Increased plasma zonulin in patients with sepsis

Introduction:

Zonulin is a eukaryotic protein structurally similar to Vibrio cholerae’s zonula occludens toxin. It plays an important role in the opening of small intestine tight junctions. The loss of gut wall integrity during sepsis might be pivotal and has been described in various experimental as well as human studies. Increased levels of zonulin could be demonstrated in diseases associated with increased intestinal inflammation, such as celiac disease and type 1 diabetes. We therefore investigated the role of plasma levels of zonulin in patients with sepsis as a non-invasive marker of gut wall integrity.

Materials and methods:

Plasma level of zonulin was measured in 25 patients with sepsis, severe sepsis or septic shock according to ACCP/SCCM criteria at the first day of diagnosed sepsis. 18 non-septic post-surgical ICU-patients and 20 healthy volunteers served as control. Plasma levels were determined by using commercially available ELISA kit. Data are given as median and interquartile range (IQR).

Results:

Significantly higher plasma concentration of zonulin were found in the sepsis group: 6.61 ng/mL (IQR 3.51–9.46), as compared to the to the post-surgical control group: 3.40 ng/mL (IQR 2.14–5.70) (P = 0.025), as well as to the healthy group: 3.55 ng/mL (IQR 3.14–4.14) (P = 0.008).

Conclusion:

We were able demonstrate elevated levels of plasma zonulin, a potential marker of intestinal permeability in septic patients. Increased zonulin may serve as an additional mechanism for the observed increased intestinal permeability during sepsis and SIRS.     

When do people accept cultural diversity?: Affect as determinant

Two experiments examined the influence of affect on the acceptance of cultural diversity. In Experiment 1, the salience of affective reactions towards Turkish immigrants was manipulated by asking German participants to think about their negative feelings towards Turks in general or towards a subgroup of Turks. It was found that the salience of negative affective reactions led to a decreased acceptance when affective reactions were generalized to the whole group, but not when they were attributed to a subgroup. Experiment 2 investigated the moderating role of perceived homogeneity with regards to the impact of affective reactions attributed to a subgroup of Muslim immigrants in Germany. As predicted, the salience of a negative aspect of a subgroup strengthened self-reported and implicitly measured negative attitudes when the perceived homogeneity of the immigrant group was high, but not when it was low.     

Introducing Real-Time AVHRR-APT Satellite Imagery in the Classroom Environment

A low-cost (US$350) satellite receiving station was assembled and operated within a classroom environment in Gainesville (Florida) on October 2001 for acquiring satellite data directly from the Advanced Very High Resolution Radiometer (AVHRR) satellites. The simplicity of the satellite signal makes this source of real-time satellite data readily accessible to the K-16 educational community. The educational strategy of this program sought to achieve pedagogical effectiveness within the sciences, mathematics, and technology through the cultivation of applied, critical, and analytical skills. The applied hands-on laboratory and lecture experiences aimed at enabling students to visualize and integrate the various concepts presented in the classroom. The characteristics of the satellite data provide students and educators with live visible and infrared images that allow for the visualization and exploration of dynamic scientific concepts, making the AHVRR-APT system a suitable educational tool for complementing the K-16 curricula. This educational experience relied on inexpensive radio equipment for accessing satellite data through the exploration of modern space technology. When compared to Internet-based sources of AVHRR data, the virtual nature of Internet portals cannot provide students with a live satellite data acquisition experience, such as that available through a classroom-based AVHRR-APT satellite receiving station.     

Homework as serious family business: power and subjectivity in negotiations about school assignments in Swedish families

Most previous research on parental involvement in children's homework has focused on the pedagogical advantages or disadvantages of school assignments while neglecting the practice in its social context, family life. By studying parent–child homework negotiations in Swedish families, this paper examines how family members position themselves and each other in relation to Swedish discourses on homework and parental involvement. The study shows that parents want their children to do homework independently. It is hard for the parents to take up another subject position than that of a ‘responsible parent’ who helps the child with homework or controls that it is done. Thereby, the child is simultaneously positioned as ‘irresponsible’ whether that is the case or not.     

Testing moral foundation theory: Are specific moral emotions elicited by specific moral transgressions?

Moral foundation theory posits that specific moral transgressions elicit specific moral emotions. To test this claim, participants (N = 195) were asked to rate their emotions in response to moral violation vignettes. We found that compassion and disgust were associated with care and purity respectively as predicted by moral foundation theory. However, anger, rage, contempt, resentment and fear were not associated to any single moral transgression. Thus, even though the type of moral violation matters for the type of emotion that is elicited, the link between moral foundations and moral emotions seems more complex than moral foundation theory suggests. Rather, the findings suggest that there are both emotion-specific foundations (i.e. care and purity) and emotion-unspecific foundations (i.e. fairness, authority and loyalty).     

Risk and protective factors associated with cyberbullying: Are relationships or rules more protective?

The aim of this paper is to investigate which adolescents are most and least at risk of experiencing online victimization. The results of logistic regression analyses using data on 2079 adolescents attending secondary school in Bermuda indicate that not all forms of media use place adolescents at risk of experiencing cyberbullying. Adolescents who spent more time using their cell phone were more likely to report having received an aggressive or threatening electronic communication and having had someone say nasty things about them online. There was no such relationship between time on the internet and either form of online victimization. The findings also suggest that strong parent relationships and positive experiences at school are generally more protective against cyberbullying than adults’ restrictions on adolescents’ media use. These findings contribute important insight into strategies that hold promise for decreasing cyberbullying among adolescents.     

Academic Motivation and Psychological Needs as Predictors of Suicidal Risk

This study examined academic motivation and basic psychological needs as predictors of suicidal risk (namely, depressive symptoms and suicidal behaviors) in a sample of 348 college students. Results from regression analyses indicated that academic motivation was a significant predictor of suicidal risk. The inclusion of basic psychological needs significantly augmented the prediction model. The authors discuss implications for considering academic motivation and basic psychological needs in college counseling on the basis of the results.     

Visual Guidance in Infants' Reaching toward Suddenly Displaced Targets

This experiment evaluated the role of visual input about the location of a target object and the location of the hand in reaching by infants and adults. 5- and 9-month-old infants were presented with illuminated toys to reach for in a dark room. On no-switch trials, the toy remained illuminated throughout the infant's reach, whereas on switch trials the first-lit toy was replaced during the reach by a second-lit toy at a different position. On approximately half of the trials of each type a luminescent marker was attached to the reaching hand. Adult subjects (tested without the hand marker) fully compensated to the second-lit toy on switch trials, during a second reaching segment. On switch trials, 9-month-olds partially adjusted to the second-lit toy when wearing the hand marker and did not adjust without it. On no-switch trials, 9-month-olds reached just as accurately with or without the hand marker. 5-month-olds were generally inaccurate in their reaching and were unaffected by the presence or absence of the hand marker. The findings suggest that during the development of reaching there is an increase in visual guidance during the approach phase of reaches.