Performance evaluation of the high sensitive troponin I assay on the Atellica IM analyser

IntroductionThe Fourth Universal Definition of Myocardial Infarction Global Taskforce recommends the use of high sensitive troponin (hs-Tn) assays in the diagnosis of acute myocardial infarction. We evaluated the analytical performance of the Atellica IM High-sensitivity Troponin I Assay (hs-TnI) (Siemens Healthcare Diagnostics Inc., Tarrytown, USA) and compared its performance to other hs-TnI assays (Siemens Advia Centaur, Dimension Vista, Dimension EXL, and Abbott Architect (Wiesbaden, Germany)) at one or more sites across Europe.Materials and methodsPrecision, detection limit, linearity, method comparison, and interference studies were performed according to Clinical and Laboratory Standards Institute protocols. Values in 40 healthy individuals were compared to the manufacturer’s cut-offs. Sample turnaround time (TAT) was examined.ResultsImprecision repeatability CVs were 1.1–4.7% and within-lab imprecision were 1.8–7.6% (10.0–25,000 ng/L). The limit of blank (LoB), detection (LoD), and quantitation (LoQ) aligned with the manufacturer’s values of 0.5 ng/L, 1.6 ng/L, and 2.5 ng/L, respectively. Passing-Bablok regression demonstrated good correlations between Atellica IM analyser with other systems; some minor deviations were observed. All results in healthy volunteers fell below the 99th percentile URL, and greater than 50% of each sex demonstrated values above the LoD. No interference was observed for biotin (≤ 1500 µg/L), but a slight bias at 5.0 g/L haemoglobin and 50 ng/L Tn was observed. TAT from was fast (mean time = 10.9 minutes) and reproducible (6%CV).ConclusionsReal-world analytical and TAT performance of the hs-TnI assay on the Atellica IM analyser make this assay fit for routine use in clinical laboratories.     

Using Photographs to Assess Equity Climate: A Taxonomy

Our challenge as teachers and as human beings is to begin the process of "changing our voices," facing who we are and what that means in a society based on power and oppression. We must learn to listen to others, so we can speak together with voices both united and unique. The journey described is personal, yet it is also generalizable. Changing one's voice may be the only real way in which a teacher can be a model of diversity and multiculturalism. If as a teacher I do nothing to change my own voice, I have accomplished little in terms of effective teaching. My attitudes, behaviors, words should reflect and embody humanity, not just those who "look" like me or are thought of as more capable learners. I must challenge my students' thinking in terms of diversity and multicultural issues and push them to think of the "other."     

Wrestling Whiteness: Three Stages of Shifting Multicultural Perspectives among White Pre-service Teachers

Pedagogical progress in the field of multicultural education moves at a snail's pace due to pre-service teachers' level of acceptance of multiculturalism and its tenets. Teacher candidates and seasoned teachers are simply unconscious and apathetic about matters of diversity. Pre-service teachers, primarily White and middle class, are mandated to take multicultural courses and grapple with recognizing their own cultural beings and the cultural realities of others. While student populations grow more diverse, the pre-service teacher population is becoming more homogenous. A major obstacle in teacher preparation programs arising from this mismatch of teacher and student cultures is the ability to facilitate a critical consciousness. This includes the ability to analyze the world and employ equity pedagogy in pre-service teachers who are resistant to diversity issues.

Pre- and post-course surveys, in open-ended and anonymous narrative form, were administered to White pre-service teachers (= 94), and this article is divided into two sections based on the results. First, I outline the three shifting perspectives that were identified during a semester-long course with White and middle class pre-service students, and then connect these perspectives to existing research on racial identity ego, theorizing whiteness, and curriculum integration. This new theoretical model addresses equity pedagogy and is framed within whiteness and consciousness studies and may serve as a reflective tool for educators to self-evaluate their pedagogical proclivities. Second, the implications of this informal action research project for White pre-service educators and research in theorizing whiteness are developed.     

A “suitably dead” woman: Grieving Andrea Dworkin

This article investigates the discursive register through which lives become grievable by focusing on a case study of the discourses surrounding the death of radical feminist, Andrea Dworkin. I argue that Dworkin becomes embroiled in an interlocking nexus of illicit subject positions that set the terms of her grievability and obstruct recognition of her as a rational being by framing her (1) as the quintessential emotional and irrational woman who is not worthy of the respect typically offered to the dead and (2) in relation to her wild, unruly, and excessive body, which is conflated with her feral work.     

Presidential policy and information dissemination: An analysis of the Reagan moratorium on government publishing

In 1981, President Reagan declared a moratorium on the production of new government-financed pamphlets, periodicals, and audiovisuals. This study examines the impact of that action on the format and content of printed publications, issued during the freeze, by the Department of Health and Human Services. Analysis of those publications distributed to Government Printing Office depository libraries during the moratorium reflected: (1) no significant reduction in the number of documents produced, (2) a shift toward smaller, less-costly print formats, and (3) no significant reduction in the release of publicity/advertising materials. Changes observed in the quantity, format, and content of Department of Health and Human Services publications issued during the moratorium were not those expected given the presidential guidelines.     

Teaching with student response systems in elementary and secondary education settings: A survey study

This study examined how 498 elementary and secondary educators use student response systems in their instruction. The teachers all completed an online questionnaire designed to learn about their goals for using response systems, the instructional strategies they employ when using the system, and the perceived effects of response systems. Participants in the study tended to use similar instructional strategies when using the technology as have been reported in higher education. These include posing questions to check for student understanding and diagnose student difficulties, sharing a display of student responses for all to see, asking students to discuss or rethink answers, and using feedback from responses to adjust instruction. A latent class analysis of the data yielded four profiles of teacher use based on frequency of use and breadth of instructional strategies employed. Teachers who used the technology most frequently and who employed broadest array of strategies were more likely to have received professional development in instructional strategies and to perceive the technology as more effective with students.     

Sociocultural Perspectives on Transition to School from Pacific Islands Early Childhood Centres

Sociocultural theories of learning and development underpin a number of studies of young children's experiences as they move from early childhood education centres to school settings. This paper summarises research designed to investigate children's transition to primary school from Pacific early childhood centres in New Zealand. The study records experiences of transition to school of families from each of five Pacific groups (Cook Islands, Niue, Samoa, Tokelau, and Tonga). The emphasis is on language and children's other experiences as they move from Pacific Islands early childhood centres into English-language primary schools. Findings from in-depth interviews with children, parents, early childhood teachers, and school teachers are summarised, and brief reference is also made to analyses of the content of the 19 participating schools' charters. The paper draws on sociocultural perspectives to comment on aspects of facilitating transition. Les the´ories socioculturelles d'apprentissage et de de´veloppement soutiennent un certain nombre d'e´tudes sur les expe´riences des petits enfants pendant qu'ils se de´placent des centres d'e´ducation de la petite enfance a ¤ un cadre d'e´cole. Cet article re´sume la recherche conc¸ue pour e´tudier la transition des enfants a ¤ l'e´cole primaire des centres d'e´ducation de la petite enfance d'iles Pacifiques en Nouvelle-Ze´lande. Cette e´tude enregistre des expe´riences de transition a ¤ l'e´cole des familles de chacun de cinq groupes Pacifiques (iles Cook, Nioue´, Samoa, Toke´lao, et Tonga). L'emphase est sur la langue et les autres expe´riences des enfants pendant qu'ils se de´placent des centres d'e´ducation de la petite enfance d'iles Pacifiques dans les e´coles primaires de langue anglaise. Des re´sultats des entrevues de´taille´es avec des enfants, avec des parents, avec des enseignants spe´cialise´s dans l'e´tude la petite enfance, et des enseignants d'e´cole sont re´sume´s, et on fait une re´fe´rence bre ¤ ve aux analyses du contenu des chartes des 19 e´coles qui participent. L'article tire sur des perspectives socioculturelles pour faire des observations sur des aspects de la facilitation de la transition. Las teori´as socio-culturales del aprendizaje y el desarrollo apuntalan un nu´mero de estudios sobre las experiencias de nin ¨ os pequen ¨ os cuando pasan de los centros de educacio´n para la primera infancia al medio de la escuela. Este ensayo resume la investigacio ´n disen ¨ ada para investigar la transicio´n de los nin ¨ os a la escuela primaria de centros preescolares del Paci´fico en Nueva Zelanda. El estudio registra experiencias de la transicio´n a la escuela de familias de cada uno de cinco grupos del Paci´fico (islas Cook, Niue, Samoa, Tokelau, y Tonga). El e´nfasis esta´ en el lenguaje y las otras experiencias por las que pasan los nin ¨ os al desplazarse de los centros pre-escolares de las Islas del Paci´fico a las escuelas primarias de lengua inglesa. Se resumen aqui´ los resultados de entrevistas detalladas con los nin ¨ os, los padres, los maestros de la primera infancia, los ensen ¨ antes de escuela y se hace breve referencia a los ana´lisis del contenido de los estatutos de las 19 escuelas que participan. El ensayo utiliza las perspectivas socioculturales para comentar sobre los aspectos de la facilitacio´n de esta transicio´n.