Yangxueqingnao particles inhibit rat vascular smooth muscle cell proliferation induced by lysophosphatidic acid

Objective: To observe the effect of Yangxueqingnao particles on rat vascular smooth muscle cell (VSMC) proliferation induced by lysophosphatidic acid (LPA). Methods: The amount of3H-TdR (3H-thymidine) admixed in cultured rat VSMC was measured and mitogen-activated protein kinase (MAPK) activity and lipid peroxidation end product malondialdehyde (MDA)content of the VSMC were assayed. Results: 1×10-9, 1×10-8, 1×10-7 mol/L LPA in a concentration dependent manner, induced the amount of 3H-TdR admixed, MAP kinase activity, and MDA content of the cultured rat VSMC to increase. However, 5%, 10%,and 15% Yangxueqingnao serum preincubation resulted in a decrease of 23.0%, 42.0%, and 52.0% (P＜0.01) respectively in the amount of 3H-TdR admixed, a decline in VSMC MAP kinase activity of 13.9% (P＜0.05), 29.6% (P＜0.01), and 48.9% (P＜0.01)respectively, and also, a decrease in MDA content of VSMC of 19.4%, 24.7%, and 43.2% (P＜0.01) respectively, in the 1×10-7mol/L LPA-treated VSMC. Conclusions: LPA activates the proliferation and lipid peroxidation of VSMC in a concentration dependent manner. The LPA-induced VSMC proliferation is related to the activity of MAP kinases, enzymes involved in an intracellular signalling pathway. The results of the present study showed that Yangxueqingnao particles can effectively inhibit LPA-induced VSMC proliferation, MAP kinase activation, and reduce lipid peroxidative lesion.     

Diversity of Gram negative bacteria antagonistic against major pathogens of rice from rice seed in the tropic environment

INTRODUCTIONRiceseedharborsadozenofplantpathogen icbacteria (Gotoetal.,1 988;Xieetal.,1 998) .Thebacterialpathogenscausearangeofricediseases,someverydestructivewhileothershavenoeffectonricecropgrowth .Inthisstudy ,wefoundalargenumberofbacteriaasso ciatedw…     

Parameters in television captioning for deaf and hard-of-hearing adults: effects of caption rate versus text reduction on comprehension

Caption rate and text reduction are factors that appear to affect the comprehension of captions by people who are deaf or hard of hearing. These 2 factors are confounded in everyday captioning; rate (in words per minute) is slowed by text reduction. In this study, caption rate and text reduction were manipulated independently in 2 experiments to assess any differential effects and possible benefits for comprehension by deaf and hard-of-hearing adults. Volunteers for the study included adults with a range of reading levels, self-reported hearing status, and different communication and language preferences. Results indicate that caption rate (at 130, 180, 230 words per minute) and text reduction (at 84%, 92%, and 100% original text) have different effects for different adult users, depending on hearing status, age, and reading level. In particular, reading level emerges as a dominant factor: more proficient readers show better comprehension than poor readers and are better able to benefit from caption rate and, to some extent, text reduction modifications.     

西德尼.哈里斯漫画

砂秘辱如.诬西德尼.哈里斯漫画@西德尼.哈里斯~~     

我的科学经历

回想起来,在我成长过程中,既有与众不同的地方,也有许多很平凡的地方。在上高中以前,我完全没有机会接触科学,对于科学的作用几乎一无所知。就是上高中以后,我的主要精力     

春的畅想曲

又一个春天要过去了,这段日子里,承载了我怎样的记忆和思绪。人们都说,这应该是一个灿烂明媚的季节。可是我印象中,只留下了阴沉压抑的天空。记忆中,关于春天的概念,还是充满生机与希望,但是夹在冬季与夏季这两个醒目的季节之间的那段日子,却是那般的暗淡与模糊。可以说,夏天和     

箭与歌

我向空中射出一枝箭,我不知它落在何方。因为它飞得如此神速,我的视力都追赶不上。我向高空唱出一支歌,我不知它落在何方。谁有如此犀利眼力,能追赶上歌声的飞扬?     

书写自己的生命华章

假如有人给你一支笔,一支密封的、纯色的水笔,里面有多少墨水你无法看到,很可能刚刚试着写几个字就能用干,也可能足够写一部或几部皇皇巨著,流传千古,使世事为之而改变。而这一切你在动笔之前无法知晓。     

Kinetics study on biomass pyrolysis for fuel gas production

INTRODUCTIONSincebiomassisanabundant,inexpensiveandrenewableresource ,itsconversiontosyn theticfuelsandchemicalproductsappearsat tractive.Amongallkindsofbiomassconversionroutes,pyrolysisisbeinggivenincreasingatten tionsincetheprocessissimpleandmaybeopti m…