis of A1AT in neonates and infants. Medical charts analysis was the methodology used in making this report.     

微博平台企业监管的动态关系研究

随着互联网的普及,微博应用得以在国内高速发展,越来越多的网民开始使用微博,微博的普及率和用户的黏性也逐渐加大,更多的商家从微博应用中嗅得了商机,微博中的草根大号已经成为企业获得盈利的工具,但是各搭建平台的微博平台企业成立至今却仍却颗粒无收,种种矛盾日趋明显。本文针对中国微博发展速度过快,用户增长迅速,容易滋生用户监管方面的问题进行了分析。在研究中对微博平台企业、监管部门、用户三方之间的关系进行了研究分析,在三方的演化博弈模拟中分析了各方应对各种策略时的抉择情况。     

《体育法》实施背景下我国体育教师队伍高质量建设的机遇与挑战

运用文献资料、逻辑分析等研究方法,对《体育法》实施背景下我国体育教师队伍高质量建设开展了相关研究。研究认为:《体育法》实施背景下,我国体育教师队伍高质量建设迎来了发展机遇:体育教师权益将得到较为完善的保障;体育教师队伍将逐步“配齐配强”;体育教师职业认同将迈入新阶段;体育教师专业发展的指向性将更强。同时,也面临着诸多挑战:引进高质量专兼职体育教师的渠道亟需打通与拓宽;职前培养、职后培训对提升体育教师专业素养的功能应与时俱进;体育教师对优秀体育文化的吸收与传承能力有待加强;体育教师的综合育人能力有待进一步提升。为了更好地把握机遇,迎接挑战,研究提出了《体育法》实施背景下我国体育教师队伍高质量建设的举措:深刻领会相关条文内涵,思践并进引领高质量发展;制订优秀退役运动员、教练员进校园担任体育教师制度;树立正确的体育文化观,增强体育教师的传统体育文化素养;全面提升体育教师的综合育人能力。     

创业者控制错觉对新创企业商业模式创新的影响研究

商业模式创新对新创企业十分重要，从认知视角出发能更好地从源头解释商业模式创新的产生。基于商业模式创新认知视角和行为决策理论，构建了一个被调节的中介模型来探究创业者控制错觉对新创企业商业模式创新的影响以及该影响的中介机制和边界条件。通过对373位创业者及其所在新创企业的调研数据进行实证分析，结果显示：创业者的控制错觉对新创企业商业模式创新有积极影响；机会识别和机会评估在控制错觉和商业模式创新的关系中起到中介作用；创业者行业内联系削弱了控制错觉和机会识别的正向关系，但是增强了控制错觉和机会评估的正向关系，而行业外联系增强了控制错觉和机会识别的正向关系，但是削弱了控制错觉和机会评估的正向关系。此外，行业内联系和行业外联系对于机会识别和机会评估中介作用的发挥也具有调节作用。研究结论丰富了商业模式创新的认知视角研究，并为新创企业如何使用控制错觉来实施商业模式创新提供了有益启示。