Allograftic bone marrow-derived mesenchymal stem cells transplanted into heart infarcted model of rabbit to renovate infarcted heart

Objective: To investigate the directed transplantation of allograftic bone marrow-derived mesenchymal stem cells (MSCs) in myocardial infarcted (MI) model rabbits. Materials and Methods: Rabbits were divided into 3 groups, heart infarcted model with MSCs transplanted treatment (MSCs group, n=12), heart infarcted model with PBS injection (control group, n=20), sham operation with PBS injection (sham group, n=l 7). MSCs labelled by BrdUrd were injected into the MI area of the MSCs group. The same volume of PBS was injected into the MI area of the control group and sham group. The mortality, LVIDd, LVIDs and LVEF Of the two groups were compared 4 weeks later. Tropomyosin inhibitory component (Tn I) and BrdUrd immunohistochemistry identified the engrafted cells 4 weeks after transplantation. Result: The mortality of the MSCs group was 16.7% (2/12), and remarkably lower than the control group's mortality [35% (7/20) (P＜0.05)].Among the animals that survived for 4 weeks, the LVIDd and LVIDs of the MSCs group after operation were 1.17±0.21 cm and 0.74±0.13 cm, and remarkably lower than those of the model group, which were 1.64±0.14 cm and 1.19±0.12 cm (P＜0.05); the LVEF of the MSCs group after operation was 63±6%, and remarkably higher than that of the model group,which was 53±6% (P＜0.05). Among the 10 cases of animals that survived for 4 weeks in the MSCs group, in 8 cases (80%),the transplanted cells survived in the non MI, MI region and its periphery, and even farther away; part of them differentiated into cardiomyocytes; in 7 cases (70%), the transplanted cells participated in the formation of blood vessel tissue in the MI region. Conclusion: Transplanted allograftic MSCs can survive and differentiate into cardiomyocytes, form the blood vessels in the MI region. MSCs transplantation could improve the heart function after MI.     

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社会保障制度是社会的安全网和稳定器,也是构建社会主义和谐社会的重要组成部分.由于我国长期受城乡分割的二元社会保障制度的影响,目前农民养老保障仍然主要依靠传统的家庭养老和土地保障形式.在人口老龄化与工业化、城镇化迅猛发展的今天,传统的保障形式正在遭遇前所未有的挑战.如何应对农民养老风险,解决农民老有所养的问题,是摆在我们面前一个严峻而紧迫的问题.也是二十一世纪我国落实科学发展观,构建社会主义和谐社会必须直面的问题.     

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江泽民同志“三个代表”的重要思想，从根本上回答了新时期我们应当建设一个什么样的政党和怎样建设党的重大历史课题，形成了中国共产党在新时期建党学说新的理论基础，丰富和发展了中国共产党的建党学说和马列主义的建党理论。“三个代表”是中国共产党立党的三个坚实基础，即物质基础、精神基础、群众基础。     

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