Dielectrophoretic differentiation of mouse ovarian surface epithelial cells, macrophages, and fibroblasts using contactless dielectrophoresis

Ovarian cancer is the leading cause of death from gynecological malignancies in women. The primary challenge is the detection of the cancer at an early stage, since this drastically increases the survival rate. In this study we investigated the dielectrophoretic responses of progressive stages of mouse ovarian surface epithelial (MOSE) cells, as well as mouse fibroblast and macrophage cell lines, utilizing contactless dielectrophoresis (cDEP). cDEP is a relatively new cell manipulation technique that has addressed some of the challenges of conventional dielectrophoretic methods. To evaluate our microfluidic device performance, we computationally studied the effects of altering various geometrical parameters, such as the size and arrangement of insulating structures, on dielectrophoretic and drag forces. We found that the trapping voltage of MOSE cells increases as the cells progress from a non-tumorigenic, benign cell to a tumorigenic, malignant phenotype. Additionally, all MOSE cells display unique behavior compared to fibroblasts and macrophages, representing normal and inflammatory cells found in the peritoneal fluid. Based on these findings, we predict that cDEP can be utilized for isolation of ovarian cancer cells from peritoneal fluid as an early cancer detection tool.     

An empirical investigation of factors influencing the adoption of data mining tools

Previous studies explored the adoption of various information technologies. However, there is little empirical research on factors influencing the adoption of data mining tools (DMTs), particularly at an individual level. This study investigates how users perceive and adopt DMTs to broaden practical knowledge for the business intelligence community. First, this study develops a theoretical model based on the Technology Acceptance Model 3, and then examines its perceived usefulness, perceived ease of use, and its ability to explain users’ intentions to use DMTs. The model's determinants include 4 categories: the task-oriented dimension (job relevance, output quality, result demonstrability, response time, and format), control beliefs (computer self-efficacy and perceptions of external control), emotion (computer anxiety), and intrinsic motivation (computer playfulness). This study also surveys the moderating effect of experience and output quality on the determinants of DMT adoption and use. An empirical study involving 206 DMT users was conducted to evaluate the model using structural equation modeling. Results demonstrate that the proposed model explains 58% of the variance. The findings of this study have interesting implications with respect to DMT adoption, both for researchers and practitioners.     

Developing and sustaining a sense of place: The role of social information

This exploration of the role of information in helping people to develop and sustain feelings of belonging, or a sense of place, is based on a study that investigated the reasons for the high population turnover in the Northern Territory of Australia. The Northern Territory along with Darwin, its capital, has a number of unusual characteristics including geographical isolation. A key component of the theoretical framework for the research focuses on social information, which has similarities to the more commonly termed everyday life information. The specific concern is with the kind of information that helps people connect to a community and is clearly linked with social networking. The sample for the major empirical component for the article was recruited at Darwin's Mindil Beach Market. In telephone phone interviews with those who had agreed to participate, participants discussed how they learned about Darwin and the Northern Territory, and their views of Darwin as a place to live. Interpersonal contacts, including at the Market and at special events, were most often mentioned in relation to information, confirming literature findings on the importance of family and friends as an information source. Other sources were newspapers and physical markers around the City of Darwin. The conclusion is that the processes of social networking, which work well for some residents, could be enhanced through the use of information grounds, a concept widely discussed in the library and information science literature. Obvious information grounds in Darwin, where the usual processes could be enhanced by the distribution of information by formal information providers, include Mindil Beach Market and the special events for which Darwin is renowned.     

Academic Development as Academic Work

In this paper the authors reflect on their experiences of being academic developers and suggest how our profession might advance in the future. Our inquiry focuses on academic development and how we can support our clients more effectively. We propose that the profession of academic development should aim for academic status with many more research‐active staff contributing to its knowledge base. If this profession were located within the already recognized research field of higher education, we believe a number of potential benefits could accrue. These include a new level of professional standing, greater efficiency in our universities and a more substantial academic development community. Our thoughts and arguments on the nature of our work are framed within a discussion of professional identity, knowledge and academic freedom.     

Out of the ordinary: recapturing the liberal traditions of a university education through field courses

This article aims to stimulate debate about the nature of field courses in higher education. We use a colloquium format that allows each of us to reflect on the philosophy of field course teaching and our writing endeavours to establish a dialogue between the authors and leave the reader with a sense of curiosity. It starts with a position paper that sets out a particular viewpoint on field courses to which responses were invited. Two of the respondents were experienced field-course teachers in disciplines traditionally associated with this type of curriculum, the other a lecturer in a non-field-course-oriented discipline.     

Higher education curriculum orientations and the implications for institutional curriculum change

This research is based on an empirical study exploring how academics make curriculum decisions and their perceptions of the influences that shape their decisions. Interviews were held with 20 academics from diverse disciplines, who were both research active and committed to teaching. The higher education curriculum was conceptualised as a field of decision-making shaped by academics’ beliefs about educational and contextual influences. The study identified five distinctive curriculum orientations representing coherent patterns of curriculum decisions aligned with academics’ beliefs about educational purposes. Case studies are presented to elucidate each of the curriculum orientations. Curriculum orientations were also found to shape academics’ responses to educational change. The following higher education change drivers are explored: graduate employability and the skills agenda, teaching–research relationships, changing understandings about teaching and learning, educational technologies and flexible delivery. The findings suggest implications for institutional curriculum change initiatives and academic development programmes.     

Sustaining technological innovation: The example of videoconferencing in English Schools

The main factors associated with technology integration have been the subject of research for over a decade. However, the conditions which sustain technological developments have been less frequently investigated. This paper explores this issue in the context of the use of videoconferencing in schools in England. The research took a multiple case-study approach by returning to schools with a reputation for demonstrating innovative policy and practice in videoconferencing, which were the subject of an earlier investigation. Analysis of developments in the interim five-year period led to the construction of a five-level typology of change. Further analysis identified critical dimensions associated with the sustainability of videoconferencing. These included technical and structural factors, as well as policy frameworks and personnel status. The perceived usefulness and relevance of videoconferencing as a learning technology emerges as a central determinant of sustainability, with the conclusion that for policymakers and schools, videoconferencing has become an ‘orphan’ technology.     

Androgyny and the Mentoring Role: an empirical study to examine for prominent mentor expectations

abstract

As part of an ongoing research design, we wished to examine how mentors behave whilst in the mentoring role. The starting point for this was a study to examine how mentors felt they were expected to behave in context; that is, an organised educational mentoring situation, as we recognised the importance of situation‐specificity. Prior to empirical study, we theorised that the mentor may be androgynous; or more precisely are able to display high levels of expressive and instrumental behaviour. Seven suppositions were examined. Our findings were that whilst in the role, mentors do indeed feel expected to blend and display high levels of both instrumentality and expressiveness. Further, the levels of expressive behaviour they perceived they were expected to display were significantly higher. The higher levels of expected expressive behaviour is not congruent with the androgyny literature: our samples proved an exception to the ‘masculine supremacy effect’. Also, that mentoring may require high levels of stereotypically feminine behaviour is something that the mass of mentoring literature has not discussed and may warrant further attention. We concluded that the diverse, complex and complicated nature of mentoring is met with expectations to display flexibility and versatility across situations — to take a proactive approach to coping with mentoring situational demands — such is not mitigated by gender. Their reported high expected levels of both expressive and instrumental behaviour are congruent with our theory of the androgynous mentor.     

Behaviour,race and inclusion

Abstract

This article argues that because of the practice in the 1960s of placing black children in so-called ‘educational subnormal’ units there is now a reluctance to look at the speci?c needs of African Caribbean children. The post-Warnock politics of integration/inclusion following this period point to the ‘institutional racism’ of schools and white teachers to explain poor exam results. This article argues that in the current political climate which prioritizes ‘inclusion’ we should not patronize the black child. There is a need to position the factors of oppression equally with other factors of underachievement; to re-employ psychological, behavioural and educational tools as well as to deconstruct school processes and teacher attitudes; and to consider psychosocial factors related to underachievement without forgetting the reality of institutional racism. The article illustrates a research project that looks at the pastoral needs of African Caribbean children. It points to these needs as the key variable in unlocking their underachievement at school.     

BROADCAST TELEVISION AS A CAUSE OF AGGRESSION? RECENT FINDINGS FROM A NATURALISTIC STUDY

This sub‐study is part of a longitudinal naturalistic investigation monitoring the social behaviour of young children (3‐8‐year‐olds) before and after the arrival of broadcast television in St Helena, South Atlantic.

Children's free‐play behaviour in first school playgrounds was videotaped in 1994 (pre‐tv), and in 1995 and 1996 (post‐tv), and then coded and analysed by trained observers. Findings showed no significant differences in children's behaviour either across the availability of broadcast television (i.e. CNN) or with the addition of further channels (CNN plus others).