Towards model governance in predictive toxicology

Efficient management of toxicity information as an enterprise asset is increasingly important for the chemical, pharmaceutical, cosmetics and food industries. Many organisations focus on better information organisation and reuse, in an attempt to reduce the costs of testing and manufacturing in the product development phase. Toxicity information is extracted not only from toxicity data but also from predictive models. Accurate and appropriately shared models can bring a number of benefits if we are able to make effective use of existing expertise. Although usage of existing models may provide high-impact insights into the relationships between chemical attributes and specific toxicological effects, they can also be a source of risk for incorrect decisions. Thus, there is a need to provide a framework for efficient model management. To address this gap, this paper introduces a concept of model governance, that is based upon data governance principles. We extend the data governance processes by adding procedures that allow the evaluation of model use and governance for enterprise purposes. The core aspect of model governance is model representation. We propose six rules that form the basis of a model representation schema, called Minimum Information About a QSAR Model Representation (MIAQMR). As a proof-of-concept of our model governance framework we develop a web application called Model and Data Farm (MADFARM), in which models are described by the MIAQMR-ML markup language.     

Effects of the amount of acquisition and contextual generalization on the renewal of instrumental behavior after extinction

Four experiments with rat subjects examined the role of context during the extinction of instrumental (free-operant) behavior. In all experiments, leverpressing was first reinforced on a variable-interval 30-s schedule and then extinguished before being tested in the extinction and renewal contexts. The results identified three important variables affecting the renewal effect after instrumental extinction. First, ABA and ABC forms of renewal were strengthened by increasing the amount of acquisition training. This suggests that the strength of the association learned during acquisition, or the final level of performance, influences the degree of renewal after extinction. The effect of the amount of training was modulated by the second factor, the degrees of generalization from the acquisition and extinction contexts to the test context. The third variable was acquisition training in multiple contexts, which was shown to strengthen ABC renewal. Methodological, theoretical, and practical implications are discussed.     

Foreword

Despite growing interest in the condition of school facilities as a dimension of school finance adequacy, reliable measures of capital stock for large samples of schools are hard to come by. In this article, we offer new methods for (a) measuring the existing capital stock of public schools, (b) defining adequacy in school facilities, and (c) measuring the cost of bringing existing school facilities up to an adequate standard. We apply our procedures to all school districts in Michigan, one of the few states that offers no state aid to local districts for the construction of capital facilities. Our estimates indicate large variations in school buildings and facilities across local communities that are highly correlated with local property wealth. Because we use publicly available data that are recently available for school districts nationwide, these methods can be readily replicated for other states.     

The effect of plot explicit,educational explicit,and implicit inference information and coviewing on children's internal and external cognitive processing

Parental coviewing – the act of being present when a child is watching television – can influence the child’s cognitive processing and emotional reactions. This study investigated the role coviewing has on the child’s cognitive processing – which is evidenced by the phasic psychophysiological orienting response to three types of information: plot explicit, educational explicit, and implicit inference. An experiment was conducted that measured the heart rate of children (N?=?88; mean age?=?9.12 years) while watching messages either with or without a parent present in the room. It was predicted, and found, that coviewing leads to greater resource allocation to encoding the message – as indicated by phasic cardiac deceleration, and that information that required internal processing, such as plot explicit or implicit inferential content, leads to greater resources allocated to internal processing – as indicated by phasic cardiac acceleration. Implications for parental mediation strategies and educational television programming are given.     

Graduate Education in Criminology or Criminal Justice: Assessing Course Requirements

Although some have claimed that criminal justice and criminology have arrived as disciplines, recent research reveals that there is little consistency amongst Master's programs. This paper replicates and extends previous research into curricular requirements. The required course curricula of United States programs offering a Master's degree in criminal justice or criminology are described. This research identifies correlates of specific course requirements and provides a discussion of the current and future state of criminal justice and criminology graduate education.     

Acute effects of static stretching on characteristics of the isokinetic angle – torque relationship,surface electromyography,and mechanomyography

Abstract

The aims of this study were to examine the acute effects of static stretching on peak torque, work, the joint angle at peak torque, acceleration time, isokinetic range of motion, mechanomyographic amplitude, and electromyographic amplitude of the rectus femoris during maximal concentric isokinetic leg extensions at 1.04 and 5.23 rad · s^?1 in men and women. Ten women (mean ± s: age 23.0 ± 2.9 years, stature 1.61 ± 0.12 m, mass 63.3 ± 9.9 kg) and eight men (age 21.4 ± 3.0 years, stature 1.83 ± 0.11 m, mass 83.1 ± 15.2 kg) performed maximal voluntary concentric isokinetic leg extensions at 1.04 and 5.23 rad · s^?1. Following the initial isokinetic tests, the dominant leg extensors were stretched using four static stretching exercises. After the stretching, the isokinetic tests were repeated. Peak torque, acceleration time, and electromyographic amplitude decreased (P≤ 0.05) from pre- to post-stretching at 1.04 and 5.23 rad · s^?1; there were no changes (P > 0.05) in work, joint angle at peak torque, isokinetic range of motion, or mechanomyographic amplitude. These findings indicate no stretching-related changes in the area under the angle – torque curve (work), but a significant decrease in peak torque, which suggests that static stretching may cause a “flattening” of the angle – torque curve that reduces peak strength but allows for greater force production at other joint angles. These findings, in conjunction with the increased limb acceleration rates (decreased acceleration time) observed in the present study, provide tentative support for the hypothesis that static stretching alters the angle – torque relationship and/or sarcomere shortening velocity.