Investigation of Poor Academic Achievement in Children with Duchenne Muscular Dystrophy

Duchenne Muscular Dystrophy (DMD) is a neurogenetic developmental disorder that presents with progressive muscular weakness. It is caused by a mutation in a gene that results in the absence of specific products that normally localize to muscle cells and the central nervous system (CNS). The majority of affected individuals have IQs within the normal range, generally with lower verbal than performance IQ scores. Prior work has demonstrated selective deficits on tests of verbal span and immediate memory. For the current study, 26 boys with DMD (and normal intellectual function) and their unaffected siblings were evaluated. Paired comparisons demonstrated that the children with DMD had significantly poorer academic achievement scores than their siblings, even though their vocabulary levels and home and educational environments were comparable. Children with DMD also had more behavioral concerns, physical disabilities, and poorer verbal memory spans. Linear regression indicated that behavioral concerns, executive function, and physical disability did not contribute substantially to academic performance, whereas performance on verbal span did. DMD presents with a selective developmental aberration in verbal span that has wide‐ranging consequences on learning skills.     

The use of personal digital assistants in the health sciences: results of a survey.

OBJECTIVES: The purpose of this study is to determine how personal digital assistants (PDAs) are used on an academic health sciences campus to define the level of training and support the library can provide to the students and faculty. METHOD: A Web-based questionnaire was developed. A total of 1,538 health sciences faculty and residents were sent an email message requesting participation. Data from the returned surveys were analyzed with SPSS. RESULTS: Sixty-one percent of survey respondents used PDAs. The address book, date book, and calculator were the most common uses reported for PDAs. Residents also reported a high use of drug databases on their PDAs. Most survey respondents indicated they would like to learn more about clinical resources for PDAs. CONCLUSIONS: Many opportunities exist for librarians to provide training and support for PDAs, in addition to evaluation and promotion of clinical software for PDAs.     

Online journals' impact on the citation patterns of medical faculty.

PURPOSE: The purpose was to determine the impact of online journals on the citation patterns of medical faculty. This study looked at whether researchers were more likely to limit the resources they consulted and cited to those journals available online rather than those only in print. SETTING: Faculty publications from the college of medicine at a large urban university were examined for this study. The faculty publications from a regional medical college of the same university were also examined in the study. The number of online journals available for faculty, staff, and students at this institution has increased from an initial core of 15 online journals in 1998 to over 11,000 online journals in 2004. METHODOLOGY: Searches by author affiliation were performed in the Web of Science to find all articles written by faculty members in the college of medicine at the selected institution. Searches were conducted for the following years: 1993, 1996, 1999, and 2002. Cited references from each faculty-authored article were recorded, and the corresponding cited journals were coded into four categories based on their availability at the institution in this study: print only, print and online, online only, and not owned. Results were analyzed using SPSS. RESULTS: The number of journals cited per year continued to increase from 1993 to 2002. The results did not indicate that researchers were more likely to cite online journals or were less likely to cite journals only in print. At the regional location where the number of print-only journals was minimal, use of the print-only journals did decrease in 2002, although not significantly. CONCLUSION/DISCUSSION: It is possible that electronic access to information (i.e., online databases) has had a positive impact on the number of articles faculty will cite. Results of this study suggest, at this point, that faculty are still accessing the print-only collection, at least for research purposes, and are therefore not sacrificing quality for convenience.     

The impact of microfluidics in high-throughput drug-screening applications

Drug discovery is an expensive and lengthy process. Among the different phases, drug discovery and preclinical trials play an important role as only 5–10 of all drugs that begin preclinical tests proceed to clinical trials. Indeed, current high-throughput screening technologies are very expensive, as they are unable to dispense small liquid volumes in an accurate and quick way. Moreover, despite being simple and fast, drug screening assays are usually performed under static conditions, thus failing to recapitulate tissue-specific architecture and biomechanical cues present in vivo even in the case of 3D models. On the contrary, microfluidics might offer a more rapid and cost-effective alternative. Although considered incompatible with high-throughput systems for years, technological advancements have demonstrated how this gap is rapidly reducing. In this Review, we want to further outline the role of microfluidics in high-throughput drug screening applications by looking at the multiple strategies for cell seeding, compartmentalization, continuous flow, stimuli administration (e.g., drug gradients or shear stresses), and single-cell analyses.     

亲水性废旧轮胎橡胶粉的制备及在固井水泥中的应用

针对废旧轮胎橡胶粉作为油气井固井水泥增韧剂使用时,因胶粉表面强疏水性导致分散性不良而影响实际使用效果的技术问题,研究生产了一种表面亲水性良好的改性废旧轮胎橡胶粉,并初步探索了其作为固井水泥增韧剂的使用效果。实验结果表明：所制备的改性橡胶粉在水性体系中分散性良好,分散稳定时间大于48h;作为固井水泥增韧剂使用时,可明显改善水泥石的抗冲击性能（改性胶粉添加量3%时,水泥石的抗冲击性能可提高14.3%）,显示出良好的增韧效果。     

The energetics and benefit of an arm swing in submaximal and maximal vertical jump performance

The aims of this study were to investigate the energy build-up and dissipation mechanisms associated with using an arm swing in submaximal and maximal vertical jumping and to establish the energy benefit of this arm swing. Twenty adult males were asked to perform a series of submaximal and maximal vertical jumps while using an arm swing. Force, motion and electromyographic data were recorded during each performance and used to compute a range of kinematic and kinetic variables, including ankle, knee, hip, shoulder and elbow joint powers and work done. It was found that the energy benefit of using an arm swing appears to be closely related to the maximum kinetic energy of the arms during their downswing, and increases as jump height increases. As jump height increases, energy in the arms is built up by a greater range of motion at the shoulder and greater effort of the shoulder and elbow muscles but, as jump height approaches maximum, these sources are supplemented by energy supplied by the trunk due to its earlier extension in the movement. The kinetic energy developed by the arms is used to increase their potential energy at take-off but also to store and return energy from the lower limbs and to "pull" on the rest of the body. These latter two mechanisms become more important as jump height increases with the pull being the more important of the two. We conclude that an arm swing contributes to jump performance in submaximal as well as maximal jumping but the energy generation and dissipation sources change as performance approaches maximum.     

The educational approach within Colombia's nutrition plan (PAN)

With the knowledge that malnutrition affects the quality of life of an individual, the Colombian Government set up in 1976 a unique multi-sectorial plan (PAN), to combat the country's serious malnutrition. Government agencies and private industries in the sectors of production, distribution, health, sanitation, and education have coordinated their previously independent efforts. Among the interesting aspects are the coordination of sectors through work at various levels and through control of the budget, the limitation of bureaucracy, and the decentralization of decision-making. The ongoing attempts to overcome the difficulties encountered include making decisions in the face of inconclusive knowledge on what constitutes a well-balanced diet; combating the lack of knowledge of professionals about the environment of the poorest percentage of the population; and revising the traditional teaching method to make it more successful through a multi-media approach to assure wider coverage and more impact for the least cost, using materials such as games, puppets, posters and radio.

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Zusammenfassung In der Erkenntnis, dass Untererernährung die Lebensqualität des Menschen beeinträchtigt, erstellte die kolumbianische Regierung im Jahre 1976 einen einzigartigen, mehrere Sektoren umfassenden Plan (Pan), um die schwerwiegende Unterernährung im Lande zu bekämpfen. Gemäss diesem Plan werden jetzt die früher zerstreuten Bemühungen von Behörden und privaten Industrieunternehmen auf den Sektoren Produktion, Verteilung, Gesundheit, Kanalisation und Erziehung koordiniert. Zu den interessantesten Aspekten gehören die Koordinierung von Sektoren durch Arbeit auf verschiedenen Ebenen sowie durch Kontrolle der Etats, die Beschränkung der Bürokratie und die Dezentralisierung von Entscheidungsbefugnissen. Unter den Versuchen, die bestehenden Schwierigkeiten zu überwinden, werden hervorgehoben: Entscheidungen angesichts unzureichenden Verständnisses von ausgewogener Ernährung; Bekämpfung des Mangels an Kenntnissen von Umweltspezialisten über den ärmsten Teil der Bevölkerung; und Revision der traditionellen Lehrmethoden mit dem Ziel, sie durch Einführung eines Multi-Medienansatzes, d.h. durch den Gebrauch von Spielen, Marionetten, Plakaten und Radio erfolgreicher zu gestalten.

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Résumé Conscient du fait que la sous-alimentation affecte la qualité de vie d'un individu, le Gouvernement colombien a appliqué en 1976 un plan unique à secteurs multiples (PAN) dont le but est de combattre la sérieuse sousalimentation du pays. Les agences gouvernementales et les industries privées appartenant aux secteurs de la production, de la distribution, de la santé, de l'hygiène et de l'éducation coordonnent désormais leurs efforts précédemment dispersés. Parmi les aspects intéressants de ce plan, on relève la coordination des secteurs tant au moyen du travail à différents niveaux que du contrôle du budget, la limitation de la bureaucratie et la décentralisation de la prise de décision. Les efforts qui se poursuivent dans l'intention de venir à bout des difficultés rencontrées visent à prendre des décisions malgré les connaissances nonconcluantes de ce qui constitue un régime bien équilibré; à combattre le manque de connaissance des professionnels sur l'environnement du pourcentage le plus pauvre de la population; à réviser la méthode d'enseignement traditionnel en utilisant des moyens d'approche par multimedia, ceci afin d'assurer une plus grande couverture de la population, avec un impact supérieur, et ce au moindre prix, en utilisant comme matériel des jeux, des marionnettes, des affiches illustrées ainsi que la radio.

     

Sur l'Acquisition des structures numériques en fin de 3ème

Sans résuméRésultats d'une enquête effectuée en mai-juin 1973 par une équipe de l'IREM de Strasbourg dans les classes de 3ème du Bas-Rhin.L'équipe comprenait quatre membres de l'IREM:Mathématiciens:—Mademoiselle Anne Scherpereel—Monsieur François PluvinagePsychologues:—Mademoiselle Catherine Bloch—Monsieur Raymond Duval.