Sars-Cov2 Induced Biochemical Mechanisms in Liver Damage and Intestinal Lesions

Multiple pathogenic mechanisms are found in SARS-CoV2 systemic inflammation. Oxidative stress, altered proteolysis, hypercoagulation, and metabolic disorders are significant in virus-induced lesions.The study aimed to investigate the biochemical mechanism of virus-induced disorders and determine the biochemical features in SARS-CoV2-associated liver damage and intestine lesions.A retrospective case series of ninety-two patients diagnosed with COVID-19 pnemonia. The ACE, α1-proteinase inhibitor, trypsin-like proteinase, and elastase activity were measured. Nitrites level was detected in reaction with Griess reagent. The ELISA kit measured Troponin, C-peptide, leptin, adiponectin, PAR4, and neuropilin level.It was obtained an increase in ACE activity and nitrites ions content in SARS-CoV2 associated patients. The hyperglycemia and an increase in adipose tissue-derived hormones guided the virus-induced metabolic disorders. Proteolysis activation was revealed in SARS-CoV2 pneumonia patients. The found molecular event was accompanied by hyperglycemia induction. Multiorgan lesions manifest in in cardiac failure, which was detected in patients with ARDS. Moreover, high arterial blood pressure in patients with COVID-19 was associated with the hyperglycemia and increased ACE activity and NO ions level. Liver damage was specific for COVID-19-associated patients with severe ARDS and heart failure. Proteolysis overactivation resulting in vasoactive substances imbalance was detected in patients with the intestinal lesions. The obtained data shows the the neuropilin-dependent axis in damage prevalence in the intestine.Metabolic disorders resulting in the growth of adipose-derived tissue hormones, nitrites, and neuropilin levels was triggered by prolonged inflammation. So, the impaired metabolism and SARS-CoV2 associated hyperglycemia influence on SARS-CoV2 multiple mechanisms. Gastrointestinal manifestations in SARS-CoV2 infection was found to be related to various biochemical and molecular tools. ACE2 receptors axis is prevalent for liver damage, but NRP-1 protein (neuropilin), NO derivatives, and adipose tissue-derived hormones are essential for intestinal lesions.Supplementary InformationThe online version contains supplementary material available at 10.1007/s12291-022-01089-x.     

The rights to educational self-determination under the Individuals with Disabilities Education Act

ABSTRACT

The United States Senate's unwillingness to ratify the Convention on the Rights of the Child (CRC) notwithstanding, the Individuals with Disabilities Education Act (IDEA) contains significant safeguards protecting the rights of students with disabilities, acknowledging their participation rights in decisions about their futures. In the first of just two examples, as students ‘age out’ of special education, they participate in developing individualised transition plans guiding their movements to post-school activities. Second, the IDEA transfers parental access rights to students, granting them sole control over their educational records on turning 18 unless they are adjudicated incompetent under state law.

Against this background, this paper opens by considering the U.S. Senate's reluctance to ratify the CRC. The paper next reviews the history of rights in the U.S. before examining how the IDEA affords students with disabilities considerable opportunities to participate in planning their futures both through transition planning and taking control over their educational records. The article ends by reflecting on how the IDEA comports with the CRC in protecting the rights of students with disabilities to self-determination.     

Who gets what? Impact of financial aid policies

Because of the radical reorientation of financial aid policies in the eighties, loan indebtness and the amount of federal subsidy of loans have increased dramatically. Paralleling these developments has been the growth of the proprietary sector of postsecondary education and the use of federal-supported financial aid by this sector's students. This article examines the impact of current financial aid policies on different sectors. Evidence appears clear that new policy is required to serve equity and human and social capital development. The success of the proprietary sector in growing its market share at the expense of other sectors—in particular, community colleges—provides some useful lessons about aggressive recruiting.     

Will it be possible to integrate young people in a society undergoing transformation?

Ph.D. Senior researcher at the Scientific Research Centre of the Institute of Youth (Moscow). Specialist in studies of youth policies and civil society. Author ofInternational experience of public support of the youth organizations (1995) andSituation and prospects of social voluntary action in Russia (1995).     

EFFECTIVENESS OF THE FRIENDS FOR LIFE PROGRAM IN PORTUGUESE SCHOOLS: STUDY WITH A SAMPLE OF HIGHLY ANXIOUS CHILDREN

The FRIENDS for Life program is a cognitive–behavioral group program that targets anxiety in children. The main purpose of this study was to analyze the effectiveness of the Portuguese version of the FRIENDS for Life Program, which was implemented in schools to reduce anxiety problems in a group of highly anxious children. The study used a quasi‐experimental research design with two groups of children, an intervention (n = 17) and a wait‐list control group (n = 21), aged 8 to 12 years old. The impact of the program in reducing anxiety symptoms as assessed by children and mothers was analyzed through the Screen for Child Anxiety Related Emotional Disorders‐Revised (SCARED‐R). The results show a statistically significant post intervention effect on anxiety symptoms evaluated by the child, but not by the mother. The implications of these results for the prevention of anxiety disorders in Portuguese schools are discussed.     

Auditory dominance and its change in the course of development

Young children often have a preference for auditory input, with auditory input often overshadowing visual input. The current research investigated the developmental trajectory and factors underlying these effects with 137 infants, 132 four-year-olds, and 89 adults. Auditory preference reverses with age: Infants demonstrated an auditory preference, 4-year-olds switched between auditory and visual preference, and adults demonstrated a visual preference. Furthermore, younger participants were likely to process stimuli only in the preferred modality, thus exhibiting modality dominance, whereas adults processed stimuli in both modalities. Finally, younger participants ably processed stimuli presented to the nonpreferred modality when presented in isolation, indicating that auditory and visual stimuli may be competing for attention early in development. Underlying factors and broader implications of these findings are discussed.