Polymorphisms within the COL5A1 gene and regulators of the extracellular matrix modify the risk of Achilles tendon pathology in a British case-control study

Several genetic loci have been associated with risk of Achilles tendon pathology (ATP) within South African and Australian populations. The aim of this study was, therefore, to evaluate eight previously implicated genetic variants in an independent British population. A total of 130 asymptomatic controls (CON) and 112 participants clinically diagnosed with ATP comprising 87 individuals with chronic Achilles tendinopathy (TEN) and 25 with Achilles tendon ruptures (RUP) were included. All participants were genotyped for variants within the COL5A1, MIR608, IL-1β, IL-6 and CASP8 genes. Primary findings implicated COL5A1 and CASP8. Three inferred allele combinations constructed from COL5A1 rs12722, rs3196378 and rs71746744 were identified as risk modifiers. The T–C–D combination was associated with increased risk of ATP (P = 0.023) and RUP (P < 0.001), the C–A–I combination was associated with increased risk of ATP (P = 0.011), TEN (P = 0.011) and RUP (P = 0.011) and the C–C–D combination was associated with decreased risk of ATP (P = 0.011) and RUP (P = 0.004). The CASP8 rs3834129 DD genotype was associated with decreased risk of TEN (P = 0.020, odds ratio: 0.45, 95% confidence interval: 0.22–0.90) and the CASP8 I–G (rs3834129–rs1045485) inferred allele combination was associated with increased risk of TEN (P = 0.031). This study further highlights the importance of polymorphisms within COL5A1 and CASP8 in the aetiology of ATP.     

Can a Multiple-Choice Exam Discriminate Between Masters and Nonniasters of Instructional Design?

This study was conducted to determine if a norm-referenced test designed to assess instructional design competency could be statistically validated (i.e., confirmed statistically to discriminate between known masters and known nonmasters of instructional design). The test was composed of items written to assess verified competencies required of instructional design professionals. A total of 257 respondents participated in the study over the course of three stages: initial item bank construction, item analysis to determine those items with discrimination power, and the concurrent validity calculation, including determination of the mastery cut-off score. Mean scores of five groups of respondents were analyzed in the final stage. Statistically significant differences were found among the Professional Masters, Education Graduate Students and Undergraduates, Noneducation Graduate Students, and Noneducation Undergraduates. The article concludes with a discussion of the role of such an instrument in conducting research in the field.     

A Comprehensive Model for the Transfer of Training

The transfer of newly learned skills from a training situation to actual on-the-job performance is one of the most important aspects of training design and development, since this process is the ultimate goal of nearly any training session. Based on an extensive literature review in a variety of educational and corporate content areas, the following article presents a model for the effective transfer of newly learned skills from the training classroom to worksite implementation. The model includes three overall stages (pre-training, training, and post-training) and specific strategies in each stage for use by trainers, managers, and other corporate professionals. While useful in a variety of settings, this model should prove particularly helpful to instructional designers and corporate trainers involved in developing instruction to improve the performance of employees at all levels.