Circulating Cell-Free DNA Level in Prediction of COVID-19 Severity and Mortality: Correlation of with Haematology and Serum Biochemical Parameters

Lymphocyte dysregulation in coronavirus disease-19 (COVID-19) is a major contributing factor linked to disease severity and mortality. Apoptosis results in the accumulation of cell-free DNA (cfDNA) in circulation. COVID-19 has a heterogeneous clinical course. The role of cfDNA levels was studied to assess the severity and outcome of COVID-19 patients and correlated with other laboratory parameters. The current case series included 100 patients with mild COVID-19 (MCOV-19) and 106 patients with severe COVID-19 (SCOV-19). Plasma cfDNA levels were quantified using SYBR green quantitative real-time PCR through amplification of the β-actin gene. CfDNA level was significantly higher in SCOV-19 at 706.7 ng/ml (522.6–1258) as compared to MCOV-19 at 219.8 ng/ml (167.7–299.6). The cfDNA levels were significantly higher in non-survivor than in survivors (p = 0.0001). CfDNA showed a significant correlation with NLR, ferritin, LDH, procalcitonin, and IL-6. The diagnostic sensitivity and specificity of cfDNA in the discrimination of SCOV-19 from MCOV-19 were 90.57% & 80%, respectively. CfDNA showed a sensitivity of 94.74% in the differentiation of non-survivors from survivors. CfDNA levels showed a significant positive correlation with other laboratory and inflammatory markers of COVID-19. CfDNA levels, NLR, and other parameters may be used to stratify and monitor COVID-19 patients and predict mortality. CfDNA may be used to predict COVID-19 severity with higher diagnostic sensitivity.     

Temporal expert profiling: With an application to T-shaped expert finding

Cost optimization continues to be a critical concern for many human resources departments. The key is to balance between costs and business value. In particular, computer science organizations prefer to hire people who are expert in only one skill area and have a slight superficial knowledge in other areas that gives them the ability to collaborate across different aspects of project. Community Question Answering networks provide good platforms for people and organizations to share knowledge and find experts. An important issue in expert finding is that an expert has to constantly update his knowledge after being saturated in his field of expertise to still be identified as expert. A person who fails to preserve his expertise is likely to lose his expertise. This work justifies this question that does take the concept of time into account improve the quality of expertise retrieval. We propose a new method for T-shaped expert finding that is based on temporal expert profiling. The proposed method takes the temporal property of expertise into account to mine the shape of expertise for each candidate expert based on his profile. To this end, for each candidate expert, we take snapshots of his expertise trees at regular time intervals and learn the relation between temporal changes in different expertise trees and candidates’ profile. Finally, we use a filtering technique that is applied on top of the profiling method, to find shape of expertise for candidate experts. Experimental results on a large test collection show the superiority of the proposed method in terms of quality of results in comparison with state-of-the-art.     

Validation of the short form of the career development inventory with an Iranian high school sample

A short 33-item form of the Career Development Inventory was validated on a sample of 310 Iranian high school students. Factor analysis indicated that attitude and cognitive subscale items loaded on their respective factors, and that internal reliability coefficients at all levels were satisfactory to good. Support for validity was demonstrated by associations in the expected direction for career decidedness and career decision-making self-efficacy. This short form of the inventory shows promise as a measure of career maturity with students from a non-Western country.     

Finite element analysis and modeling of water absorption by date pits during a soaking process

Date pits for feed preparation or oil extraction are soaked in water to soften before milling or extrusion. Knowledge of water absorption by the date pits helps in better managing the soaking duration. In this research, the process of water absorption by date pits was modeled and analyzed using Fick's second law of diffusion, finite element approach, and Peleg model. The moisture content of the pits reached to its saturation level of 41.5% (wet basis) after 10 d. The estimated coefficient of diffusion was 9.89×10-12 m2/s. The finite element model with a proposed ellipsoid geometry for a single date pit and the analytical model fitted better to the experimental data with R2 of 0.98. The former model slightly overestimated the moisture content of the pits during the initial stages of the soaking and the latter model generally underestimated this variable through the entire stages of soaking process.     

Bread wheat varieties as influenced by different nitrogen levels

INTRODUCTION Dera Ismail Khan lies in Pakistan’s arid zone (71.07° longitude, 31.57° latitude and 500 m above sea level). This zone is in the extreme south of (NWFP) Pakistan at the bank of the River Indus. Dera Ismail Khan is bounded by Sulaiman Range to the West, the Indus River on the East, Marwat and Bhit- tani Ranges on the North and Vehowa Nala (Punjab) on the South. Besides certain local variability the area is comprised of four basic divisions viz mountains, a series …     

An integrated, multiparametric flow cytometry chip using ��microfluidic drifting�� based three-dimensional hydrodynamic focusing

In this work, we demonstrate an integrated, single-layer, miniature flow cytometry device that is capable of multi-parametric particle analysis. The device integrates both particle focusing and detection components on-chip, including a “microfluidic drifting” based three-dimensional (3D) hydrodynamic focusing component and a series of optical fibers integrated into the microfluidic architecture to facilitate on-chip detection. With this design, multiple optical signals (i.e., forward scatter, side scatter, and fluorescence) from individual particles can be simultaneously detected. Experimental results indicate that the performance of our flow cytometry chip is comparable to its bulky, expensive desktop counterpart. The integration of on-chip 3D particle focusing with on-chip multi-parametric optical detection in a single-layer, mass-producible microfluidic device presents a major step towards low-cost flow cytometry chips for point-of-care clinical diagnostics.     

An integrated, multiparametric flow cytometry chip using "microfluidic drifting" based three-dimensional hydrodynamic focusing

In this work, we demonstrate an integrated, single-layer, miniature flow cytometry device that is capable of multi-parametric particle analysis. The device integrates both particle focusing and detection components on-chip, including a "microfluidic drifting" based three-dimensional (3D) hydrodynamic focusing component and a series of optical fibers integrated into the microfluidic architecture to facilitate on-chip detection. With this design, multiple optical signals (i.e., forward scatter, side scatter, and fluorescence) from individual particles can be simultaneously detected. Experimental results indicate that the performance of our flow cytometry chip is comparable to its bulky, expensive desktop counterpart. The integration of on-chip 3D particle focusing with on-chip multi-parametric optical detection in a single-layer, mass-producible microfluidic device presents a major step towards low-cost flow cytometry chips for point-of-care clinical diagnostics.     

The English Translation of Arabic Puns in the Holy Quran

The pun is a tricky use of a word or phrase which has very different meanings that are closely interrelated, or of words with the same sound but different meanings. The Pun is a term with a dual meaning: “close” using obvious reference, and “far” using obscure reference. The hidden is usually meant. The close meaning is the sooner that comes to the listener’s mind. However, the speaker targets at the far one yet use the close to hide it. Translating the Quran text always raises several serious challenges in translation; these challenges are due to the different translations of puns and the misinterpretations between the intended meanings of a pun with their basic concepts, which could result in a certain amount of ambiguity. The study examines the Quranic corpus and its three versions of English translations. The study utilizes the typology of Delabastita?s for horizontal puns, Nida’s techniques of dynamic and formal equivalent and Newmark’s translation methods. This research attempts to investigate the semantic meaning of puns in the Quran translation and to define the translation techniques applied in translating the Quranic puns from Arabic into English.     

Peranan bahasa dalam kebudayaan

Bahawa “bahasa” dalam pengertian orang-orang Melayu tidaklah semata-mata bersifat lingual (yang hanya menjadi alat komunikasi antara dua pihak pengguna bahasa sahaja); tetapi bahasa itu adalah lebih kultural (yang menjadi pengilham dan pendorong manusia ke tahap lebih baik dalam hidupnya; sekaligus mempertinggi kebudayaan manusia itu).