Characteristics and publication patterns of theses from a Peruvian medical school

Background: Many medical schools require a student thesis before graduation. Publishing results in a peer‐reviewed journal could be an indicator of scientific value and acceptability by the scientific community. The publication pattern of theses published by medical students in Peru is unknown. The aim of this study was to assess the characteristics and publication pattern of theses in biomedical‐indexed journals conducted by medical students in a university with the highest research output in Peru. Methods: Data from registered theses between 2000 and 2003 were obtained from the university library. Publication of theses in biomedical journals was assessed in 2008 by a search strategy using PubMed, Google Scholar, LILACS, LIPECS and SciELO. Results: Four hundred and eighty‐two medical theses were registered between 2000 and 2003; 85 (17.6%) were published in biomedical‐indexed journals. Of the published theses, 28 (5.8%) were published in MEDLINE‐indexed journals, 55 (11.4%) in SciELO‐indexed journals, 61 (12.6%) in LILACS‐indexed journals and 68 (14.1%) in LIPECS‐indexed journals. Most of the published theses (80%) were in Spanish and published in Peruvian journals; and 17 theses (20%) were published in foreign journals (all of them indexed in MEDLINE). In addition, 37 (43.5%) belong primarily to internal medicine, and 24 (28.2%) belong primarily to infectious diseases. Medical students were first authors in 71 (83.5%) of the articles. Conclusion: In this study, most of the published theses were in Spanish, published in local journals and indexed in LIPECS. The percentage of published theses in biomedical journals at this university is comparable with others coming from developed countries.     

Use of specific IgE to fractions of gynandropsis gynandra pollen inin vitro diagnostic test

The study was aimed at presence of specific IgE antibody levelsinvitro to the identified antigen. Based on positive skin test with Gynandropsis gynandra and elevated levels of total IgE (>325 IU/ml) 104 patients were selected. Healthy, asymptomatic individuals (25) with low total IgE (<325 IU/ml) were included as controls. The mean OD values by ELISA for specific IgE were 0.67±0.21, 0.57±0.18 and 0.56±0.18 with whole pollen antigen, 46-37 kD fraction and 36-32 kD fraction, respectively. The specificity and sensitivity between skin test positivity with whole pollen antigen verses fraction with mol.wt 46-37 kD was 90% and 90% and for fraction with mol.wt 36-32 kD was found to be 81.1% and 89.4%. The clusters with molecular weights 46-37 kD and 36-32 kD may be useful inin vitro diagnostic test. Fractions within these clusters need to be identified for a higher specificity.     

Development of a validated search filter for Ovid Embase for degenerative cervical myelopathy

Background

Degenerative cervical myelopathy (DCM) is a recently proposed umbrella term for symptomatic cervical spinal cord compression secondary to degeneration of the spine. Currently literature searching for DCM is challenged by the inconsistent uptake of the term ‘DCM’ with many overlapping keywords and numerous synonyms.

Objectives

Here, we adapt our previous Ovid medline search filter for the Ovid embase database, to support comprehensive literature searching. Both embase and medline are recommended as a minimum for systematic reviews.

Methods

References contained within embase identified in our prior study formed a ‘development gold standard’ reference database (N = 220). The search filter was adapted for embase and checked against the reference database. The filter was then validated against the ‘validation gold standard’.

Results

A direct translation was not possible, as medline indexing for DCM and the keywords search field were not available in embase . We also used the ‘focus’ function to improve precision. The resulting search filter has 100% sensitivity in testing.

Discussion and Conclusion

We have developed a validated search filter capable of retrieving DCM references in embase with high sensitivity. In the absence of consistent terminology and indexing, this will support more efficient and robust evidence synthesis in the field.     

Keeping Users at the Center: Developing a Multimedia Interface for Informed Consent

Viewing “informing” as a process to protect patients and support autonomy, we undertook a user-centered design process to develop online support for informed consent in pediatric Phase I research trials. Challenges included (a) delivering accurate information to people unfamiliar with medical terminology; (b) delivering this information humanely under time constraints and heightened emotions; (c) allowing users control over the information, while ensuring availability of legally required information. We addressed these challenges through analyses of audience, task, and information design.     

Enhancement of myeloperoxidase activity in WBCS in oral cancer patients treated with Granulocyte Macrophage Colony Stimulating Factor (GM-CSF)—A pilot study

In a pilot study with five oral cancer patients undergoing radiotherapy (RT) three were given Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) as a protective agent to reduce the mucosal inflammation during radiotherapy. The myeloperoxidase (MPO) enzyme activity in WBC was quantitated. The three patients showed a significant increase in the MPO activity when compared with two untreated controls indicating the efficacy of GM-CSF as a protective agent. It is suggested that further detailed studies with larger number of patients would be useful.     

Analysis of Parent,Teacher, and Consultant Speech Exchanges and Educational Outcomes of Students With Autism During COMPASS Consultation

The significant increase in the numbers of students with autism combined with the need for better trained teachers (National Research Council, 2001) call for research on the effectiveness of alternative methods, such as consultation, that have the potential to improve service delivery. Data from 2 randomized controlled single-blind trials indicate that an autism-specific consultation planning framework known as the collaborative model for promoting competence and success (COMPASS) is effective in increasing child Individual Education Programs (IEP) outcomes (Ruble, Dalrymple, & McGrew, 2010 Ruble, L. A., Dalrymple, N. J. and McGrew, J. H. 2010. The effects of consultation on Individualized Education Program outcomes for young children with autism: The collaborative model for promoting competence and success. Journal of Early Intervention, 32: 286–301. doi:10.1177/1053815110382973[Crossref], [PubMed] , [Google Scholar]; Ruble, McGrew, & Toland, 2011 Ruble, L., McGrew, J. and Toland, M. Randomized controlled study of teacher training in autism. Poster session presented at the meeting of the American Psychological Association. Washington, DC. August.  [Google Scholar]). In this study, we describe the verbal interactions, defined as speech acts and speech act exchanges that take place during COMPASS consultation, and examine the associations between speech exchanges and child outcomes. We applied the Psychosocial Processes Coding Scheme (Leaper, 1991 Leaper, C. 1991. Influence and involvement in children's discourse: Age, gender, and partner effects. Child Development, 62: 797–811. doi:10.1111/j.1467-8624.1991.tb01570.x[Crossref], [PubMed], [Web of Science ®] , [Google Scholar]) to code speech acts. Speech act exchanges were overwhelmingly affiliative, failed to show statistically significant relationships with child IEP outcomes and teacher adherence, but did correlate positively with IEP quality.     

THE EVALUATION SYSTEM AT THE MEDICAL SCHOOL OF MAASTRICHT

The extensive scheme for both formative and summative assessment of medical students established at a new new medical school is described and discussed. The establishment of multi‐disciplinary project groups and the involvement of educationalists and psychometricians are unique features of the project. The wide range of testing procedures, including self‐assessment units, indicate the complexity of an evaluation program which attempts to cover ALL the competency domains relevant to medicine. The revelation of the incongruence of the program with the educational philosophy of the school shows the necessity for involvement of “consumers” in such programs.