Predecessors of preprint servers

Although there was an early experiment in the 1960s with the central distribution of paper preprints in the biomedical sciences, these sciences have not been early adopters of electronic preprint servers. Some barriers to the development of a ‘preprint culture’ in the biomedical sciences are described. Multiple factors that, from the 1960s, fostered the transition from a paper-based preprint culture in high energy physics to an electronic one are also described. A new revolution in scientific publishing, in which journals come to be regarded as an overlay on electronic preprint databases, will probably overtake some areas of research much more quickly than others.     

Incidence and characteristics of injury in under-19 academy level rugby league match play: A single season prospective cohort study

Academy rugby league competition is an important step along the pathway to professional status, but little is known about injury at this level of the game. The aim of this research was to establish the nature, incidence and burden of injury in English academy rugby league. Using an observational prospective cohort study design, and a time-loss injury definition, the injury outcomes of three professional rugby league academies were recorded during the 2017 season. A total of 87 injuries occurred in 59 matches for an overall injury incidence of 85 (95%CI 67–103) injuries per 1000 hours played. The mean severity of injury was 22 ± 19 days resulting in an overall injury burden of 1898 (95%CI 1813–1983) days lost per 1000 hours. The tackle event was the most common cause of injury (77% of all injuries). Forwards sustained a greater proportion of injuries than backs (forwards 67% vs. backs 33% of injuries). Concussion (13 (6–20) per 1000 hours) and ankle sprains (11 (4–17) per 1000 hours) were the most commonly diagnosed injuries. The shoulder joint was the most commonly injured site (17 (9–25) per 1000 hours). The incidence of injury for academy rugby league is similar to senior professional rugby league.     

Microfluidic system for near-patient extraction and detection of miR-122 microRNA biomarker for drug-induced liver injury diagnostics

Drug-induced liver injury (DILI) results in over 100 000 hospital attendances per year in the UK alone and is a leading cause for the post-marketing withdrawal of new drugs, leading to significant financial losses. MicroRNA-122 (miR-122) has been proposed as a sensitive DILI marker although no commercial applications are available yet. Extracellular blood microRNAs (miRNAs) are promising clinical biomarkers but their measurement at point of care remains time-consuming, technically challenging, and expensive. For circulating miRNA to have an impact on healthcare, a key challenge to overcome is the development of rapid and reliable low-cost sample preparation. There is an acknowledged issue with miRNA stability in the presence of hemolysis and platelet activation, and no solution has been demonstrated for fast and robust extraction at the site of blood draw. Here, we report a novel microfluidic platform for the extraction of circulating miR-122 from blood enabled by a vertical approach and gravity-based bubble mixing. The performance of this disposable cartridge was verified by standard quantitative polymerase chain reaction analysis on extracted miR-122. The cartridge performed equivalently or better than standard bench extraction kits. The extraction cartridge was combined with electrochemical impedance spectroscopy to detect miR-122 as an initial proof-of-concept toward an application in point-of-care detection. This platform enables the standardization of sample preparation and the detection of miRNAs at the point of blood draw and in resource limited settings and could aid the introduction of miRNA-based assays into routine clinical practice.     

Peak movement and collision demands of professional rugby league competition

ABSTRACT

To quantify the peak movement and contact demands of National Rugby League (NRL) and European Super League (ESL) competition players were tracked during 10 NRL (166 files) and 10 ESL (143 files) matches using microtechnology devices. The peak 1- to 5-min periods were then calculated for average match speed (m·min^?1), and acceleration (m·s^?2) when 0, 1, 2, and ≥3 collisions per min occurred. Linear mixed effect models and Cohen’s effect size statistic (± 90%CI) were used to determine the differences in movement profiles when collisions occurred. Compared to no collision periods, as frequency of collisions per minute increased, there were progressive reductions in running speed for most positional groups. The addition of 1 or more collisions per min resulted in average effect size reductions in match speed of ?0.14 for NRL forwards, ?0.89 for NRL backs, ?0.48 for ESL forwards, and ?2.41 for ESL backs. ESL forwards had the highest frequency of peak periods involving 3 or more collisions per min, 22% of all periods, followed by NRL forwards (14%), NRL backs (10%) and ESL backs (8%). This study highlights the peak movement and collision demands of professional rugby league competition and allows practitioners to develop training drills that reflect worst case scenarios.     

Six-year body composition change in male elite senior rugby league players

This study investigated the change in body composition and bone mineral content (BMC) of senior rugby league (RL) players between 2008 and 2014. Twelve male professional RL players (age, 24.6 ± 4.0 years; stature, 183.4 ± 8.4 cm) received a dual-energy X-ray absorptiometry scan during preseason in 2008 and 2014. Between 2008 and 2014, very likely increases in leg lean mass (LM), total trunk and leg BMC, and a likely increase in arm BMC and possible increases in body mass (BM), total and trunk fat mass (FM), and total, trunk and arm LM were observed. Unlikely decreases and unclear changes in leg and arm FM were also found. Large negative correlations were observed between age and BM (r = ?0.72), LM (r = ?0.70), FM (r = ?0.61) and BMC (r = ?0.84) change. Three participants (19.1 ± 1.6 years) increased LM by 7.0–9.3 kg. Younger players had the largest increases in LM during this period, although an older player (30-year old) still increased LM. Differences in body composition change were also observed for participants of the same age, thus contextual factors should be considered. This study demonstrates the individuality of body composition changes in senior professional rugby players, while considering the potential change in young athletes.     

Psychosocial outcomes associated with soccer academy involvement: Longitudinal comparisons against aged matched school pupils

ABSTRACT

Despite literature highlighting numerous risks to the healthy psychosocial development of youth elite academy soccer players, little of this research is based on high-quality research designs. This study employed a prospective longitudinal cohort design to track psychosocial outcomes of academy involvement within male youth elite soccer players (n = 33, U12-U16 age groups) compared to age-matched soccer-active school pupils (n = 44) over 12 months. Participants completed questionnaires assessing the most commonly raised psychosocial concerns at four equally spaced data collection periods (T1–T4). Repeated measures multivariate analysis of variance (MANOVAs) indicated that, over the year, both groups reported a healthy and improving stress and recovery balance, as well as positive and stable needs satisfaction and physical, psychological and social well-being. Academy players reported stable positive school-related quality of life, whereas school pupils reported increases from T3 to T4. Academy players reported consistent significantly higher total athletic identity and exclusivity of identity. Findings suggest that many concerns around negative psychosocial impacts of soccer academy involvement did not materialise in this context. However, heightened athletic identities remained a concern.