Dynamic resistance exercise increases skeletal muscle-derived FSTL1 inducing cardiac angiogenesis via DIP2A–Smad2/3 in rats following myocardial infarction

PurposeThe aim of this study was to investigate the potential of dynamic resistance exercise to generate skeletal muscle-derived follistatin like-1 (FSTL1), which may induce cardioprotection in rats following myocardial infarction (MI) by inducing angiogenesis.MethodsMale, adult Sprague-Dawley rats were randomly divided into 5 groups (n = 12 in each group): sham group (S), sedentary MI group (MI), MI + resistance exercise group (MR), MI + adeno-associated virus (AAV)–FSTL1 injection group (MA), and MI + AAV–FSTL1 injection + resistance exercise group (MAR). The AAV–FSTL1 vector was prepared by molecular biology methods and injected into the anterior tibialis muscle. The MI model was established by ligation of the left anterior descending coronary artery. Rats in the MR and MAR groups underwent 4 weeks of dynamic resistance exercise training using a weighted climbing-up ladder. Heart function was evaluated by hemodynamic measures. Collagen volume fraction of myocardium was observed and analyzed by Masson''s staining. Human umbilical vein vessel endothelial cells culture and recombinant human FSTL1 protein or transforming growth factor-β receptor 1 (TGFβR1) inhibitor treatment were used to elucidate the molecular signaling mechanism of FSTL1. Angiogenesis, cell proliferation, and disco interacting protein 2 homolog A (DIP2A) location were observed by immunofluorescence staining. The expression of FSTL1, DIP2A, and the activation of signaling pathways were detected by Western blotting. Angiogenesis of endothelial cells was observed by tubule experiment. One-way analysis of variance and Student''s t test were used for statistical analysis.ResultsResistance exercise stimulated the secretion of skeletal muscle FSTL1, which promoted myocardial angiogenesis, inhibited pathological remodeling, and protected cardiac function in MI rats. Exercise facilitated skeletal muscle FSTL1 to play a role in protecting the heart. Exogenous FSTL1 promoted the human umbilical vein vessel endothelial cells proliferation and up-regulated the expression of DIP2A, while TGFβR1 inhibitor intervention down-regulated the phosphorylation level of Smad2/3 and the expression of vascular endothelial growth factor-A, which was not conducive to angiogenesis. FSTL1 bound to the receptor, DIP2A, to regulate angiogenesis mainly through the Smad2/3 signaling pathway. FSTL1–DIP2A directly activated Smad2/3 and was not affected by TGFβR1.ConclusionDynamic resistance exercise stimulates the expression of skeletal muscle-derived FSTL1, which could supplement the insufficiency of cardiac FSTL1 and promote cardiac rehabilitation through the DIP2A–Smad2/3 signaling pathway in MI rats.     

浅析教师招聘工作的流程

本文以自己在招聘工作中的经验,从招聘专业需求分析、招聘信息的发布、招聘组织和考核、办理录 用手续等方面,探讨了我院教师招聘工作的流程。     

采用ISP器件的数字系统实验板

介绍了在系统编程实验板的具体结构.该实验装置既可完成大量基础性数字逻辑实验和数字系统设计,又可用于第二课堂.为学生学习ISP技术提供了一个方便的实验设备.     

IRM研究的力作-评《信息资源管理导论》

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Co13O8—metalloxocubes: a new class of perovskite-like neutral clusters with cubic aromaticity

Exploring stable clusters to understand structural evolution from atoms to macroscopic matter and to construct new materials is interesting yet challenging in chemistry. Utilizing our newly developed deep-ultraviolet laser ionization mass spectrometry technique, here we observe the reactions of neutral cobalt clusters with oxygen and find a very stable cluster species of Co₁₃O₈ that dominates the mass distribution in the presence of a large flow rate of oxygen gas. The results of global-minimum structural search reveal a unique cubic structure and distinctive stability of the neutral Co₁₃O₈ cluster that forms a new class of metal oxides that we named as ‘metalloxocubes’. Thermodynamics and kinetics calculations illustrate the structural evolution from icosahedral Co₁₃ to the metalloxocube Co₁₃O₈ with decreased energy, enhanced stability and aromaticity. This class of neutral oxygen-passivated metal clusters may be an ideal candidate for genetic materials because of the cubic nature of the building blocks and the stability due to cubic aromaticity.     

IREG排名审核：大学排名质量评估的新方式

采用比较研究的方法,对IREG 协会的排名审核标准、评估方法、审核流程进行了系统介绍。鉴于中国大学综合实力排名的排名方法规范性与柏林原则的要求差距明显,且具有个体差异性,因此,建议中国大学排名机构对照《IREG 排名审核手册》开展自我审核;有条件的可向IREG协会申请排名审核。中国高等教育研究学术组织应着手研制基于中国国情的大学排名审核标准、评估方法和工作流程,开展大学排名的审核工作,构建起中国大学排名的外部质量保障机制。     

深化新时代教育评价改革，探析高校教师发展路径

评价具有指挥棒作用,中共中央、国务院颁发的《深化新时代教育评价改革总体方案》对于根治教育评价“唯分数、唯升学、唯文凭、唯论文、唯帽子”的顽瘴痼疾具有重要导向作用。通过调研和比较“985”“211”高校及其他高校教师发展现状及差异,分析两类高校教师发展的各个环节的差异,从而探究高校教师教学发展现状及其影响因素,为合理制定教师评价提供参考依据。     

教师“评价认同”：评价促进教师发展的 内生力

教师“评价认同”,是教师对施加于自身的以“人”属性及价值实现为目的的“本源性”教师评价所产生的心理认可和赞同,以及对以多元化评价目标、主体、内容及形式为具体表现的“多维性”教师评价产生的认可与赞同。它通过教师对评价觉知、审视与思悟的过程表现为一种促进教师“全面、和谐、持续”发展的源于内部的“内生力”。教师评价通过“评价认同”促进教师发展,体现着“内生力”的实现。     

中国特色社会主义理论体系与社会主义核心价值体系辨微

作为马克思主义中国化的理论成果,"中国特色社会主义理论体系"与"社会主义核心价值体系"在基本内涵、逻辑结构、地位等方面具有明显区别,但在内容、性质、功能、特征等方面又具有内在联系。对它们的辩证关系进行学理分析,具有重大而深远的意义。     

中国湿地保护修复成效及发展策略

湿地具有多种生态服务功能,其保护和恢复事关国家生态安全、经济社会可持续发展和生存福祉。文章系统总结了我国湿地资源现状、湿地保护工作取得的成效,以期支撑湿地生态系统保护与管理决策。遥感监测结果显示,2020年中国湿地面积约为41.2×104 km2,位居亚洲第一。党的十八大以来,我国湿地面积整体呈恢复态势,保障水安全的作用更加明显,湿地生物多样性保护成效显著,湿地碳汇功能潜力巨大,湿地合理利用模式不断创新,保护体系日趋完善,恢复技术体系基本形成。为推进新时期湿地保护工作发展,建议实施面向国家重大需求的湿地保护战略行动,完善湿地科学基础理论和学科体系,创新完善湿地保护修复技术和工程措施,加强建设湿地研究人才高地和湿地管理咨询智库。