Lipoproteins and cholesterol homeostasis in paediatric nephrotic syndrome patients

IntroductionThe aim of this study was to investigate lipoprotein particle distributions and the likelihood of achieving cholesterol homeostasis in the remission phase of nephrotic syndrome (NS) in paediatric patients. We hypothesized that lipoprotein particle distributions moved toward less atherogenic profile and that cholesterol homeostasis was achieved.Materials and methodsThirty-three children, 2 to 9 years old with NS were recruited. Blood sampling took place both in the acute phase and during remission. Serum low-density lipoprotein particles (LDL) and high-density lipoprotein particles (HDL) were separated using non-denaturing polyacrylamide gradient gel (3-31%) electrophoresis. Serum non-cholesterols sterols (NCSs), desmosterol, lathosterol, 7-dehydrocholesterol (7-DHC), campesterol and β-sitosterol were measured by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS).ResultsAll patients had desirable serum HDL cholesterol concentrations during remission. The dominant lipoprotein diameters and LDL subclass distribution did not change significantly during follow-up. In contrast, HDL lipoprotein particle distribution shifted towards larger particles. The absolute concentration of desmosterol was significantly lower during remission (P = 0.023). β-sitosterol concentration markedly increased during remission (P = 0.005). Desmosterol/β-sitosterol (P < 0.001) and 7-DHC/β-sitosterol (P = 0.005) ratios significantly declined during disease remission.ConclusionsFavourable changes in the serum lipid profiles, HDL particle subclass distribution and cholesterol metabolism in paediatric patients with NS during remission took place. For the first time, we found that cholesterol homeostasis changed in favour of increased cholesterol absorption during disease remission. Nevertheless, complete cholesterol homeostasis was not achieved during disease remission.     

Methodological Challenges of Digital Divide Measurements

The term “digital divide” has been used for almost a decade and typically relates to sociodemographic differences in the use of information and communication technology. However, the corresponding measurement is still relatively imprecise. Very often it is simply reduced to comparisons of Internet penetration rates. This article extends the measurements above the usual bivariate comparisons. Within this context, three essential approaches are presented and critically evaluated. First, loglinear modeling is used to address the interactions among the factors affecting the digital divide. Second, compound measures (i.e., the Digital Divide Index) that integrate a number of variables into a single indicator are discussed. Third, time-distance methodology is applied to analyze changes in the digital divide. The article argues that these approaches often yield entirely different conclusions compared to simple bivariate analysis. The examples are presented as a general warning against an oversimplified methodological approach to digital divide studies.     

Erasmus student mobility flows

This article identifies student mobility flows using Erasmus data from 2007–2008 to 2013–2014. We used the software programmes “R” for statistical analysis and “Pajek” for analysis of networks. Findings provide an overview of student mobility from three perspectives. We find the most balanced relative outbound and inbound mobility in Spain, Switzerland, Austria and Poland. Moreover, Spain and Italy exchange the most students between each other. Overall, the core centres for student mobility are Spain, France, Germany and Italy. Smaller countries, such as Luxemburg, Malta and Liechtenstein, have large numbers of mobile students considering the size of the country's student population. The network analysis revealed three groups of countries: (1) good receivers and senders (Spain, Italy, and Germany), (2) good receivers only (Finland, Sweden, the United Kingdom and Portugal) and (3) good senders only (Belgium and the Czech Republic).     

Prospects for inclusive education in European countries emerging from economic and other trauma: Serbia and Albania

This paper examines recent historical, social and economic factors in Albania and Serbia, identifying similarities and differences that have a bearing on the provision of education. The focus is on the education of children with difficulties in learning and/or disabilities (the term ‘special needs’ is used for brevity). The paper provides a summary of the past and present situation of children with special needs in both countries. The role and motivation of international non‐governmental organizations (NGOs) involved in funding and developing inclusive educational policies and practices in both countries are examined. There are substantial barriers to inclusive education in Albania and Serbia. These are identified and discussed before examining more recent positive developments in both countries. Two individual examples of schools that are making progress are profiled, one from each country. Finally, the prospects for the future in both countries are examined, and the prediction made that in‐country efforts and developments will result in further slow and uneven progress towards inclusive education in Albania and Serbia. For any of this to happen, however, it will be important that conditions of economic recovery, social stability, the political drive towards Europe and its inclusive standards, and further help from international NGOs, prevail.