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91.
92.
Yashika Gupta V. Mallika D. K. Srivastava 《Indian journal of clinical biochemistry : IJCB》2005,20(1):87-94
Platelets play a vital role in the progression of atherosclerosis and thrombosis, a major cause of death worldwide. Platelets
are activated by many triggers like elevated LDL in blood resulting in aggregation and formation of plaque. The purpose of
this study was to investigate the effect of LDL and signal transduction inhibitor on the activation of platelets in Ischaemic
risk subjects. Platelets from IHD and hyperlipidemic subjects were hypersensitive to ADP, as higher levels of platelet aggregation
were observed in these groups. LDL from IHD hyperlipidemic subjects was more effective in activating platelets from any other
group. Ox-LDL was more effective in activating platelets than native-LDL as monitored by level of platelet aggregation induced
by PAF and thrombin. Calcium channel blocker, nifedipine and verapamil inhibited platelet aggregation at micromolar level.
Protein kinase inhibitor, staurosporine was effective in inhibiting ADP induced aggregation at nanomolar level. 相似文献
93.
Jacob MC Sturkenboom D 《Isis; an international review devoted to the history of science and its cultural influences》2003,94(2):217-252
The Natuurkundig Genootschap der Dames (Women's Society for Natural Knowledge), formally established by and for women, met regularly from 1785 to 1881 and sporadically until 1887. It challenges our stereotypes both of women and the physical sciences during the eighteenth century and of the intellectual interests open to women in the early European republics. This essay aims not simply to identify the society and its members but to describe their pursuits and consider what their story adds to the history of Western science. What does this society's existence tell us about the relationship between women and early science in general and about science and society in the Dutch setting in particular? Science and gender look rather different when observed through the activities of the immensely prosperous women of Middelburg, citizens of one of the most highly literate Western countries. The elite lives of the first-generation members of the women's society also offer us a glimpse into the early domestication of science, a process vital to its acceptance and assimilation. 相似文献
94.
Urinary citric acid and calcium levels have been estimated in the urine of 20 normal healthy persons as well as 12 urinary
stone patients. Inhibition efficiency of these urine samples towards the mineralisation of urinary stone forming minerals,
viz., calcium phosphate, oxalate or carbonate, has been studied in an experimental model. Statistical correlation of the above
data has been made by computing the coefficient of determination and unexplained variance. Clinico-biochemical indexing of
calcium urolithiasis risk factor has been attempted in the light of the data. 相似文献
95.
K. S. S. Saibaba P. V. L. N. Srinivasa Rao K. V. Dakshina Murty M. Vijaya Bhaskar 《Indian journal of clinical biochemistry : IJCB》1997,12(2):139-141
Selecting the correct method for routine analysis by ‘method evaluation’ is an important component of quality assurance. It
is a step-wise procedure that evaluates various analytical parameters like accuracy, precision etc of the given method. Finally
reference intervals are established for selected population. We evaluated an enzymatic method for serum creatinine. The results
show that it is an acceptable method based on the above mentioned criteria. 相似文献
96.
Lakshmi Lavanya Reddy Swarup A. V. Shah Alpa J. Dherai Chandrashekhar K. Ponde Tester F. Ashavaid 《Indian journal of clinical biochemistry : IJCB》2016,31(1):87-92
Acute coronary syndrome (ACS) is a term for a range of clinical signs and symptoms suggestive of myocardial ischemia. It results in functional and structural changes and ultimately releasing protein from injured cardiomyocytes. These cardiac markers play a major role in diagnosis and prognosis of ACS. This study aims to assess the efficacy of heart type fatty acid binding protein (h-FABP) as a marker for ACS along with the routinely used hs-TropT. In our observational study, plasma h-FABP (cut-off 6.32 ng/ml) and routinely done hs-Trop T (cutoff 0.1 and 0.014 ng/ml) were estimated by immunometric laboratory assays in 88 patients with acute chest pain. Based on the clinical and laboratory test findings the patients were grouped into ACS (n = 41) and non-ACS (n = 47). The diagnostic sensitivity, specificity, NPV, PPV and ROC curve at 95 % CI were determined. Sensitivity of hs-TropT (0.1 ng/ml), hs-TropT (0.014 ng/ml) and h-FABP were 53, 86 and 78 % respectively and specificity for the same were 98, 73 and 70 % respectively. Sensitivity, specificity and NPV calculated for a cut-off combination of hs-TropT 0.014 ng/ml and h-FABP was 100, 51 and 100 % respectively. These results were substantiated by ROC analysis. Measurement of plasma h-FABP and hs-TropT together on admission appears to be more precise predictor of ACS rather than either hs-Trop T or h-FABP. 相似文献
97.
T. Malati G. Rajani Kumari P. V. L. N. Murthy Ch. Ram Reddy B. Surya Prakash 《Indian journal of clinical biochemistry : IJCB》2006,21(1):34-40
Prostate Specific Antigen (PSA) has emerged as the most applicable and important tumor marker for carcinoma prostate. In the
present study PSA was determined in serum of healthy subjects, patients of benign prostate hypertrophy (BPH) and Carcinoma
Prostate (Ca−P) to evaluate its diagnostic efficiency in day to day management of prostate cancer patients and in differentiating
patients of early prostate cancer from those with BPH. Receiver operating characteristic curve (ROC) revealed 2 ng/ml and
10 ng/ml cut off serum PSA level for BPH and untreated carcinoma prostate patients (Ca−P). An extremely significant increase
(P<0.0001) was observed in mean PSA concentration in BPH patients and adenocarcinoma prostate patients when compared to healthy
males. Clinical relevance of PSA was highlighted by a case study of cancer patient prior to any therapy till death. 相似文献
98.
99.
Vaughan Van Hecke A Mundy PC Acra CF Block JJ Delgado CE Parlade MV Meyer JA Neal AR Pomares YB 《Child development》2007,78(1):53-69
Infant joint attention has been observed to be related to social-emotional outcomes in at-risk children. To address whether this relation is also evident in typically developing children, 52 children were tested at 12, 15, 24, and 30 months to examine associations between infant joint attention and social outcomes. Twelve-month initiating and responding to joint attention were related to 30-month social competence and externalizing behavior, even when accounting for 15-month temperament ratings, 24-month cognition and language, and demographic variables. These results suggest that, in addition to associations with language and cognition, infant joint attention reflects robust aspects of development that are related to individual differences in the emergence of social and behavioral competence in childhood. 相似文献
100.
Ortiz R Jiménez JE García Miranda E Guzmán Rosquete R Hernández-Valle I Rodrigo M Estévez A Díaz A Hernández Expósito S 《Journal of learning disabilities》2007,40(1):80-92
The aims of this study were (a) to determine whether Spanish children with reading disabilities (RD) show a speech perception deficit and (b) to explore the locus and nature of this perceptive deficit. A group of 29 children with RD, 41 chronological age-matched controls, and 27 reading ability-matched younger controls were tested on tasks of speech perception. The effect of linguistic unit (word vs. syllable) and type of phonetic contrast (voicing, place and manner of articulation) were analyzed in terms of the number of errors and the response time. The results revealed a speech perception deficit in Spanish children with RD that was independent of the type of phonetic contrast and of linguistic unit. 相似文献