‘The feeling of exclusion’: Young peoples' perceptions of art galleries

This article first looks at the relationship between museums and art galleries and their potential audiences and, in particular, the under-represented sector of young visitors. It examines the main findings from the limited research available on young visitors, and goes on to discuss theories delineating the differences between the cultures, identities and values of culture consumers and culture providers. The second part of the article looks at what specific museums have done towards being more inclusive in their appeal, and then reports the findings of a survey of young people in relation to New Zealand's Auckland Art Gallery. The survey found that young people's ideas of what constitutes modern, relevant art do not match standard art criteria, and that most exhibitions and marketing methods do not mesh with their worldview. The article concludes by using data from the survey to suggest ways of engaging more young people with public art galleries.     

Disciplined freedom,branded authenticity,and dependable independence: how tensions enact flexibility in lifestyle blogging careers

Analyzing 219 blog posts from 52 self-employed women lifestyle bloggers in North America, this study shows how these digital professionals navigate tensions and communicatively constitute work flexibility. In their narratives, women bloggers employed tension management approaches such as reframing, continual connections, and reflective practice in response to tensions in enacting temporal–spatial, identity, and financial flexibility. Specifically, women followed oxymoronic constructions – disciplined freedom, branded authenticity, and dependable independence – to embrace and transform competing poles of fluidity?structure, authenticity?marketability, and independence?interconnection. Expanding work–life research to the self-employed digital labor context, this study responds to recent calls to uncover more-than tension management strategies in empirical settings and contributes to a tension-centered, contextual, and processual analysis of workplace flexibility construction.     

The Information Nature of Culture

This paper explores the information nature of culture. It is represented as an extragenetic and nonorganizational information process and system. Information is regarded as a universal property of matter that is essentially associated with development processes and realizes various forms and ways of storage and circulation at various development stages of global evolution. The socio-cultural principle of exogenous accumulation, transmission, and transformation of information is analyzed in the context of the continuing growth of the information content of material systems on the superhighway of global-universal evolution. It is noted that the information concept of culture evolves into a new area of cultural studies, that is information and cultural studies, advancing our understanding of the nature of culture and cultural genesis.     

Russian Science Citation Index: Areas for Development Identified by Active Users

The current state of the Russian Science Citation Index is analyzed. Several areas for its further development identified by long-standing active users, such as data searching, refinement, and storage; current user alerts; data input with the Science Index license; patent information; and the application programming interface (API) are investigated.     

Effects of purposeful soccer heading on circulating small extracellular vesicle concentration and cargo

BackgroundConsidering the potential cumulative effects of repetitive head impact (HI) exposure, we need sensitive biomarkers to track short- and long-term effects. Circulating small extracellular vesicles (sEVs) (<200 nm) traffic biological molecules throughout the body and may have diagnostic value as biomarkers for disease. The purpose of this study was to identify the microRNA (miRNA) profile in circulating sEVs derived from human plasma following repetitive HI exposure.MethodsHealthy adult (aged 18–35 years) soccer players were randomly assigned to one of 3 groups: the HI group performed 10 standing headers, the leg impact group performed 10 soccer ball trapping maneuvers over 10 min, and the control group did not participate in any soccer drills. Plasma was collected before testing and 24 h afterward, and sEVs were isolated and characterized via nanoparticle tracking analysis. Next-generation sequencing was utilized to identify candidate miRNAs isolated from sEVs, and candidate microRNAs were analyzed via quantitative polymerase chain reaction. In silico target prediction was performed using TargetScan (Version 7.0; targetscan.org) and miRWalk (http://mirwalk.umm.uni-heidelberg.de/) programs, and target validation was performed using luciferase reporter vectors with a miR-7844-5p mimic in human embryonic kidney (HEK) 293T/17 cells.ResultsPlasma sEV concentration and size were not affected across time and group following repetitive HI exposure. After 24 h, the HI read count from next-generation sequencing showed a 4-fold or greater increase in miR-92b-5p, miR-423-5p, and miR-24-3p and a 3-fold or greater decrease in miR-7844-5p, miR-144-5p, miR-221-5p, and miR-22-3p. Analysis of quantitative polymerase chain reaction revealed that leg impact did not alter the candidate miRNA levels. To our knowledge, miR-7844-5p is a previously unknown miRNA. We identified 8 miR-7844-5p mRNA targets: protein phosphatase 1 regulatory inhibitor subunit 1B (PPP1R1B), LIM and senescent cell antigen-like domains 1 (LIMS1), autophagy-related 12 (ATG12), microtubule-associated protein 1 light chain 3 beta (MAP1LC3B), integrin subunit alpha-1 (ITGA1), mitogen-activated protein kinase 1 (MAPK1), glycogen synthase kinase 3β (GSK3β), and mitogen-activated protein kinase 8 (MAPK8).ConclusionCollectively, these data indicate repetitive HI exposure alters plasma sEV miRNA content, but not sEV size or number. Furthermore, for the first time we demonstrate that previously unknown miR-7844-5p targets mRNAs known to be involved in mitochondrial apoptosis, autophagy regulation, mood disorders, and neurodegenerative disease.