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M. Skolimowski M. Weiss Nielsen F. Abeille P. Skafte-Pedersen D. Sabourin A. Fercher D. Papkovsky S. Molin R. Taboryski C. Sternberg M. Dufva O. Geschke J. Emnéus 《Biomicrofluidics》2012,6(3)
A modular microfluidic airways model system that can simulate the changes in oxygen tension in different compartments of the cystic fibrosis (CF) airways was designed, developed, and tested. The fully reconfigurable system composed of modules with different functionalities: multichannel peristaltic pumps, bubble traps, gas exchange chip, and cell culture chambers. We have successfully applied this system for studying the antibiotic therapy of Pseudomonas aeruginosa, the bacteria mainly responsible for morbidity and mortality in cystic fibrosis, in different oxygen environments. Furthermore, we have mimicked the bacterial reinoculation of the aerobic compartments (lower respiratory tract) from the anaerobic compartments (cystic fibrosis sinuses) following an antibiotic treatment. This effect is hypothesised as the one on the main reasons for recurrent lung infections in cystic fibrosis patients. 相似文献
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Many obstacles are involved in teaching statistics to undergraduates, including high attrition rates, students' anxiety, and a limited ability to grasp difficult concepts. These concerns can be addressed effectively by implementing strategies that require students to be actively engaged in the learning of statistics. First, we discuss how activity-based strategies and information technology can be an effective way to teach a statistics course. Second, we discuss how we changed a statistics course to include activity-based strategies. Finally, we discuss how cooperative learning, as a type of activity-based strategy, can increase students' understanding of statistics. 相似文献
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The purpose of this study was to investigate the effects of strategy instruction on the reading literacy of students with mild and moderate intellectual disability. Students aged 15–21 with intellectual disability (n=35) participated in 24 sessions of literacy strategy instruction (experimental condition) or remedial literacy‐skill acquisition‐ lessons (control condition). The main objective of strategy instruction was to foster comprehension monitoring. Through shared dialogues, students were trained to generate questions about text, to summarise what was read, to clarify difficult words and to make predictions. The strategies were taught using the reciprocal teaching method developed by Palincsar and Brown. This method involves provision of support adjusted to students’ difficulties and peer teaching of strategies. Control subjects were exposed to direct instruction of basic reading skills that were presented sequentially and practiced solitarily by the students. Opportunities were given to respond to questions and to summarise but no strategy instruction was provided to foster comprehension monitoring. Two different measures of comprehension and a measure of strategy use were administered to test for variation across different methods of instruction. Findings on all measures provide support for the claim that strategy instruction is indeed superior to traditional remedial methods of skill acquisition in fostering reading literacy comprehension. These findings challenge the common perception that literacy is an organic impossibility for people defined as intellectually disabled. Moreover, the results add to recent research in sociocognitive instruction that supports the need to modify prevailing methods of reading curriculum and suggests a reconceptualisation of the comprehension process and its instruction to students with intellectual disabilities. 相似文献
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Recent investigations designed to elucidate the teacher behaviors which are facilitative of positive student attitudes and increased student performance have presented inconsistent results. It is hypothesized that the inconsistency between studies may be due to an interaction between teacher characteristics and student characteristics in the determination of the dependent variables involved. To test this hypothesis, teachers and students in a West Coast high school were administered a revised version of the California F-Scale (a measure of authoritarianism). High- and Low-F groups of both teachers and students were selected, and students’ grades and attitudes toward their teachers were observed. It was found that High-F students exposed to Low-F teachers showed particularly low attitudes toward their teachers and particularly low grades. Data for other combinations of student and teacher characteristics were essentially equivalent. 相似文献
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Howard S. Bloom Stephen W. Raudenbush Michael J. Weiss Kristin Porter 《Journal of research on educational effectiveness》2017,10(4):817-842
The present article considers a fundamental question in evaluation research: “By how much do program effects vary across sites?” The article first presents a theoretical model of cross-site impact variation and a related estimation model with a random treatment coefficient and fixed site-specific intercepts. This approach eliminates several biases that can arise from unbalanced sample designs for multisite randomized trials. The article then describes how the approach operates, explores its assumptions, and applies the approach to data from three large welfare-to-work trials. The article also illustrates how to report cross-site impact findings and presents diagnostics for assessing these findings. To keep the article manageable, it focuses on experimental estimates of effects of program assignment (effects of intent to treat), although the ideas presented can be extended to analyses of multisite quasi-experiments and experimental estimates of effects of program participation (complier average causal effects). 相似文献
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Weiss SM 《Research quarterly for exercise and sport》2011,82(1):28-36
The effects of switching focusing strategies on complex motor skill learning were investigated using a dart-throwing task. Participants were screened for reinvestment of conscious processing by completing the Reinvestment Scale (RS) of Masters, Polman, and Hammond (1993). After an initial baseline phase, two focusing strategies were described. Low and high reinvestors were then asked which of the strategies was used during baseline. Regardless of preference, they were requested to change focus. Novice dart-players used either a nonpreferred internal focus (EI), in which they were asked to concentrate on movements of their body, or a nonpreferred external focus (JE), in which they were asked to focus on the effects of their movements. This procedure produced two separate groups, El and 1E. Those scoring low and high on the RS were separated, thus producingfourgroups. Participants in the El high group were the least successful. These results support the findings of earlier studies suggesting that switching to an El is detrimental. Additionally, it appears that high reinvestors switching from a preferred 1E to a nonpreferred El are the most susceptible to unsuccessful performance. 相似文献