Antipsychotics-induced hyperprolactinemia and screening for macroprolactin

IntroductionHigh prolactin (PRL) concentrations are found in laboratory test results of patients on majority of antipsychotic drugs. Prevalence rates and degrees of severity of hyperprolactinemia (HPRL) based on PRL concentration may depend on the presence of macroprolactin in the serum. The aim of the study was to investigate the difference between PRL concentrations before and after precipitation of macroprolactin and to examine if there were any changes in the categorization of HPRL between samples prior and after precipitation.Materials and methodsTotal of 98 female patients (median age 33; range 19-47 years) diagnosed with a psychotic disorder, proscribed antipsychotic drugs, and with HPRL were included. Total PRL concentration and PRL concentration after macroprolactin precipitation with polyethylene glycol (postPEG-PRL) were determined by the chemiluminometric method on the Beckman Coulter Access2 analyser.ResultsTotal PRL concentrations (median 1471; IQC: 1064-2016 mlU/L) and postPEG-PRL concentrations (median 1453; IQC: 979-1955 mlU/L) were significantly correlated using intraclass correlation coefficient for single measurements (mean estimation 0.96; 95%CI 0.93-0.97) and average measurement (mean estimation 0.98; 95%CI 0.96-0.99), and all investigated female patient had HPRL according to PRL and postPEG-PRL concentration. The median PRL recovery following PEG precipitation was 95; IQC: 90-100%. There was substantial agreement (kappa test = 0.859, 95% CI: 0.764-0.953) between the categories of HPRL severity based on total PRL concentrations and postPEG-PRL concentrations.ConclusionThe study demonstrated that HPRL was present in all subjects using the reference interval for total PRL concentration and postPEG-PRL concentration with no significant impact of macroprolactin presence in the serum on the categorization of patients according to severity of HPRL.     

Science Letters： Vascular architecture： is it a helpful histopathological biomarker for hepatocellular carcinoma？

Hepatocellular carcinoma （HCC） remains one of the major public health problems throughout the world. Although originally associated with tumorigenic processes, liver angiogenesis has also been observed in the context of different liver inflammatory, fibrotic, and ischemic conditions. Here we investigate the fractal dimension as a quantitator of non-Euclidean two-dimensional vascular geometry in a series of paired specimens of primary HCC and surrounding non-tumoral tissue, and discuss why this parameter might provide additional information regarding cancer behavior. The application of fractal geometry to the measurement of liver vascularity and the availability of a computer-aided quantitative method can eliminate errors in visual interpretation, and make it possible to obtain closer-to-reality numerals that are compulsory for any measurement process.     

Transformations in Cultural Communication: Social Media,Cultural Exchange,and Creative Connections

Abstract Throughout the cultural institution sector, shifts in audience participation call for new ways to share knowledge and view partnerships both online and onsite. Increasingly, this “transformation in cultural communication” suggests that a new type of mutually beneficial exchange is required between audiences and museums; and that those acting as agents of cultural change must be cognizant of how a participatory culture will drive our future institutional missions. This paper offers two examples of how the implementation of strategic social media programs can drive online cultural exchange and create new connections with diverse communities. It presents a convergence of initiatives undertaken within the sector over the past five years while offering a frame through which to view future innovations. Based on research undertaken with multiple organizations, it recognizes that the time is right to merge existing innovations with strategically developed communication programs to achieve a demonstrable, verifiable basis for the value of our museums.     

Preparing our Societies for the Multimedia Environment: Ukrainian Experience and the Need for International Co-operation in Digital Literacy

The Ukrainian Society, after introducing the computer literacy course for secondary schools in 1986, is trying to reach the next stage of digital literacy through the development of a National Informatization Programme. Some results of the programme are described: the incorporation of telematics into the educational system and Internet literacy for teachers and students, free of charge and in local languages; the development of regional and local nodes of educational institutions and their incorporation into a national network; the participation of non-governmental organizations in the financing of educational programmes; and the development of a national ethics Net-Codex. Ukraine, as a typical “country in transition”, needs international support in digital literacy through co-operative projects; some proposals for such co-operation are given.     

The social-cognitive mechanisms regulating adolescents' use of doping substances

In this study, we assessed the longitudinal effects of social-cognitive mechanisms on the self-reported use of doping substances and supplements among Italian high school students. In total, 1232 students completed questionnaires measuring various psychological factors hypothesized to influence students' intention to use substances. Three months later, 762 of the students completed the same questionnaires a second time and also reported their use of substances during the time between assessments. Overall, the percentages of students using doping substances (2.1%) or supplements (14.4%) were consistent with values reported in the literature. Analysis of the data showed that adolescents' intention to use doping substances increased with stronger attitudes about doping, stronger beliefs that significant others would approve of their use, a stronger conviction that doping use can be justified, and a lowered capacity to resist situational pressure or personal desires. In turn, stronger intentions and moral disengagement contributed to a greater use of doping substances during the previous 3 months. Doping use was also correlated significantly to supplementation. In conclusion, our results provide novel information about some of the psychological processes possibly regulating adolescents' use of doping substances and supplements. The results also highlight possible areas for future study and intervention, focusing on the prevention of adolescents' substance use.     

The Financial Situation of the Higher Education System of the Russian Federation

For a number of reasons, higher education in the Russian Federation has been able to benefit from a more stable financial situation than have most of the other “socio‐cultural areas” in Russia. It has nevertheless been severely affected by the problems besetting the other sectors of the Russian economy, most of them linked to the rigours of transition to a market economy. The situation will improve as the Russian economy as a whole improves and as higher education in Russia not only becomes more market‐oriented and quality conscious but adopts specific administrative measures designed to ensure efficiency.     

Estimation fusion of nonlinear cost functions with application to multisensory Kalman filtering

This paper focuses on four fusion algorithms for the estimation of nonlinear cost function (NCF) in a multisensory environment. In multisensory filtering and control problems, NCF represents a nonlinear multivariate functional of state variables, which can indicate useful information of the target systems for automatic control. To estimate the NCF using multisensory information, we propose one centralized and three decentralized estimation fusion algorithms. For multivariate polynomial NCFs, we propose a simple closed-form computation procedure. For general NCFs, the most popular procedure for the evaluation of their estimates is based on the unscented transformation. The effectiveness and estimation accuracy of the proposed fusion algorithms are demonstrated with theoretical and numerical examples.     

Asymmetry of red blood cell motions in a microchannel with a diverging and converging bifurcation

In microcirculation, red blood cells (RBCs) flowing through bifurcations may deform considerably due to combination of different phenomena that happen at the micro-scale level, such as: attraction effect, high shear, and extensional stress, all of which may influence the rheological properties and flow behavior of blood. Thus, it is important to investigate in detail the behavior of blood flow occurring at both bifurcations and confluences. In the present paper, by using a micro-PTV system, we investigated the variations of velocity profiles of two working fluids flowing through diverging and converging bifurcations, human red blood cells suspended in dextran 40 with about 14% of hematocrit level (14 Hct) and pure water seeded with fluorescent trace particles. All the measurements were performed in the center plane of rectangular microchannels using a constant flow rate of about 3.0 × 10⁻¹² m³/s. Moreover, the experimental data was compared with numerical results obtained for Newtonian incompressible fluid. The behavior of RBCs was asymmetric at the divergent and convergent side of the geometry, whereas the velocities of tracer particles suspended in pure water were symmetric and well described by numerical simulation. The formation of a red cell-depleted zone immediately downstream of the apex of the converging bifurcation was observed and its effect on velocity profiles of RBCs flow has been investigated. Conversely, a cell-depleted region was not formed around the apex of the diverging bifurcation and as a result the adhesion of RBCs to the wall surface was enhanced in this region.